PUSHPAGHNI JATAHARINI IN MODERN SCIENTIFIC PERSPECTIVE: A REVIEW

Jataharini has described by Acharya Kashyapa in Revati Kalpaadhyaya of Kalpasthana in Kashyapa Samhita. Jataharini is a group of disease that affects the women during their different stages of life. It not only affects the women but also their foetuses, neonates and children. Pushpaghni Jataharini is one of them which affect the women at their reproductive age. Adharma (unrighteousness) is a most important cause for affliction by Jataharini as described by Acharya Kashyapa. Adharma may be said to some extent as lifestyle changes in present time. This lifestyle changes due to modernization has given rise to many lifestyle disorders like diabetes, cardiovascular diseases and polycystic ovarian disease etc. PCOS is one of the most common lifestyle disorders occurring in females. PCOS is emerging as a burning disease affecting a growing number of urban Indian women. A recent rise in PCOS cases in urban India may be due to modernization, stress and lifestyle changes. By analyzing the symptoms of both Pushpaghini Jataharini and PCOS, it is found that both are similar to some extent. In ancient time, Acharya Kashyapa has considered spiritual power responsible for disease. The causation of disease is not defined on scientific role of Doshas. An effort is made in this article to give some scientific reasons why Pushpaghini Jataharini is close to the Polycystic Ovarian Syndrome. As India has been labelled as the ‘diabetic capital of the world’ due to an alarming increase in the number of cases of both diabetes and metabolic syndrome, it is possible that there may be an increasing number of cases of PCOS as well as because PCOS is also a disorder of insulin metabolism. Thus PCOS is a syndrome showing an alarming rise in India and adding economic health burden of the country

Flame-retardant Cotton Fabric Through Graft Copolymerisation

In an attempt to impart flame-retarding properties to the cotton fabric, post-graftingphosphorylation reactions on grafted cotton fabric were carried out. Photochemical graftcopolymerisation of 4-vinyl pyridine (4-VP) onto cotton fabric using benzophenone asphotosensitiser was carried out. Maximum percentage of grafting Pg, (18.50 %) was obtainedunder optimum  conditions; irradiation time 75 min, 0.5 ml of  benzophenone,  [4-VP]=748.71 x10-2 mole/l and 5 ml of water in the reaction mixture. Aliphatic alcohols of varying chain lengthdecreased percentage of grafting. The pendant pyridine rings of the 4-VP grafted cotton fabricwere converted to pyridinium chloride followed by the reaction with acrylamide to give 2-amido-ethylpyridiniumchloride. This was subjected to phosphorylation reaction with PCl3/petroleumether. The phosphorylated grafted cotton fabric burns only in the presence of flame with veryslow propagation of the flame (only 3.8 cm2) was found to burn of the total area of 147 cm2 with0.12 g of the ash content. Characterisation of gray cotton fabric and modified cotton fabric wascarried out by FTIR, thermogravimetric analysis, crease recovery, and moisture absorption studies

INTERLEUKIN-17INHIBITION WITH SECUKINUMAB IMPROVES SUDOMOTOR DYSFUNCTION IN PSORIATIC ARTHRITIS

Psoriatic arthritis (PsA) is a relapsing inflammatory disease, most commonly a seronegative oligoarthritis found in patients with psoriasis, characterized by the absence of rheumatoid factor in serum, with differentiating features of distal joint involvement and in extreme cases of arthritis mutilans (which is a destructive form of PsA). Cardiovascular autonomic and peripheral sympathetic neuropathy occurs in PsA. However, there is no specific treatment recommendation for autonomic neuropathy (AN) in psoriatic diseases. Secukinumab, a recently approved therapeutic advancement for psoriasis and psoriatic arthritis, is an immunoglobulin G (IgG) 1k fully monoclonal antibody that selectively inhibits the effector function of interleukin (IL)-17A. Its effect on sudomotor dysfunction in PsA has not yet been reported. This is the first reported observation of improvement in peripheral sympathetic autonomic neuropathy with secukinumab in PsA. We report a case of a 52-year-old male with PsA on methotrexate 15 mg/week with severe disease activity treated with the addition of subcutaneous secukinumab 150 mg once a week for 5 w followed by once a month dose. We found significant improvement in sudomotor dysfunction after 4 and 8 w of treatment

