It\u27s All Happening at the Zoo: Children\u27s Environmental Learning after School

Pairing dynamic out-of-school-time (OST) programs with zoos can encourage young people\u27s relationships with and sense of responsibility for animals and the environment. The project presented in this article, Animal Rescuers, gave the authors the opportunity to examine how such a pairing can work. OST programs enable learning in settings that are generally unavailable during school time (Honig & McDonald, 2005). They provide space for collaboration among students, teachers, and others such as program visitors or outside educators. Taking advantage of the flexibility, location, and educational playfulness of an OST setting, the authors worked intensively with a small number of 10-12-year-old children to discover how they thought and felt about animals and to develop creative ways for them to share their knowledge and experiences with others. The children participated in zoo visits, environmental education activities, and an online space for expressing their feelings and working through their emerging ideas. Examining these activities and their effect on the children gives a better understanding of the educational role of zoos and of the kinds of OST activities that can influence children\u27s understanding of animals, extend their knowledge of conservation issues, and foster an ethic of care for the natural environment. While the primary focus of the project was to understand children\u27s environmental learning through a series of OST activities, the authors also looked at how zoos encourage their visitors to understand and care for animals at all scales, from the individual through the global. Despite extensive research on human-wildlife interactions, there is very little work that explores the connection of these interactions with questions of environmental and animal justice--and even less concerning their role in children\u27s development (see Hart & Chawla, 1981; Kellert, 2002; Watts, 2000; Wolch, 2002, for some notable exceptions). Their project addressed these questions with particular attention to the ways OST programs might foster children\u27s engagement with and attention to the natural environment

A Comment on BPS States in F-theory in 8 Dimensions

We study some aspects of enhanced gauge symmetries in F-theory compactified on K3. We find open string configurations connecting various 7-branes which represent stable BPS states. In this approach we recover $D_n$ and $E_n$ gauge groups previously found from an analysis of sigularities of the moduli space of elliptically fibered K3 manifolds as well as examples of non-perturbative realizations of $A_n$ groups.Comment: harvmac tex, 8 page

Quantum Wall Crossing in N=2 Gauge Theories

We study refined and motivic wall-crossing formulas in N=2 supersymmetric gauge theories with SU(2) gauge group and N_f < 4 matter hypermultiplets in the fundamental representation. Such gauge theories provide an excellent testing ground for the conjecture that "refined = motivic."Comment: 24 pages, 4 figure

L-functions with large analytic rank and abelian varieties with large algebraic rank over function fields

The goal of this paper is to explain how a simple but apparently new fact of linear algebra together with the cohomological interpretation of L-functions allows one to produce many examples of L-functions over function fields vanishing to high order at the center point of their functional equation. The main application is that for every prime p and every integer g>0 there are absolutely simple abelian varieties of dimension g over Fp(t) for which the BSD conjecture holds and which have arbitrarily large rank.Comment: To appear in Inventiones Mathematica

The BPS Spectrum of N=2 SU(N) SYM and Parton Branes

We apply ideas that have appeared in the study of D-branes on Calabi-Yau compactifications to the derivation of the BPS spectrum of field theories. In particular, we identify an orbifold point whose fractional branes can be thought of as ``partons'' of the BPS spectrum of N=2 pure SU(N) SYM. We derive the BPS spectrum and lines of marginal stability branes near that orbifold, and compare our results with the spectrum of the field theories.Comment: 29 pages, 4 figures, includes package diagrams.tex by Paul Taylo

Flavour from partially resolved singularities

In this letter we study topological open string field theory on D--branes in a IIB background given by non compact CY geometries ${\cal O}(n)\oplus{\cal O}(-2-n)$ on $\P1$ with a singular point at which an extra fiber sits. We wrap $N$ D5-branes on $\P1$ and $M$ effective D3-branes at singular points, which are actually D5--branes wrapped on a shrinking cycle. We calculate the holomorphic Chern-Simons partition function for the above models in a deformed complex structure and find that it reduces to multi--matrix models with flavour. These are the matrix models whose resolvents have been shown to satisfy the generalized Konishi anomaly equations with flavour. In the $n=0$ case, corresponding to a partial resolution of the $A_2$ singularity, the quantum superpotential in the ${\cal N}=1$ unitary SYM with one adjoint and $M$ fundamentals is obtained. The $n=1$ case is also studied and shown to give rise to two--matrix models which for a particular set of couplings can be exactly solved. We explicitly show how to solve such a class of models by a quantum equation of motion technique

