Are Preferential Tariffs Utilized? Evidence from Australian Imports, 2000-9

Preferential tariff rates are often not utilized by qualified beneficiaries. Two reasons are complex rules of origin and erosion of preference margins as a result of multilateral trade liberalization. Our paper contributes to this research by providing evidence from high-quality disaggregated customs data of the utilization rate for Australia's preferential trading arrangements in the period 2000-9. A pattern of low ratios of imports receiving preferential tariff treatment to the total value of bilateral imports applies to all six of Australia's PTAs. Over half of Australian imports from New Zealand, the Pacific Island Forum economies, Thailand and Chile claimed preferential treatment in 2000, but all had lower utilization rates by 2009. This is primarily because of the increasing number of zero MFN tariff lines. Where MFN tariffs are positive, preferential tariffs are utilized and preferred trading partners pay lower customs duties. Positive utilization rates indicate that tariff preferences do have an impact, and at a minimum the exporters claiming the preferential tariff rate are better off than they would be in its absence, but by themselves utilization rates shed no light on the size of the impact on trade flows or on economic wellbeing.preferential tariffs, trade liberalization, preference erosion

Sedative-Hypnotic Prescribing in the United States from 1993 to 2010: Recent Trends and Outcomes

BACKGROUND: Studies show sedative-hypnotic medications (benzodiazepines [BZDs] and non-benzodiazepine receptor agonists [nBZRAs]) to be associated with adverse outcomes. This dissertation examined prescribing trends of these medications from 1993-2010, and comprised of three studies: study 1 examined trends in prescribing of sedative-hypnotics, study 2 examined physician practice style as a contributing factor for trends seen in study 1, and study 3 examined visits involving sedative-hypnotics in emergency departments (EDs). METHODS: Data for studies 1 and 2 came from the National Ambulatory Medical Care Survey (NAMCS). Study 1 analyzed trends in the proportion of visits from 1993-2010 where a BZD and/or nBZRA was prescribed. Study 2 examined trends in the proportion of physicians prescribing BZDs and nBZRAs, as well as the predicted number of visits (based on regression models) that a BZD or nBZRA was prescribed among BZD and nBZRA prescribers respectively. Data for study 3 came from the Drug Abuse Warning Network. Analyses used logistic regression to determine the association between ED visits involving BZDs and/or nBZRAs and the seriousness of visit outcomes. RESULTS: From 1993-2010, we found increases in the proportion of visits resulting in a prescription for a BZD (from 2.6% to 4.4%, p<0.001) and a nBZRA (from 0% to 1.4%, p<0.001), as well as the co-prescribing of these agents at the same visit (from 0% to 0.4%, p<0.001). Over this same period, we observed increases in the proportion of NAMCS physicians each year who prescribed BZDs (from 23.8% to 44.4%, p<0.001) and nBZRAs (from 1.0% to 25.8%, p<0.001), and in the predicted number of NAMCS visits that an nBZRA was prescribed among nBZRA prescribers (from 1.33 to 1.72, p<0.001). ED visits involving BZDs without nBZRAs and BZDs + nBZRAs were associated with increased odds for more serious outcomes compared to visits involving neither medication (odds ratio [OR]=1.34, 95% confidence interval [CI]=1.20-1.50 for BZDs without nBZRAs; OR=3.15, 95% CI=2.01-4.94 for BZDs + nBZRAs). CONCLUSIONS: Efforts to encourage safe prescribing of sedative-hypnotics, and greater dissemination of behavioral treatments for insomnia and anxiety disorders, could have the potential to decrease the public health burden attributed to prescribing of these medications

Ritual Machines I & II: Making Technology at Home

Changing patterns of both work-related mobility and domestic arrangements mean that ‘mobile workers’ face challenges to support and engage in family life whilst travelling for work. Phatic devices offer some potential to provide connection at a distance alongside existing communications infrastructure. Through a bespoke design process, incorporating phases of design ethnography, critical technical practice and provotyping we have developed Ritual Machines I and II as material explorations of mobile workers’ lives and practices. In doing this we sought to reflect upon the practices through which families accomplish mobile living, the values they place in technology for doing ‘family’ at a distance and to draw insights in to the potential roles of digital technology in supporting them. We frame the design of our phatic devices in discussion of processes of bespoke design, offer advice on supporting mobile workers when travelling and articulate the values of making a technology at home when designing for domestic and mobile settings

Reconstructing Deconstruction: High-Velocity Cloud Distance Through Disruption Morphology

