PUSHPAGHNI JATAHARINI IN MODERN SCIENTIFIC PERSPECTIVE: A REVIEW

Jataharini has described by Acharya Kashyapa in Revati Kalpaadhyaya of Kalpasthana in Kashyapa Samhita. Jataharini is a group of disease that affects the women during their different stages of life. It not only affects the women but also their foetuses, neonates and children. Pushpaghni Jataharini is one of them which affect the women at their reproductive age. Adharma (unrighteousness) is a most important cause for affliction by Jataharini as described by Acharya Kashyapa. Adharma may be said to some extent as lifestyle changes in present time. This lifestyle changes due to modernization has given rise to many lifestyle disorders like diabetes, cardiovascular diseases and polycystic ovarian disease etc. PCOS is one of the most common lifestyle disorders occurring in females. PCOS is emerging as a burning disease affecting a growing number of urban Indian women. A recent rise in PCOS cases in urban India may be due to modernization, stress and lifestyle changes. By analyzing the symptoms of both Pushpaghini Jataharini and PCOS, it is found that both are similar to some extent. In ancient time, Acharya Kashyapa has considered spiritual power responsible for disease. The causation of disease is not defined on scientific role of Doshas. An effort is made in this article to give some scientific reasons why Pushpaghini Jataharini is close to the Polycystic Ovarian Syndrome. As India has been labelled as the ‘diabetic capital of the world’ due to an alarming increase in the number of cases of both diabetes and metabolic syndrome, it is possible that there may be an increasing number of cases of PCOS as well as because PCOS is also a disorder of insulin metabolism. Thus PCOS is a syndrome showing an alarming rise in India and adding economic health burden of the country

Role of hysteroscopy in management of abnormal uterine bleeding in perimenopausal women

Background: In perimenopausal women blind endometrial sampling, dilation and curettage (D and C) was the standard treatment. Since hysteroscopy offers complete visualization of entire endometrial cavity. This prospective study was undertaken to evaluate its role. As whole of endometrial cavity examined and target biopsy can be taken from suspected area so that no carcinoma is missed.  Thus, study was conducted to evaluate role of hysteroscopy in abnormal uterine bleeding (AUB) in women of perimenopausal age group and to correlate the hysteroscopic findings with that of histopathology and to see complication of hysteroscopy, if any.Methods: The study was carried out in the department of obstetrics and gynecology at Kasturba hospital, Delhi, India. 162 patients of age group 40-55 years with AUB were included. Any demonstrable pelvic pathology like cancer of cervix, vagina or endometrium and active pelvic inflammatory disease (PID) was set as exclusion criteria. All patients were subjected to hysteroscopy followed by D and C and findings of hysteroscopy and histopathology was correlated.Results: On hysteroscopy endometrium was normal in 49.3%, hyperplastic in 24.6%, atrophic in 10.4% and suspected carcinoma endometrium in 3.08%. Endometrial polyp and submucous fibroid was seen in 4.9% cases and 7.4% cases each. On confirmation by histopathology the findings were: normal endometrium in 55.4% cases, hyperplastic in 20.3%, atrophic in 9.9% and carcinoma endometrium in 1.85%. All cases of submucous fibroid and polyp were confirmed on histopathology.Conclusions: Hysteroscopy increases the accuracy of clinical diagnosis and may serve as an adjunct in the treatment of patients with specific intrauterine pathological conditions causing AUB

Electives in Medical Curriculum- An Insight of Medical Students

Background: Electives include courses that are interest based, where the students are free to choose the course content. NMC has introduced electives in medical curriculum and it has been implemented for the first time in various medical colleges. Aims and Objectives: The objective of this study is to assess the perception of MBBS students regarding Electives program. Methodology: This cross-sectional study was conducted among the first batch of MBBS students that completed the electives program after taking their consent and approval from ethical committee. Electives Experience scale (EES) and Electives Rating Scale (ERS) were developed, tested, and used for this study. Median, inter quartile range, Cronbach’s alpha and Mann Whitney tests were used for analysis. Results: Most of the students learnt theory, practical, AETCOM (ethics & communication), clinical skills and research in both blocks of posting but research was more focussed in block 1 and practical knowledge and clinical skills in block 2. For the Likert scales (EES-1, EES-2, ERS-1, ERS-2 & ERS), Cronbach’s alpha was found to be quite robust for all the scales. Median and inter quartile range were calculated for EES and ERS scores. Mann Whitney test showed significant gender difference for EES-2. If the student had got elective of his/her choice in block 1, the mean ranks of EES & ERS were significantly higher but if the student had got the elective of his/her choice in block 2, significantly higher scores were seen in overall ERS, ERS-2 and EES-2 only. Conclusion: Electives is a welcome addition to the medical curriculum. However, proactive approach from the student is a must to utilize this opportunity to the fullest

