An Exceptional Sector for F-theory GUTs

D3-branes are often a necessary ingredient in global compactifications of F-theory. In minimal realizations of flavor hierarchies in F-theory GUT models, suitable fluxes are turned on, which in turn attract D3-branes to the Yukawa points. Of particular importance are ``E-type'' Yukawa points, as they are required to realize a large top quark mass. In this paper we study the worldvolume theory of a D3-brane probing such an E-point. D3-brane probes of isolated exceptional singularities lead to strongly coupled N = 2 CFTs of the type found by Minahan and Nemeschansky. We show that the local data of an E-point probe theory determines an N = 1 deformation of the original N = 2 theory which couples this strongly interacting CFT to a free hypermultiplet. Monodromy in the seven-brane configuration translates to a novel class of deformations of the CFT. We study how the probe theory couples to the Standard Model, determining the most relevant F-term couplings, the effect of the probe on the running of the Standard Model gauge couplings, as well as possible sources of kinetic mixing with the Standard Model.Comment: v2: 32 pages, 1 figure, references added, appendix remove

Sommerfeld Enhancements for Thermal Relic Dark Matter

The annihilation cross section of thermal relic dark matter determines both its relic density and indirect detection signals. We determine how large indirect signals may be in scenarios with Sommerfeld-enhanced annihilation, subject to the constraint that the dark matter has the correct relic density. This work refines our previous analysis through detailed treatments of resonant Sommerfeld enhancement and the effect of Sommerfeld enhancement on freeze out. Sommerfeld enhancements raise many interesting issues in the freeze out calculation, and we find that the cutoff of resonant enhancement, the equilibration of force carriers, the temperature of kinetic decoupling, and the efficiency of self-interactions for preserving thermal velocity distributions all play a role. These effects may have striking consequences; for example, for resonantly-enhanced Sommerfeld annihilation, dark matter freezes out but may then chemically recouple, implying highly suppressed indirect signals, in contrast to naive expectations. In the minimal scenario with standard astrophysical assumptions, and tuning all parameters to maximize the signal, we find that, for force-carrier mass m_phi = 250 MeV and dark matter masses m_X = 0.1, 0.3, and 1 TeV, the maximal Sommerfeld enhancement factors are S_eff = 7, 30, and 90, respectively. Such boosts are too small to explain both the PAMELA and Fermi excesses. Non-minimal models may require smaller boosts, but the bounds on S_eff could also be more stringent, and dedicated freeze out analyses are required. For concreteness, we focus on 4 mu final states, but we also discuss 4 e and other modes, deviations from standard astrophysical assumptions and non-minimal particle physics models, and we outline the steps required to determine if such considerations may lead to a self-consistent explanation of the PAMELA or Fermi excesses.Comment: 31 pages, published versio

Retrovirus-Mediated Transduction of Cultured Epidermal Keratinocytes

Retrovirus-mediated gene transfer is an efficient means of introducing and expressing exogenous gene(s) in many cell types including keratinocytes. However, parameters of transduction and gene expression have not been systematically analyzed for keratinocytes. To carry out such a study we have transduced cultures of newborn foreskin cells with retroviral vectors that encode the genes for neomycin resistance (neor) and for beta-galactosidase (B-gal). The neor gene is a dominant selectable marker and the B-gal gene encodes a histochemically detectable product. Our key findings are the following: 1) all keratinocytes that form colonies can be successfully transduced at a viral titer greater than 5 × 106 colony-forming units/ml; 2) transduction is effected by integration of a single copy of retroviral DNA; 3) transduced cells are not at a growth disadvantage and, in fact, single clones of transduced keratinocytes can be expanded to yield over 109 cells, suggesting that stem cells are transduced; 4) whereas most transduced colonies exhibit B-gal staining in a high percentage of constituent cells, some colonies had a mosaic or sectored staining pattern; 5) expression of the non-selectable B-gal gene was somewhat greater in differentiated cells of the culture as compared to nondifferentiated precursors. The ability to transduce stem cells at a high efficiency and to follow expression of transduced genes in clonal progeny will allow lineage mapping in stratified epithelial tissues

