Emotional and behavioral reaction to intrusive thoughts.

A self-report measure of the emotional and behavioral reactions to intrusive thoughts was developed. The article presents data that confirm the stability, reliability, and validity of the new seven-item measure. Emotional and behavioral reactions to intrusions emerged as separate factors on the Emotional and Behavioral Reactions to Intrusions Questionnaire (EBRIQ), a finding confirmed by an independent stress study. Test-retest reliability over 30 to 70 days was good. Expected relationships with other constructs were significant. Stronger negative responses to intrusions were associated with lower mindfulness scores and higher ratings of experiential avoidance, thought suppression, and intensity and frequency of craving. The EBRIQ will help explore differences in reactions to intrusive thoughts in clinical and nonclinical populations, and across different emotional and behavioral states. It will also be useful in assessing the effects of therapeutic approaches such as mindfulness

XMM-Newton observation of the interacting galaxies NGC1512 and NGC1510

The galaxy NGC1512 is interacting with the smaller galaxy NGC1510 and shows a peculiar morphology, characterised by two extended arms immersed in an HI disc whose size is about four times larger than the optical diameter of NGC1512. For the first time we performed a deep X-ray observation of the galaxies NGC1512 and NGC1510 with XMM-Newton to gain information on the population of X-ray sources and diffuse emission in a system of interacting galaxies. We identified and classified the sources detected in the XMM-Newton field of view by means of spectral analysis, hardness-ratios calculated with a Bayesian method, X-ray variability, and cross-correlations with catalogues in optical, infrared, and radio wavelengths. We also made use of archival Swift (X-ray) and Australia Telescope Compact Array (radio) data to better constrain the nature of the sources detected with XMM-Newton. We detected 106 sources in the energy range of 0.2-12 keV, out of which 15 are located within the D_25 regions of NGC1512 and NGC1510 and at least six sources coincide with the extended arms. We identified and classified six background objects and six foreground stars. We discussed the nature of a source within the D_25 ellipse of NGC1512, whose properties indicate a quasi-stellar object or an intermediate ultra-luminous X-ray source. Taking into account the contribution of low-mass X-ray binaries and active galactic nuclei, the number of high-mass X-ray binaries detected within the D_25 region of NGC1512 is consistent with the star formation rate obtained in previous works based on radio, infrared optical, and UV wavelengths. We detected diffuse X-ray emission from the interior region of NGC1512 with a plasma temperature of kT=0.68(0.31-0.87) keV and a 0.3-10 keV X-ray luminosity of 1.3E38 erg/s, after correcting for unresolved discrete sources.Comment: Accepted for publication in Astronomy and Astrophysics. 20 pages. Appendix B will be published electronically onl

Voluntary activation of muscle in humans: Does serotonergic neuromodulation matter?

Ionotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the motoneurone, whereas neuromodulatory inputs control the state of excitability of the motoneurone. Intracellular recordings of motoneurones from in vitro and in situ animal preparations have provided extraordinary insight into the mechanisms that underpin how neuromodulators regulate neuronal excitability. However, far fewer studies have attempted to translate the findings from cellular and molecular studies into a human model. In this review, we focus on the role that serotonin (5-HT) plays in muscle activation in humans. 5-HT is a potent regulator of neuronal firing rates, which can influence the force that can be generated by muscles during voluntary contractions. We firstly outline structural and functional characteristics of the serotonergic system, and then describe how motoneurone discharge can be facilitated and suppressed depending on the 5-HT receptor subtype that is activated. We then provide a narrative on how 5-HT effects can influence voluntary activation during muscle contractions in humans, and detail how 5-HT may be a mediator of exercise-induced fatigue that arises from the central nervous system. (Figure presented.)

Alcohol consumption in young adults: the role of multisensory imagery.