NEURAL NETWORK CORRELATION BASED SIMILARITY EVALUATION WITH ZERNIKE MOMENTS FOR THE POSE-INVARIANT FACE RECOGNITION

Human face recognition is best application in pattern recognition for identification and recognition. Development of face recognition system is increasing day by day in market and research organizations. Different parameters and methods are used for face recognition. In this research project, we will discuss about the different algorithms used for face recognition that are Zernike Moments (ZMs) and correlation classification (CC) etc and compare these algorithms with proposed algorithm Z_CC (Zernike with Correlation Classification).The angular information or rotation of the face is calculated by using the Zernike moments (ZM) to obtain the degree or radian of face rotation from the frontal view. The robust combination of angle-invariant and scale-invariant features with the combination of Zernike moments and correlation classification has been proposed with the neural network classification. The experiments will be performed on the variety of datasets. The multi-object dataset has been combined by collection the samples with faces rotated in the training samples. Z_NN (Zernike with neural network) algorithm provide best recognition rate for human face recognition 90%. In this algorithm we use Zernike Moments and correlation for global feature extraction and after that these features are compared by using neural network

Comparison of parenteral tramadol and epidural ropivacaine for labour analgesia: a prospective clinical study

Background: The pain of childbirth is one of the most severe types of pain that a woman experiences in her lifetime. Adequate analgesia during labour has a positive influence on the course of labour. For labor analgesia several non-pharmacologic and pharmacologic methods are adopted. The objective of the study is to compare parenteral tramadol and epidural ropivacaine with regard to maternal and labour outcome.Methods: This prospective, comparative, interventional clinical study was conducted at Kasturba Hospital, Daryaganj, Delhi, on the patients admitted in the labour room of the hospital during the period of September 2014 to July 2015. Various parameters of maternal condition and labour outcome in each group were monitored and compared. These included the degree of pain relief and patient satisfaction, duration of 1st and 2nd stage of labour, mode of delivery and duration of third stage and any third stage complication like post-partum haemorrhage (PPH) and retained placenta and side effect profile of both the drugs.Results: Epidural ropivacaine has significantly better analgesic efficacy and faster onset of action as compared to I/M tramadol and patients in epidural group were significantly better satisfied. Ninety-two percent of patients in tramadol group and eighty eight percent in epidural group underwent normal delivery. Duration of the three stages of labour, complications of third stage and side effect profile in both the groups were comparable.Conclusions: Maternal outcome in labour analgesia is similar with 100 mg I/M tramadol and epidural ropivacaine. There is no significant difference between duration of labour, rate of LSCS, incidence of instrumental delivery and neonatal outcome in the two modes of analgesia. Analgesic efficacy with epidural ropivacaine seems to be better compared to intramuscular tramadol. 

A study to compare the clinical outcome of sublingual and vaginal misoprostol in the medical management of missed miscarriage in first trimester

Background: Objective of the study was to compare the efficacy, outcome and side effects of sublingual and vaginal misoprostol for the medical management of missed miscarriage.Methods: Fifty women diagnosed as having missed miscarriage of gestational age less than 20 weeks were randomized to vaginal or sublingual route of drug administration by lottery method (random sampling) A total number of 25 cases in each of the two groups were considered. Women in Group A received 400 microgram of misoprostol sublingually every four hours for a maximum of 5 doses and those in Group B received 400 microgram of misoprostol vaginally every four hours for a maximum of 5 doses.  The primary outcome measures were, complete evacuation of products of conception, mean induction to delivery time and the occurrence of side effects.Results: In complete evacuation rates between the sublingual misoprostol and the vaginal misoprostol groups there was no statistically significant difference. Mean induction to delivery time was also similar for both groups as was the total number of doses required. As far as Side effects were concerned, Diarrhea was the major frequent side effect of sublingual misoprostol seen in 32% cases against only 12% cases with vaginal misoprostol.Conclusions: The effectiveness of Sublingual misoprostol is comparable to that of vaginal misoprostol for medical management of missed miscarriage but is associated with an increased risk of side effects especially diarrhoea