Structural and Mechanical Analysis of Tectorial Membrane Tecta Mutants

AbstractThe tectorial membrane (TM) is an extracellular matrix of the cochlea whose prominent role in hearing has been demonstrated through mutation studies. The C1509G mutation of the Tecta gene, which encodes for the α-tectorin protein, leads to hearing loss. The heterozygote TM only attaches to the first row of outer hair cells (OHCs), and the homozygote TM does not attach to any OHCs. Here we measured the morphology and mechanical properties of wild-type, heterozygous, and homozygous Tecta TMs. Morphological analyses conducted with second- and third-harmonic imaging, scanning electron microscopy, and immunolabeling revealed marked changes in the collagen architecture and stereocilin-labeling patterns of the mutant TMs. The mechanical properties of the mutant TM were measured by force spectroscopy. Whereas the axial Young's modulus of the low-frequency (apical) region of Tecta mutant TM samples was similar to that of wild-type TMs, it significantly decreased in the basal region to a value approaching that found at the apex. Modeling simulations suggest that a reduced TM Young's modulus is likely to reduce OHC stereociliary deflection. These findings argue that the heterozygote C1509G mutation results in a lack of attachment of the TM to the OHCs, which in turn reduces both the overall number of OHCs that are involved in mechanotransduction and the degree of mechanotransduction exhibited by the OHCs that remain attached to the TM

Fast full-color computational imaging with single-pixel detectors

Single-pixel detectors can be used as imaging devices by making use of structured illumination. These systems work by correlating a changing incident light field with signals measured on a photodiode to derive an image of an object. In this work we demonstrate a system that utilizes a digital light projector to illuminate a scene with approximately 1300 different light patterns every second and correlate these with the back scattered light measured by three spectrally-filtered single-pixel photodetectors to produce a full-color high-quality image in a few seconds of data acquisition. We utilize a differential light projection method to self normalize the measured signals, improving the reconstruction quality whilst making the system robust to external sources of noise. This technique can readily be extended for imaging applications at non-visible wavebands

Spreading the Privacy Blanket: Differentially Oblivious Shuffling for Differential Privacy

In the shuffle model for differential privacy, $n$ users locally randomize their data and submit the results to a trusted “shuffler” who mixes the results before sending them to a server for analysis. This is a promising model for real-world applications of differential privacy, as several recent results have shown that the shuffle model sometimes offers a strictly better privacy/utility tradeoff than what is possible in a purely local model. A downside of the shuffle model is its reliance on a trusted shuffler, and it is natural to try to replace this with a distributed shuffling protocol run by the users themselves. While it would of course be possible to use a fully secure shuffling protocol, one might hope to instead use a more-efficient protocol having weaker security guarantees. In this work, we consider a relaxation of secure shuffling called differential obliviousness that we prove suffices for differential privacy in the shuffle model. We also propose a differentially oblivious shuffling protocol based on onion routing that requires only $O(n \log n)$ communication while tolerating any constant fraction of corrupted users. We show that for practical settings of the parameters, our protocol outperforms existing solutions to the problem in some settings

SoK: Why Johnny Can't Fix PGP Standardization

Pretty Good Privacy (PGP) has long been the primary IETF standard for encrypting email, but suffers from widespread usability and security problems that have limited its adoption. As time has marched on, the underlying cryptographic protocol has fallen out of date insofar as PGP is unauthenticated on a per message basis and compresses before encryption. There have been an increasing number of attacks on the increasingly outdated primitives and complex clients used by the PGP eco-system. However, attempts to update the OpenPGP standard have failed at the IETF except for adding modern cryptographic primitives. Outside of official standardization, Autocrypt is a "bottom-up" community attempt to fix PGP, but still falls victim to attacks on PGP involving authentication. The core reason for the inability to "fix" PGP is the lack of a simple AEAD interface which in turn requires a decentralized public key infrastructure to work with email. Yet even if standards like MLS replace PGP, the deployment of a decentralized PKI remains an open issue