Accepted 19.11.2013Little is known about the subjective experience of alcohol desire and craving in young people. Descriptions of alcohol urges continue to be extensively used in the everyday lexicon of young, non-dependent drinkers. Elaborated Intrusion (EI) Theory contends that imagery is central to craving and desires, and predicts that alcohol-related imagery will be associated with greater frequency and amount of drinking. This study involved 1,535 age stratified 18- 25 year olds who completed an alcohol–related survey that included the Imagery scale of the Alcohol Craving Experience (ACE) questionnaire. Imagery items predicted 12-16% of the variance in concurrent alcohol consumption. Higher total Imagery subscale scores were linearly associated with greater drinking frequency and lower self-efficacy for moderate drinking. Interference with alcohol imagery may have promise as a preventive or early intervention target in young people

XMM-Newton observation of SNR J0533-7202 in the Large Magellanic Cloud

Aims. We present an X-ray study of the supernova remnant SNR J0533-7202 in the Large Magellanic Cloud (LMC) and determine its physical characteristics based on its X-ray emission. Methods. We observed SNR J0533-7202 with XMM-Newton (flare-filtered exposure times of 18 ks EPIC-pn and 31 ks EPIC-MOS1/MOS2). We produced X-ray images of the SNR, performed an X-ray spectral analysis, and compared the results to multi-wavelength studies. Results. The distribution of X-ray emission is highly non-uniform, with the south-west region brighter than the north-east. The X-ray emission is correlated with the radio emission from the remnant. We determine that this morphology is likely due to the SNR expanding into a non-uniform ambient medium and not an absorption effect. We estimate the size to be 53.9 (\pm 3.4) x 43.6 (\pm 3.4) pc, with the major axis rotated ~64 degrees east of north. We find no spectral signatures of ejecta and infer that the X-ray plasma is dominated by swept-up interstellar medium. Using the spectral fit results and the Sedov self-similar solution, we estimate an age of ~17-27 kyr, with an initial explosion energy of (0.09-0.83) x 10^51 erg. We detected an X-ray source located near the centre of the remnant, namely XMMU J053348.2-720233. The source type could not be conclusively determined due to the lack of a multi-wavelength counterpart and low X-ray counts. We find that it is likely either a background active galactic nucleus or a low-mass X-ray binary in the LMC. Conclusions. We detected bright thermal X-ray emission from SNR J0533-7202 and determined that the remnant is in the Sedov phase of its evolution. The lack of ejecta emission prohibits us from typing the remnant with the X-ray data. Therefore, the likely Type Ia classification based on the local stellar population and star formation history reported in the literature cannot be improved upon.Comment: 7 pages, 4 figures, accepted for publication in Astronomy and Astrophysic

XMM-Newton study of 30 Dor C and a newly identified MCSNR J0536-6913 in the Large Magellanic Cloud

Aims: We present a study of the superbubble (SB) 30 Dor C and the newly identified MCSNR J0536-6913 in the LMC. Methods: All available XMM-Newton data (exposure times of 420 ks EPIC-pn, 556 ks EPIC-MOS1, 614 ks EPIC-MOS2) were used to characterise the thermal X-ray emission in the region. An analysis of the non-thermal X-rays is also presented and discussed in the context of emission mechanisms previously suggested in the literature. These data are supplemented by X-ray data from Chandra, optical data from the MCELS, and radio data from ATCA and MOST. Results: The brightest thermal emission was found to be associated with a new supernova remnant, MCSNR J0536-6913. X-ray spectral analysis of MCSNR J0536-6913 suggested an ejecta-dominated remnant with lines of O, Ne, Mg, and Si, and a total 0.3-10 keV luminosity of ~8E+34 erg/s. Based on derived ejecta abundance ratios, we determined the mass of the stellar progenitor to be either ~18 M_sun or as high as >40 M_sun, though the spectral fits were subject to assumptions (e.g., uniform temperature and well-mixed ejecta). The thermal emission from the SB exhibited enrichment by alpha-process elements, evidence for a recent core-collapse SNR interaction with the SB shell. We detected non-thermal X-ray emission throughout 30 Dor C, with the brightest regions being highly correlated with the H-alpha and radio shells. We created a non-thermal spectral energy distribution for the north-eastern shell of 30 Dor C which was best-fit with an exponentially cut-off synchrotron model. Conclusions: Thermal X-ray emission from 30 Dor C is very complex, consisting of a large scale SB emission at the eastern shell wall with the brightest emission due to MCSNR J0536-6913. The fact that the non-thermal spectral energy distribution of the SB shell was observed to roll-off is further evidence that the non-thermal X-rays from 30 Dor C are synchrotron in origin.Comment: 22 pages, 21 figures, accepted for publication in Astronomy and Astrophysic