Clinical presentation and outcome of ectopic pregnancies in a tertiary care rural hospital

Background: Ectopic pregnancy is the commonest cause of the maternal morbidity and mortality in the first trimester of the pregnancy. The aim of this study was to see the clinical presentation, associated risk factors, mode of treatment and outcome.Methods: Retrospective study conducted in a tertiary care rural hospital. Women with diagnosis of ectopic pregnancy admitted between August 2016 to September 2018 were studied. Medical record files were scrutinized to get the details. Data was analyzed using Microsoft Office Excel (version 2007). Numerical data were subjected to descriptive analysis, with mean±standard deviation (SD) and categorical data as frequency and percentage.Results: Forty cases of ectopic pregnancy were included who were unbooked, non-smokers, married and belonged to rural areas. Eighty percent were in the age group of 20 to 30 years.  Maximum were gravida 3 or 4 with commonest presentation was pain, site was tubal. Laparotomy was done in 95% of women salpingectomy was the commonest surgical procedure done in 32 (80%) women. Salpingoophrectomy was done in one woman and lifesaving hysterectomy in 2 (5%) women for cervical and ruptured interstitial ectopic pregnancy one each. Blood transfusion was required in 28 (70%) women. No mortality was seen.Conclusions: Women of reproductive age group with pain abdomen and menstrual complaints, even without amenorrhoea, ectopic pregnancy should be ruled out. Treating reproductive tract infections / PID and offering contraceptives will decrease the incidence of ectopic pregnancy. Medical and paramedical staff should do the timely referral to higher centres

HYSTEROSALPINGOGRAPHY: TECHNIQUE AND APPLICATIONS (VIEW)

