In this letter we study topological open string field theory on D--branes in
a IIB background given by non compact CY geometries O(n)⊕O(−2−n) on ¶1 with a singular point at which an extra fiber sits. We wrap
N D5-branes on ¶1 and M effective D3-branes at singular points, which
are actually D5--branes wrapped on a shrinking cycle. We calculate the
holomorphic Chern-Simons partition function for the above models in a deformed
complex structure and find that it reduces to multi--matrix models with
flavour. These are the matrix models whose resolvents have been shown to
satisfy the generalized Konishi anomaly equations with flavour. In the n=0
case, corresponding to a partial resolution of the A2 singularity, the
quantum superpotential in the N=1 unitary SYM with one adjoint and M
fundamentals is obtained. The n=1 case is also studied and shown to give rise
to two--matrix models which for a particular set of couplings can be exactly
solved. We explicitly show how to solve such a class of models by a quantum
equation of motion technique