Probing Cosmic Dawn: Modelling the Assembly History, SEDs, and Dust Content of Selected z∼9z\sim9 Galaxies

The presence of spectroscopically confirmed Balmer breaks in galaxy spectral energy distributions (SEDs) at $z>9$ provides one of the best probes of the assembly history of the first generations of stars in our Universe. Recent observations of the gravitationally lensed source, MACS 1149_JD1 (JD1), indicate that significant amounts of star formation likely occurred at redshifts as high as $z\simeq15$. The inferred stellar mass, dust mass, and assembly history of JD1, or any other galaxy at these redshifts that exhibits a strong Balmer break, can provide a strong test of our best theoretical models from high-resolution cosmological simulations. In this work, we present the results from a cosmological radiation-hydrodynamics simulation of the region surrounding a massive Lyman-break galaxy. For two of our most massive systems, we show that dust preferentially resides in the vicinity of the young stars thereby increasing the strength of the measured Balmer break such that the simulated SEDs are consistent with the photometry of JD1 and two other $z>9$ systems (GN-z10-3 and GN-z9-1) that have proposed Balmer breaks at high redshift. We find strong variations in the shape and luminosity of the SEDs of galaxies with nearly identical stellar and halo masses, indicating the importance of morphology, assembly history, and dust distribution in making inferences on the properties of individual galaxies at high redshifts. Our results stress the importance that dust may play in modulating the observable properties of galaxies, even at the extreme redshifts of $z>9$.Comment: 16 pages, 13 Figures, Accepted to MNRA

The challenges of identifying Population III stars in the early Universe

The recent launch of JWST has enabled the exciting prospect of detecting the first generation of metal-free, Population III (Pop. III) stars. Determining characteristics that robustly signify Pop. III stars against other possible contaminants represents a key challenge. To this end, we run high-resolution (sub-pc) cosmological radiation hydrodynamics simulations of the region around a dwarf galaxy at z ≥ 10 to predict the emission line signatures of the Pop. III/Pop. II transition. We show that the absence of metal emission lines is a poor diagnostic of Pop. III stars because metal-enriched galaxies can maintain low [O iii] 5007 Å that may be undetectable due to sensitivity limits. Combining spectral hardness probes (e.g. He ii 1640 Å/H α) with metallicity diagnostics is more likely to probe metal-free stars, although contamination from Wolf-Rayet stars, X-ray binaries, or black holes may be important. The hard emission from Pop. III galaxies fades fast due to the short stellar lifetimes of massive stars, which could further inhibit detection. Pop. III stars may be identifiable after they evolve off the main sequence due to the cooling radiation from nebular gas or a supernova remnant; however, these signatures are also short-lived (i.e. few Myr). Contaminants including flickering black holes might confuse this diagnostic. While JWST will provide a unique opportunity to spectroscopically probe the nature of the earliest galaxies, both the short time-scales associated with pristine systems and ambiguities in interpreting emission lines may hinder progress. Special care will be needed before claiming the discovery of systems with pure Pop. III stars

Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development.

Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits. Our results suggested the occurrence of a metabolic change during citrus fruit maturation, where the organic acid and amino acid accumulation seen during the early stages of development shifted into sugar synthesis during the later stage of citrus fruit development. The expression of invertases remained unchanged, while an invertase inhibitor was up-regulated towards maturation. The increased expression of sucrose-phosphate synthase and sucrose-6-phosphate phosphatase and the rapid sugar accumulation suggest that sucrose is also being synthesized in citrus juice sac cells during the later stage of fruit development

Amitriptyline and scopolamine in an animal model of depression

Adult male Sprague-Dawley rats were subjected to acute (95 dB white noise) or chronic stress, or their combination. In comparison with unstressed controls, stressed rats were more active upon several measures of open field activity. A history of chronic stress eliminated the acute stress induced activation. Concurrent treatment of chronically stressed rats with amitriptyline or scopolamine, or with a combination of both drugs resulted in selective behavioral improvement (i.e., in motor activity, latency, defecation) for amitriptyline and combined treatment rats, with significant restoration of the normal behavioral response. Scopolamine however was only marginally effective. A higher dose of scopolamine proved effective, but only with a marked disruption of baseline activity. Examination of plasma corticosterone titers indicated that chronic stress induced an elevation of basal levels and that this was reversed by amitriptyline, scopolamine, and combined drug treatment. Thus while behavioral depression and elevated corticosteroids may covary they are not identically mediated.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24333/1/0000600.pd

Effects of Exenatide vs. Metformin on endothelial function in obese patients with pre-diabetes: a randomized trial

BACKGROUND: Glucagon like peptide-1 (GLP-1) receptor agonist treatment may improve endothelial function via direct and indirect mechanisms. We compared the acute and chronic effects of the GLP-1 receptor agonist exenatide vs. metformin on endothelial function in patients with obesity and pre-diabetes. METHODS: We performed a randomized, open-label, clinical trial in 50 non-diabetic individuals (mean age 58.5 ± 10.0; 38 females) with abdominal obesity and either impaired fasting glucose, elevated HbA1c, or impaired glucose tolerance (IGT) who were randomized to receive 3-months of exenatide or metformin. Microvascular endothelial function, assessed by digital reactive hyperemia (reactive hyperemic index: RHI), C-reactive protein (CRP), circulating oxidized LDL (oxLDL), and vascular cell adhesion molecule-1 (VCAM-1) were measured at baseline and 3-months. Seven subjects with IGT participated in a sub-study comparing the effects of pre-administration of exenatide and metformin on postprandial endothelial function. RESULTS: There were no differences for the change in RHI (Δ exenatide: 0.01 ± 0.68 vs. Δ metformin: -0.17 ± 0.72, P = 0.348), CRP, oxLDL, or VCAM-1 between exenatide and metformin treatment. Triglycerides were reduced more with exenatide compared to metformin (Δ exenatide: -25.5 ± 45.7 mg/dL vs. Δ metformin: -2.9 ± 22.8 mg/dL, P = 0.032). In the sub-study, there was no difference in postprandial RHI between exenatide and metformin. CONCLUSIONS: Three months of exenatide therapy had similar effects on microvascular endothelial function, markers of inflammation, oxidative stress, and vascular activation, as metformin, in patients with obesity and pre-diabetes. CLINICAL TRIALS REGISTRATION: This study is registered on http://www.clinicaltrials.gov/: NCT0054672

Long-lasting changes in morphine sensitivity following amygdaloid kindling in mice

Mice tested at either 3, 27 or 90 days following their last amygdala kindled convulsion exhibited a marked increase in response to morphine compared to controls. Kindled animals showed a higher incidence of clonic convulsions and an exaggerated Straub tail response, both of which could be blocked by naloxone pretreatment. The changes in response to morphine produced by kindling may provide a model for studying the long-lasting effects of convulsions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24190/1/0000449.pd