Hysterosalpingography (HSG) is the radiographic evaluation of the uterine cavity and fallopian tubes after the administration of a radio-opaque medium through the cervical canal. The first HSG was performed in 1910 and was considered to be the first special radio¬logic procedure. A properly performed HSG can de¬tect the contour of the uterine cavity and the width of the cervical canal. Further contrast medium injection will outline the cornua isthmic and ampullary portions of the tubes, and will show the degree of spillage. If a properly performed HSG shows no uterine cavity abnormality, it is very unlikely that other modalities would do so. Although this procedure is considered diagnostic, there may also be a possible therapeutic benefit from the flushing effect. Indications and Contraindications HSG is used predominantly in the evaluation of in-fertility. Despite the arrival of newer imaging modalities, HSG still remains the best procedure to image the fallopi¬an tubes. Although evaluating feminine infertility, with or without the presence of repeated miscarriages, is the main indication for this method, it can also be used in other cas-es, such as pain in the pelvis tract, congenital or anatomic abnormalities, anomalies of the menstrual cycle, and ab-normal menses. Also, it is sometimes used as a preoper-ative control for women who are about to have uterine or tubal surgery. Soares and coworkers showed that HSG had a sensitivity of 58% and a positive-predictive value of 28.6% for polypoid lesions, and a sensitivity of 0% for endometrial hyperplasia. The same study showed HSG to have a sensitivity of 44.4% for uterine malformations, and a sensitivity of 75% for the detection of intrauterine adhesions. The main contraindication of the examination is possible pregnancy. This contraindication can be avoid¬ed by performing the examination before the ovulation phase, between the 7th to 10th day of the menstrual cycle. Because of the scattering risk, the examination should be avoided when there is active intrapelvic inflammation. Another contraindication is vaginal or uterine bleeding because of the risk of unrestrained bleeding, which could lead to transfusion or surgical recovery procedures. Fi¬nally, the examination should not be performed in cases of severe cardiac or renal deficiency, or in cases of recent uterine or tubal surgery. Technique Patient Preparation The procedure is performed in the first half of the menstrual cycle following cessation of bleeding. The endometrium is thin during this proliferative phase, which facilitates better image interpretation and should also ensure that there is no pregnancy. The patient is asked to refrain from unprotected sexual intercourse from the date of her period until after the investigation to be certain there is no risk of pregnancy. Examination in the second half of the cycle is avoided because the thickened secretory-phase endometrium increases the risk of venous intravasation and may cause a false-pos¬itive diagnosis of cornual occlusion. Antibiotics might be required 1 day before and for a few days after the examination if previous inflamma¬tions are present in the patient’s clinical history. Antibiotics are required after the examination when the maneuvers are fairly sanguineous or if the fallopian tubes present a certain degree of dilation. The suggest¬ed antibiotic regimen is metronidazole 1 g rectally at the time of the procedure, plus doxycycline 100 mg twice daily for 7 days.Steroid (prednisolone) premed¬ication is prescribed in asthmatics when intravenous contrast is used; there-fore, it is reasonable to do the same for HSG because intravasation is also possible from this procedure. Catheterization Technique For the catheterization technique, the patient is placed on the fluoroscopic machine in a gynecologic examination position. After cleaning the external gen¬ital area with antiseptic solution, the vagina is dilated by a gynecologic dilator. The cervix is localized and cleansed with iodine solution. Afterward, the uterine cervix is straightened by one (at the 12 o’clock posi¬tion) or two (at the 9 and 3 o’clock positions) surgi¬cal forceps exercising a degree of pulling. Next, the outside uterine cervix ostium is catheterized. The catheterization can be performed in two ways. In the authors’ country, a salpinographer with a bell-shaped end (diameter depends on the case) is pushed through the vagina and fits in the external uterine cervix osti¬um. In the second technique, the salpingographer has a plastic cup-shaped end that is fitted to the external uterine cervix ostium, creating a void phenomenon. In both techniques, there is a syringe with iodinated hydrosoluble contrast medium at the other end of the salpingographer. The vagina dilator is taken off after catheterization of the external uteri cervix ostium and before administration of the contrast medium. Contrast Media In the past, oil-soluble contrast media were mainly used. Today, we use all available iodinated hydrosol¬uble contrast media. According to international liter¬ature, the use of oil-soluble contrast media increases the pregnancy rate and contributes to a decrease in conception time after the salpingography is performed. However, Spring and coworkers found that there is no evidence that the choice of the contrast material affects the rate of term pregnancy. Moreover, they reported that oil-soluble contrast media may promote granulo¬matous inflammation in the presence of obstructed or inflamed fallopian tubes. Radiological Views One conventional radiograph of the pelvis (on a 24¬30 cm radiologic film) is necessary before the contrast medium is administrated into the uterine cavity so that possible intrapyelic masses or calcifications will not complicate interpretation of the images. A metallic marker is placed over one side of the pelvis to indicate the right or left side of the