We present Arecibo L-band Feed Array 21-cm observations of a sub-complex of HVCs at the tip of the Anti-Center Complex. These observations show morphological details that point to interaction with the ambient halo medium and differential drag within the cloud sub-complex. We develop a new technique for measuring cloud distances, which relies upon these observed morphological and kinematic characteristics, and show that it is consistent with H-alpha distances. These results are consistent with distances to HVCs and halo densities derived from models in which HVCs are formed from cooling halo gas.Comment: 8 pages, 2 figures, 1 tabe, Accepted to Ap

Ice nucleation efficiency of natural dust samples in the immersion mode

A total of 12 natural surface dust samples, which were surface-collected on four continents, most of them in dust source regions, were investigated with respect to their ice nucleation activity. Dust collection sites were distributed across Africa, South America, the Middle East, and Antarctica. Mineralogical composition has been determined by means of X-ray diffraction. All samples proved to be mixtures of minerals, with major contributions from quartz, calcite, clay minerals, K-feldspars, and (Na, Ca)-feldspars. Reference samples of these minerals were investigated with the same methods as the natural dust samples. Furthermore, Arizona test dust (ATD) was re-evaluated as a benchmark. Immersion freezing of emulsion and bulk samples was investigated by differential scanning calorimetry. For emulsion measurements, water droplets with a size distribution peaking at about 2 µm, containing different amounts of dust between 0.5 and 50 wt % were cooled until all droplets were frozen. These measurements characterize the average freezing behaviour of particles, as they are sensitive to the average active sites present in a dust sample. In addition, bulk measurements were conducted with one single 2 mg droplet consisting of a 5 wt % aqueous suspension of the dusts/minerals. These measurements allow the investigation of the best ice-nucleating particles/sites available in a dust sample. All natural dusts, except for the Antarctica and ATD samples, froze in a remarkably narrow temperature range with the heterogeneously frozen fraction reaching 10 % between 244 and 250 K, 25 % between 242 and 246 K, and 50 % between 239 and 244 K. Bulk freezing occurred between 255 and 265 K. In contrast to the natural dusts, the reference minerals revealed ice nucleation temperatures with 2–3 times larger scatter. Calcite, dolomite, dolostone, and muscovite can be considered ice nucleation inactive. For microcline samples, a 50 % heterogeneously frozen fraction occurred above 245 K for all tested suspension concentrations, and a microcline mineral showed bulk freezing temperatures even above 270 K. This makes microcline (KAlSi3O8) an exceptionally good ice-nucleating mineral, superior to all other analysed K-feldspars, (Na, Ca)-feldspars, and the clay minerals. In summary, the mineralogical composition can explain the observed freezing behaviour of 5 of the investigated 12 natural dust samples, and partly for 6 samples, leaving the freezing efficiency of only 1 sample not easily explained in terms of its mineral reference components. While this suggests that mineralogical composition is a major determinant of ice-nucleating ability, in practice, most natural samples consist of a mixture of minerals, and this mixture seems to lead to remarkably similar ice nucleation abilities, regardless of their exact composition, so that global models, in a first approximation, may represent mineral dust as a single species with respect to ice nucleation activity. However, more sophisticated representations of ice nucleation by mineral dusts should rely on the mineralogical composition based on a source scheme of dust emissions

Participatory Development of an Image-Based Communication Aid for Migrant Patients and Emergency Nurses

Language barriers hamper or delay delivery of urgent and emergency care to migrant children when they or their parents don’t speak any of the languages commonly spoken in Switzerland. In such situations, nurses often fall back to use ad hoc communication aids, including translation apps and visual dictionaries, to collect information about a patient’s medical history. In this paper, we report on the participatory design process for a novel image-based communication aid. It is specifically tailored to the needs of migrant patients and nurses within Swiss pediatric clinics. We collected requirements in surveys and in-depth interviews with pediatric nurses. A prototype app was developed and tested with users in a scenario-based usability test. The results clearly show that the images developed, especially for symptoms, accidents or nutrition and excretion, are well comprehensible for triage and anamnesis. In contrast, a temporal classification or chronological occurrence of health incidents is difficulty to express with images

Direct measurement of protein-protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells

Protein-protein interactions are essential to ensure timely and precise recruitment of chromatin remodellers and repair factors to DNA damage sites. Conventional analyses of protein-protein interactions at a population level may mask the complexity of interaction dynamics, highlighting the need for a method that enables quantification of DNA damage-dependent interactions at a single-cell level. To this end, we integrated a pulsed UV laser on a confocal fluorescence lifetime imaging (FLIM) microscope to induce localized DNA damage. To quantify protein-protein interactions in live cells, we measured Förster resonance energy transfer (FRET) between mEGFP- and mCherry-tagged proteins, based on the fluorescence lifetime reduction of the mEGFP donor protein. The UV-FLIM-FRET system offers a unique combination of real-time and single-cell quantification of DNA damage-dependent interactions, and can distinguish between direct protein-protein interactions, as opposed to those mediated by chromatin proximity. Using the UV-FLIM-FRET system, we show the dynamic changes in the interaction between poly(ADP-ribose) polymerase 1, amplified in liver cancer 1, X-ray repair cross-complementing protein 1 and tripartite motif containing 33 after DNA damage. This new set-up complements the toolset for studying DNA damage response by providing single-cell quantitative and dynamic information about protein-protein interactions at DNA damage sites

Patterns of concurrent substance use among nonmedical ADHD stimulant users: Results from the National Survey on Drug Use and Health

Aims: To examine patterns of concurrent substance use among adults with nonmedical ADHD stimulant use. Methods: We used latent class analysis (LCA) to examine patterns of past-year problematic substance use (meeting any criteria for abuse or dependence) in a sample of 6103 adult participants from the National Surveys on Drug Use and Health 2006–2011 who reported past-year nonmedical use of ADHD stimulants. Multivariable latent regression was used to assess the association of socio-demographic characteristics, mental health and behavioral problems with the latent classes. Results: A four-class model had the best model fit, including (1) participants with low probabilities for any problematic substance use (Low substance class, 53.3%); (2) problematic users of all types of prescription drugs (Prescription drug class, 13.3%); (3) participants with high probabilities of problematic alcohol and marijuana use (Alcohol–marijuana class, 28.8%); and (4) those with high probabilities of problematic use of multiple drugs and alcohol (Multiple substance class, 4.6%). Participants in the 4 classes had distinct socio-demographic, mental health and service use profiles with those in the Multiple substance class being more likely to report mental health and behavioral problems and service use. Conclusion: Nonmedical users of ADHD stimulants are a heterogeneous group with a large subgroup with low prevalence of problematic use of other substances. These subgroups have distinct patterns of mental health comorbidity, behavior problems and service use, with implications for prevention and treatment of nonmedical stimulant use

Omega-3 polyunsaturated fatty acids and bronchial inflammation in grass pollen allergy after allergen challenge

SummaryRatioAsthma is a major public health problem, with bronchial inflammation as the therapeutic target. The role of dietary fish oil derived polyunsaturated fatty acids (PUFAs) in allergic inflammation is controversial. Most asthmatics suffer from mild disease and non-pharmacologic interventions are attractive. This study investigates the anti-inflammatory potential of nutritional PUFAs in an experimentally induced bronchial inflammation.MethodsWe examined 38 grass pollen allergic asthmatics and 19 controls. History of dietary PUFA intake was compared with levels of PUFAs in erythrocyte membranes, and stratified according to low (25th quartile; Q25) and high (75th quartile; Q75) ratios of omega-3 (n-3) to omega-6 (n-6) PUFAs as a surrogate for anti-inflammatory (Q75) or proinflammatory (Q25) effects. Bronchial inflammation was simulated with one-step inhalation of grass pollen. Bronchial response (exhaled nitric monoxide, eNO as surrogate for inflammation, decrease of FEV1) was correlated with levels of PUFAs in erythrocyte membranes.ResultsRatios of n-3/n-6 PUFA were significantly lower in asthmatics than in healthy controls. Levels of eNO were significantly higher in Q25 asthmatics than in Q75 asthmatics (p = 0.040). There was a trend of higher bronchial hyperreactivity in Q25 asthmatics (median PD20 0.27 vs. 0.14; n.s.), induced by specific bronchial challenge with grass pollen (FEV1 decrease 16.7 vs. 23.1%; n.s.).ConclusionWhen stratifying for erythrocyte membrane PUFA content as a surrogate for alimentary intake, we found mild effects on bronchial allergic inflammation. Future intervention studies with pharmacological PUFA doses appear suitable to clarify dietary PUFA role as an adjunctive intervention to the established treatment of asthma.ClinicalTrials.gov No. NCT00519740

Prospectus, March 9, 1989

https://spark.parkland.edu/prospectus_1989/1004/thumbnail.jp