Radiochemical Graft Copolymerisation of 2-Hydroxy Ethylmethacrylate onto Polyamide-6, 6-Nylon

Polyamide-6,6-nylon has been modified by radiation-induced graft copolymerisation of 2-hydroxy ethylmethacrylate (2-HEMA) in nonaqueous medium (ethanol). No homopolymer formation was observed during grafting. Optimum conditions for affording maximum percentage of grafting have been evaluated. Maximum percentage of grafting (170 per cent) was obtained at a total dose of 0.74 x 10 to the power 4 Gy using 2-HEMA (8 x 10 to the power-3 moles) in ethanol (10 ml). The grafted samples were characterised by thermogravimetric analysis and it was observed that grafting slightly decreased the thermal stability of the polyamide-6,6 fibre. Dyeing properties of polyamide-6,6 fibre and grafted fibre have also been investigated

Phytochemical analysis using GC-FID, FPLC fingerprinting, antioxidant, antimicrobial, anti- inflammatory activities analysis of traditionally used Eucalyptus globulus essential oil

Eucalyptus globules is an widely distributed in tropical and subtropical regions. It has been widely used as folk medicine, and folk cosmetic owing to its antioxidant values. Despite its importance, phytochemical and pharmacological studies remain infancy. This study was aimed at extraction of essential oil by steam-distillation and evaluation of bioactive components, antioxidant, antimicrobial, anti-inflammatory activities along with analysis by UV-VIS, FT-IR and Fluorescent techniques. Fast protein liquid chromatography (FPLC) was used to confirm the presence of polyphenols. Different antioxidant activities like DPPH., ABTS.+, .OH, superoxide, nitric oxide and reducing power of the essential oil. Essential oil was analyzed by UV-VIS, FT-IR and Fluorescent techniques. In vitro antimicrobial activity was also monitored. FT-IR fingerprint qualitative analysis was performed using commercial standards. Considerable amount of flavonoids were detected in essential oil.  Oil exhibited considerable scavenging activities of ABTS.+, .OH, superoxide, nitric oxide and reducing power. UV-VIS, FT-IR analysis revealed the presence of polyphenolics in essential oil. Fluorescent spectroscopy revealed the presence of fluorophores in essential oil. FPLC and FT-IR fingerprint analysis revealed the presence of bioactive constituents like rutin, tannic acid, vanillic acid and ascorbic acid in the essential oil. A strong anti-inflammatory activity of oil was observed using fluorescent spectroscopy. An appreciable in vitro antibacterial activity against gram-negative bacteria like Acetobacter aceti and Pseudomonas aeruginosa was detected. The data provides the scientific support to the use of essential oil from Eucalyptus globules as a potent herbal source of bioactive compounds possessing natural antioxidant activities in food and pharmaceutical industries

Evaluating Quality of Matrimonial Websites: Balancing Emotions with Economics

There are a plethora of studies evaluating the quality of websites on functional and design-related aspects such as usability and visual parameters. The majority of these studies are related to e-commerce websites where individuals make decision largely relying on economic parameters. However, matrimonial websites are unique, as the decisions involve both economic and non-economic parameters. Therefore, this study aims to propose a framework to evaluate quality of matrimonial websites by incorporating contextual factors and examine differences among different groups of users. This study proffers a website evaluating framework considering non-economic and emotion based factors from the information systems (IS) success model and the search match interaction (SMI) framework. The study proposes a hybrid model of multi-criteria decision-making techniques—namely Fuzzy-AHP and ranking models such as evaluation based on distance from average solution (EDAS), technique for order of preference by similarity to ideal solution (TOPSIS), and complex proportional assessment (COPRAS). The results indicate that the context-specific factors related to search and matchmaking options are the most preferred parameters for evaluation. Males and females have been found to differ in their preferences related to service quality and price. Next, the study compares the performance of three ranking models, namely EDAS, TOPSIS, and COPRAS. The first and second models provide similar results, while the rankings obtained through COPRAS differ slightly. The study contributes towards website evaluation literature by highlighting the importance of contextual factors while evaluating the matrimonial websites and the differences among preferences of the users