patient. Next, the examina¬tion is performed under fluoroscopic control so that ra¬diographs can be taken during the filling of the uterine cavity (usually 2-3 cm of contrast medium is sufficient) and again during the filling of the fallopian tubes. Final¬ly, after the removal of the salpingographer, we radio¬graphically check the presence of contrast medium in the peritoneal cavity. The total amount of injected con¬trast medium should not exceed 10 mL. Additional spot radiographs are obtained to document any abnormality that is seen. Before the first radiograph, we also fluoro- scopically check the reflux of the contrast medium. Complications The two most common complications of HSG are pain and infection. These and other complications and side effects are summarized below. • Uterine contractions and discomfort due to the introduction of contrast medium into the uterine cavi¬ty: The most common type of pain referenced is subab¬dominal colic caused by dilation of the uterine cavity. A more diffuse pain, caused by irritation of the peri¬toneum due to the contrast medium, has also been re¬ported. Pain can be minimized by slowly injecting the contrast medium and using isosmolar contrast agents. • Postprocedural infection: Spreading and gener-alization of intrapyelic inflammation may happen in cases of chronic inflammation and hydrosalpinges, or after severe uterine injury caused by the examination maneuver. • Vasovagal reaction: A possible reaction to ma-nipulation of the cervix or inflation of a conclusion balloon in the cervical canal. • Traumatic elevation of endometrium by the in¬serted cannula: A complication which does not cause significant consequences. • Uterine perforation and tubal rupture: These complications are very rare. • Venous or lymphatic intravasation of contrast me-dia: With a water-based contrast medium there is no ad-verse effect on the patient, but it can make interpretation of the image difficult. It occurs more commonly in the presence of fibroids or tubal obstruction. Extravasation of the contrast medium could occur if the contrast me¬dium is administered too quickly, if the endometrium is injured during the catheterization, or if the examination is performed during menstruation. Extravasation is also possible when common or special inflammations of the endometrium are present due to the intercourse rate be-tween the uterine vein and the ovarian veins. • Allergic reaction to contrast media: Such a reac¬tion is very uncommon with the use of the low-osmolar nonionic contrast agents currently available. • Radiation exposure to the ovaries: Exposure is minimal and can be reduced if the proper technique is utilized. Normal Findings On face radiographs, the uterine cavity has a nor¬mal trigonal shape and the apex of the triangle corre¬sponds to the isthmus, which is nearly 3.7 cm wide. The apex is pointed downwards and connected to the internal ostium of the cervix uteri, which is 2.5 cm in total length. The base of triangular uterine cavity is the fundus, which can be concave, flattened, or slightly convex. On both sides of its base, in the area of the lateral horns, the two fallopian tubes are drowned. The fallopian tubes are separated into three segments: isth¬mus (attached to the uterus, not imaged in several cas¬es), ampullary (in the middle, the longest and widest segment), and bell-shaped (to the distal end). There are two ostiums: the internal or uterine, and the external or abdominal. From the abdominal ostium, the con¬trast medium disperses and diffuses into the peritone¬al cavity. Remaining contrast medium in the furrows of the peritoneum can be observed up to 3 hours after administration. Very often, the contrast medium in the rectouterine pouch of the peritoneum (Douglas’ space) can demonstrate the profile of the coordinate ovary. Congenital Uterus Anomalies Congenital uterus anomalies are caused by incom¬plete junction of the paramesonephric ducts (Muller ducts), or Extravasations of the contrast medium. The true incidence and prevalence of mullerian duct anomalies are difficult to assess. Examination of different patient populations, nonstandardized clas¬sification systems, and differences in diagnostic data acquisition has resulted in widely disparate estimates, with a reported prevalence that ranges from 0.16 to 10%. As a result of selection bias, a prevalence of 8 to 10% has been reported in women being evaluated with HSG because of recurrent pregnancy loss. The overall data suggest that the prevalence both in women with normal fertility and in women with infertility is approximately 1%, and the prevalence in women with repeated pregnancy loss is approximately 3%. While the majority of women with mullerian duct anomalies have little problem conceiving, they have higher associated rates of spontaneous abortion, pre¬mature delivery, and abnormal fetal position and dys¬tocia at delivery. Most studies report an approximate frequency of 25% for associated reproductive prob¬lems, compared with 10% in the general population. Primary infertility in these women usually has an ex¬tra uterine cause and is not generally attributable to mullerian duct anomalies alone. Additionally, cervical incompetence has been reported to be associated with these anomalies. According to the American Society of Reproduc¬tive Medicine, there are seven different classes of mul¬lerian duct anomalies: Class I: Segmental agenesis or variable degrees of uterovaginal hypoplasia. The anomaly can be detected, because of the amenorrhea, before HSG is performed. Class II: Unicornuate uteri that represent partial or complete unilateral hypoplasia. In rare cases of degen-eration of the mesonephric duct, the uterine cavity ap¬pears monocular when imaged, placed right or left of the middle line. The unicornuate uterus contacts only the coordinate fallopian tube. Class III: Didelphys uterus. This is a rare abnor¬mality