A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection

The transduction of sound in the auditory periphery, the cochlea, is inhibited by efferent cholinergic neurons projecting from the brainstem and synapsing directly on mechanosensory hair cells. One fundamental question in auditory neuroscience is what role(s) this feedback plays in our ability to hear. In the present study, we have engineered a genetically modified mouse model in which the magnitude and duration of efferent cholinergic effects are increased, and we assess the consequences of this manipulation on cochlear function. We generated the Chrna9L9′T of knockin mice with a threonine for leucine change (L9′T) at position 9′ of the second transmembrane domain of the α9 nicotinic cholinergic subunit, rendering α9-containing receptors that were hypersensitive to acetylcholine and had slower desensitization kinetics. The Chrna9L9′T allele produced a 3-fold prolongation of efferent synaptic currents in vitro. In vivo, Chrna9L9′T mice had baseline elevation of cochlear thresholds and efferent-mediated inhibition of cochlear responses was dramatically enhanced and lengthened: both effects were reversed by strychnine blockade of the α9α10 hair cell nicotinic receptor. Importantly, relative to their wild-type littermates, Chrna9L9′T/L9′T mice showed less permanent hearing loss following exposure to intense noise. Thus, a point mutation designed to alter α9α10 receptor gating has provided an animal model in which not only is efferent inhibition more powerful, but also one in which sound-induced hearing loss can be restrained, indicating the ability of efferent feedback to ameliorate sound trauma.Fil: Taranda, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Tufts University School of Medicine; Estados UnidosFil: Maison, Stéphane F.. Massachusetts Eye and Ear Infirmary; Estados UnidosFil: Ballestero, Jimena Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Katz, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Savino, Jessica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Vetter, Douglas E.. Tufts University School of Medicine; Estados UnidosFil: Boulter, Jim. University of California at Los Angeles; Estados UnidosFil: Liberman, M. Charles. Massachusetts Eye and Ear Infirmary; Estados UnidosFil: Fuchs, Paul A.. The Johns Hopkins University School of Medicine; Estados UnidosFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentin

The "ART" of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa

BACKGROUND. Although loss to follow-up after antiretroviral therapy (ART) initiation is increasingly recognized, little is known about pre-treatment losses to care (PTLC) after an initial positive HIV test. Our objective was to determine PTLC in newly identified HIV-infected individuals in South Africa. METHODOLOGY/PRINCIPAL FINDINGS. We assembled the South African Test, Identify and Link (STIAL) Cohort of persons presenting for HIV testing at two sites offering HIV and CD4 count testing and HIV care in Durban, South Africa. We defined PTLC as failure to have a CD4 count within 8 weeks of HIV diagnosis. We performed multivariate analysis to identify factors associated with PTLC. From November 2006 to May 2007, of 712 persons who underwent HIV testing and received their test result, 454 (64%) were HIV-positive. Of those, 206 (45%) had PTLC. Infected patients were significantly more likely to have PTLC if they lived =10 kilometers from the testing center (RR=1.37; 95% CI: 1.11-1.71), had a history of tuberculosis treatment (RR=1.26; 95% CI: 1.00-1.58), or were referred for testing by a health care provider rather than self-referred (RR=1.61; 95% CI: 1.22-2.13). Patients with one, two or three of these risks for PTLC were 1.88, 2.50 and 3.84 times more likely to have PTLC compared to those with no risk factors. CONCLUSIONS/SIGNIFICANCE. Nearly half of HIV-infected persons at two high prevalence sites in Durban, South Africa, failed to have CD4 counts following HIV diagnosis. These high rates of pre-treatment loss to care highlight the urgent need to improve rates of linkage to HIV care after an initial positive HIV test.US National Institute of Allergy and Infectious Diseases (R01 AI058736, K24 AI062476, K23 AI068458); the Harvard University Center for AIDS Research (P30 AI42851); National Institutes of Health (K24 AR 02123); the Doris Duke Charitable Foundation (Clinical Scientist Development Award); the Harvard University Program on AID

Coisotropic D8-branes and Model-building

Up to now chiral type IIA vacua have been mostly based on intersecting D6-branes wrapping special Lagrangian 3-cycles on a CY three-fold. We argue that there are additional BPS D-branes which have so far been neglected, and which seem to have interesting model-building features. They are coisotropic D8-branes, in the sense of Kapustin and Orlov. The D8-branes wrap 5-dimensional submanifolds of the CY which are trivial in homology, but contain a worldvolume flux that induces D6-brane charge on them. This induced D6-brane charge not only renders the D8-brane BPS, but also creates D=4 chirality when two D8-branes intersect. We discuss in detail the case of a type IIA Z2 x Z2 orientifold, where we provide explicit examples of coisotropic D8-branes. We study the chiral spectrum, SUSY conditions, and effective field theory of different systems of D8-branes in this orientifold, and show how the magnetic fluxes generate a superpotential for untwisted Kahler moduli. Finally, using both D6-branes and coisotropic D8-branes we construct new examples of MSSM-like type IIA vacua.Comment: 63 pages, 11 figures. Typos corrected and comments adde

The spectrum of BPS branes on a noncompact Calabi-Yau

We begin the study of the spectrum of BPS branes and its variation on lines of marginal stability on O_P^2(-3), a Calabi-Yau ALE space asymptotic to C^3/Z_3. We show how to get the complete spectrum near the large volume limit and near the orbifold point, and find a striking similarity between the descriptions of holomorphic bundles and BPS branes in these two limits. We use these results to develop a general picture of the spectrum. We also suggest a generalization of some of the ideas to the quintic Calabi-Yau.Comment: harvmac, 45 pp. (v2: added references