Multi-Input Functional Encryption

\emph{Functional encryption} (FE) is a powerful primitive enabling fine-grained access to encrypted data. In an FE scheme, secret keys (``tokens\u27\u27) correspond to functions; a user in possession of a ciphertext \ct = \enc(x) and a token \tkf for the function~$f$ can compute $f(x)$ but learn nothing else about~$x$. An active area of research over the past few years has focused on the development of ever more expressive FE schemes. In this work we introduce the notion of \emph{multi-input} functional encryption. Here, informally, a user in possession of a token \tkf for an $n$-ary function $f$ and \emph{multiple} ciphertexts \ct_1=\enc(x_1), \ldots, \ct_n=\enc(x_n) can compute $f(x_1, \ldots, x_n)$ but nothing else about the~$\{x_i\}$. Besides introducing the notion, we explore the feasibility of multi-input FE in the public-key and symmetric-key settings, with respect to both indistinguishability-based and simulation-based definitions of security

Quasi-Periodic Occultation by a Precessing Accretion Disk and Other Variabilities of SMC X-1

We have investigated the variability of the binary X-ray pulsar, SMC X-1, in data from several X-ray observatories. We confirm the ~60-day cyclic variation of the X-ray flux in the long-term monitoring data from the RXTE and CGRO observatories. X-ray light curves and spectra from the ROSAT, Ginga, and ASCA observatories show that the uneclipsed flux varies by as much as a factor of twenty between a high-flux state when 0.71 second pulses are present and a low-flux state when pulses are absent. In contrast, during eclipses when the X-rays consist of radiation scattered from circumsource matter, the fluxes and spectra in the high and low states are approximately the same. These observations prove that the low state of SMC X-1 is not caused by a reduction in the intrinsic luminosity of the source, or a spectral redistribution thereof, but rather by a quasi-periodic blockage of the line of sight, most likely by a precessing tilted accretion disk. In each of two observations in the midst of low states a brief increase in the X-ray flux and reappearance of 0.71 second pulses occurred near orbital phase 0.2. These brief increases result from an opening of the line of sight to the pulsar that may be caused by wobble in the precessing accretion disk. The records of spin up of the neutron star and decay of the binary orbit are extended during 1991-1996 by pulse-timing analysis of ROSAT, ASCA, and RXTE PCA data. The pulse profiles in various energy ranges from 0.1 to >21 keV are well represented as a combination of a pencil beam and a fan beam. Finally, there is a marked difference between the power spectra of random fluctuations in the high-state data from the RXTE PCA below and above 3.4 keV. Deviation from the fitted power law around 0.06 Hz may be QPO.Comment: Accepted to ApJ. 33 pages including 11 figure

The Ursinus Weekly, March 6, 1969

Officers inducted; Emig emphasizes new responsibility • American dream, brotherhood highlight Festival of the Arts • USGA officers interviewed; Communication gap stressed • Placement interviews scheduled • 200 attend Lorelei; Fischer crowned king • Semi-formal ball highlights junior-senior weekend • Editorial: Potpourri - Or, Could this ever happen here? • State set to punish protestors; Laws threaten civil liberties • Letters to the editor • Remark • Lantern literary lapse termed titanic bomb • Staying out of uniform: A practical guide for the Ursinus male, part I • Whose risk? • Columnist proposes solution to UC\u27s dearth of black students • Albright draws Fifth Dimension • Racism symposium set for March 20 with Lincoln Univ. • Dorm lounges opened; Slacks rule slackened • Rice discusses status for Phi Beta Kappa • Ursinus grapplers rally to win over Drexel, 22-13 • New gym complex to include pool • Carson paces Bearettes over Gettysburg • Badminton team wins six in row • Trackmen run at Swarthmore and Delaware • Gillespie hits 37 points to lead Bears over Swarthmore in finale • Girl swimmers win over Penn and Elizabethtown • Junior varsity hoopmen finish with 11-6 record • Dickinson frat system defended • UC celebrates centennial with unique innovation • Forum features Howellhttps://digitalcommons.ursinus.edu/weekly/1171/thumbnail.jp