that results from complete nonfusion of the mullerian ducts, and includes the duplication of the uterine cavity, cervix neck, and vagina. Rarely, this uterus has a single vagina. Class IV: Bicornuate uterus that demonstrates incomplete fusion of the superior segments of the uterovaginal canal. The uterine cavity is divided in two; each half has a narrow-length shape and stands apart from the other. Class V: Septate uteri that represent partial or com¬plete nonresorption of the uterovaginal septum. Class VI: Arcuate uterus resulting from nearly complete resorption of the septum. Along with the pre¬vious anomaly, these are the most common congenital anomalies (50%) in cases detecting female infertility. Class VII: Anomalies that comprise sequelae of in utero diethyloestradiol exposure. Another congenital anomaly, caused by inadequate hormonic stimulation as a fetus, is small uterine cavi¬ty size with normal vaginal length. This is a common finding in cases of female infertility. Abnormal Findings Fibromyomas While fibromas are diagnosed by suprapubic ultra-sound, submucosa fibromyomas are imaged as smooth filling defects in the uterine cavity. Differential diagno¬sis must be made from endometrial polyps or possible pregnancy. Small intramural fibromyomas do not distort the endometrial cavity and are not visualized on HSG. Subserous fibromyomas can provoke smooth filling de-fects or smooth repression of the fallopian tubes only if they are located in the lateral walls of the uterus. Endometrial Polyps Endometrial polyps are focal overgrowths of the endometrium. They usually manifest as well-defined filling defects and are best seen during the early filling stage. Small polyps may be obscured when contrast material completely fills the uterine cavity and may be indistinguishable from a small submucosal myoma. Sonohysterography has become the preferred method of imaging endometrial polyps. Internal Endometriosis (Adenomyosis) Adenomyosis is caused by the presence of ectopic islets of active endometrium in the muscularis wall of the uterus. It is usually imaged as a pointed projection of 2 to 3 mm length, perpendicular to the uterine wall after contrast medium administration. Rarely, this is imaged as a sack-shaped projection filled by contrast medium, 4 mm to 1 cm in length. Differential diag¬nosis should include the hyperplasia of the endome¬trium and the entrance of the contrast medium in the myometrium or in the nutrient arteriole of submucosa fibromyomas. Uterine Cancer Uterine cancer manifests as an irregular filling de¬fect, but is rarely diagnosed by the HSG method. Intrauterine Adhesions Intrauterine adhesions are most commonly caused by endometrial trauma of curettage. They are also seen in patients with chronic endometriosis due to tubercu¬losis. Genital tuberculosis primary affects the fallopian tubes, and 50% of patients with tubal disease also have a uterine abnormality. Intrauterine adhesions manifest as irregular filling defects, most commonly as linear filling defects arising from one of the uterine walls. Hydrosalpinx HSG is the best method for visualizing and eval¬uating the fallopian tubes. Hydrosalpinx is a common finding that results from a previous inflammation of the fallopian tubes (salpingitis). This is usually the se¬quelae of distal tubal occlusion, leading to dilation of the proximal segment. The radiologic image shows a dilated lumen in one or more spots, and the contrast medium will not make its way to the peritoneal cavity Tuberculated Salpingitis This entity usually causes distant fallopian tube end obliteration. In extensive infections, multiple con¬strictions along the course of fallopian tube can form, resulting in areas of dilation and stenosis. Abnormal uterine and vaginal profiles are observed in cases of widespread infection. Salpingitis Isthmica Nodosa Salpingitis isthmica nodosa is a disease of un¬known etiology, characterized by multiple small out- pouchings or diverticula affecting one or both fallopian tubes. It is presumably caused by pelvic inflammatory disease or endometriosis and is associated with ectopic pregnancy and infertility. Nondrawing of the Fallopian Tubes This is the most common finding during the exam-ination and is usually caused by poor technique, spasm, or obliteration of the fallopian tube. Poor technique in¬cludes imperfect straightening of the external cervical ostium or an inadequate amount of contrast medium in the uterine cavity. The cornual portion of the fallopian tube is encased by the smooth muscle of the uterus and, if there is a spasm of the muscle during HSG, one or both tubes may not fill. Using radiography, tubal spasm cannot be distinguished from tubal occlusion. This could be avoided by progressive administration of the contrast medium or, when the spasm occurs, administration of a spasmolytic agent to relieve spasm, helping differentiate cornual spasm from true occlusion. Obliteration is usu¬ally caused by previous inflammation or uterine surgery and manifests as nonopacification or abrupt cutoff of the fallopian tube with no free intraperitoneal spillage. External Adhesions External adhesions occur secondary to previous inflammation or surgery, similar to the causes of tubal occlusion. Peritubal adhesions prevent contrast materi¬al from flowing freely around the bowel loops as seen in normal cases, and most commonly manifest as loc- ulation of the contrast material around the ampullary portion of the tube. Conclusion. HSG remains the front-line imaging modality in the investigation of infertility. It is an ac¬curate means of accessing the uterine cavity and tubal patency, but has a low sensitivity for the diagnosis of pelvic adhe¬sions, which is why it cannot replace laparoscopy. It requires knowledge of the female anatomy as well as skillful technique in order to avoid pitfalls and misin¬terpretations.Кафедра акушерства та гінекологі