Estimation SOC for Li-Ion Batteries in EVs Using EKF

Recently, secondary batteries have attracted a lot of attention. They have been used as an energy source in electric vehicles (EVs), hybrid electric vehicles (HEVs) and smart grids. This attention increases by emerging more demand for decreasing CO2 gas in the air and having more renewable source. For those applications for rechargeable batteries and specifically Li-ion chemistry based ones, the battery management system (BMS) needs to have a very close to the truth guess of state of charge (SOC) of each individual cell in the battery pack. This research paper presents an extended Kalman filter based method to estimate SOC of Li-ion batteries. The validity of the procedure is demonstrated experimentally for an APR18650m1 LiFePO4 battery

Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials

SummaryPlasmodium falciparum pathogenesis is affected by various cell types in the blood, including platelets, which can kill intraerythrocytic malaria parasites. Platelets could mediate these antimalarial effects through human defense peptides (HDPs), which exert antimicrobial effects by permeabilizing membranes. Therefore, we screened a panel of HDPs and determined that human platelet factor 4 (hPF4) kills malaria parasites inside erythrocytes by selectively lysing the parasite digestive vacuole (DV). PF4 rapidly accumulates only within infected erythrocytes and is required for parasite killing in infected erythrocyte-platelet cocultures. To exploit this antimalarial mechanism, we tested a library of small, nonpeptidic mimics of HDPs (smHDPs) and identified compounds that kill P. falciparum by rapidly lysing the parasite DV while sparing the erythrocyte plasma membrane. Lead smHDPs also reduced parasitemia in a murine malaria model. Thus, identifying host molecules that control parasite growth can further the development of related molecules with therapeutic potential

De novo design of self-assembling foldamers that inhibit heparin-protein interactions

A series of self-associating foldamers have been designed as heparin reversal agents, as antidotes to prevent bleeding due to this potent antithrombotic agent. The foldamers have a repeating sequence of Lys-Sal, in which Sal is 5-amino-2-methoxy-benzoic a