5-HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons

The intrinsic electrical properties of motoneurons strongly affect motoneuron excitability to fast-acting excitatory ionotropic inputs. Serotonin (5-HT) is a neurochemical that alters the intrinsic properties of motoneurons, whereby animal models and in vitro experiments indicate that 5-HT increases motoneuron excitability by activating 5-HT2 receptors on the somato-dendritic compartment. In the current study, we examined how antagonism of the 5-HT2 receptor affects motoneuron excitability in humans. We hypothesised that motoneuron excitability would be reduced. The 5-HT2 antagonist cyproheptadine was administered to 10 healthy participants in a double-blinded, placebo-controlled, crossover trial. Electrical cervicomedullary stimulation was used to deliver a synchronised excitatory volley to motoneurons to elicit cervicomedullary motor evoked potentials (CMEPs) in the surface electromyography (EMG) signal of the resting biceps brachii. Likewise, electrical peripheral nerve stimulation was used to generate antidromic spikes in motoneurons and cause recurrent discharges, which were recorded with surface EMG as F-waves in a resting hand muscle. Compared with placebo, we found that 5-HT2 antagonism reduced the amplitude and persistence of F-waves but did not affect CMEP amplitude. 5-HT2 antagonism also reduced maximal contraction strength. The reduced recurrent discharge of motoneurons with 5-HT2 antagonism suggests that 5-HT2 receptors modulate the electrical properties of the initial segment or soma to promote excitability. Conversely, as cyproheptadine did not affect motoneuron excitability to brief synaptic input, but affected maximal contractions requiring sustained input, it seems likely that the 5-HT2-mediated amplification of synaptic input at motoneuron dendrites is functionally significant only when excitatory input activates persistent inward currents

People trying to lose weight dislike calorie counting apps and want motivational support to help them achieve their goals.

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Abortion provision in Northern Ireland: the views of health professionals working in obstetrics and gynaecology units

Introduction: Abortion became decriminalised in Northern Ireland in October 2019. Until that point there existed no evidence concerning the views of health professionals on decriminalisation or on their willingness to be involved in abortion care. The purpose of this study was to address this lack of evidence, including all categories of health professionals working in obstetrics and gynaecology units in Northern Ireland. Methods: The online survey was targeted at medical, nursing and midwifery staff working in the obstetrics and gynaecology units in each Health and Social Care (HSC) Trust in Northern Ireland. The survey was issued via clinical directors in each Trust using the REDCap platform. Results: The findings showed widespread support for decriminalisation of abortion up until 24 weeks’ gestation (n=169, 54%). The majority of clinicians stated they were willing to provide abortions in certain circumstances (which were undefined) (n=188, 60% medical abortions; n=157, 50% surgical abortions). Despite regional variation, the results show that there are sufficient numbers of clinicians to provide a service within each HSC Trust. The results indicate that many clinicians who report a religious affiliation are also supportive of decriminalisation (n=46, 51% Catholic; n=53, 45% Protestant) and are willing to provide care, countering the assumption that those of faith would all raise conscientious objections to service provision. Conclusions: The findings of this study are very encouraging for the development, implementation and delivery of local abortion care within HSC Trusts in Northern Ireland and should be of value in informing commissioners and providers about the design of a service model and its underpinning training programmes

Unsung heroes: Constituency election agents in British general elections

Despite their central role in the electoral process, constituency agents have been largely overlooked by political scientists and this article seeks to rectify the omission. It sketches the origins and development of the role of agent from the late 19th century and suggests that a serious rethink of the role took place in the 1990s. Survey-based evidence about the social characteristics of agents is presented confirming that they are largely middle-aged, middle-class, well-educated men. They are also becoming more experienced, offer realistic assessments of the impact of constituency campaigning and, arguably, many take a long-term view of how their party's support can be maximised