Stand-alone tsunami alarm equipment

One of the quickest means of tsunami evacuation is transfer to higher ground soon after strong and long ground shaking. Ground shaking itself is a good initiator of the evacuation from disastrous tsunami. Longer period seismic waves are considered to be more correlated with the earthquake magnitude. We investigated the possible application of this to tsunami hazard alarm using single-site ground motion observation. Information from the mass media is sometimes unavailable due to power failure soon after a large earthquake. Even when an official alarm is available, multiple information sources of tsunami alert would help people become aware of the coming risk of a tsunami. Thus, a device that indicates risk of a tsunami without requiring other data would be helpful to those who should evacuate. Since the sensitivity of a low-cost MEMS (microelectromechanical systems) accelerometer is sufficient for this purpose, tsunami alarm equipment for home use may be easily realized. Amplitude of long-period (20 s cutoff) displacement was proposed as the threshold for the alarm based on empirical relationships among magnitude, tsunami height, hypocentral distance, and peak ground displacement of seismic waves. Application of this method to recent major earthquakes indicated that such equipment could effectively alert people to the possibility of tsunami

Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus

Although co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective drug for prophylaxis against and treatment of Pneumocystis pneumonia, patients often experience adverse events with this combination, even at prophylactic doses. With the aim being to achieve individual optimization of co-trimoxazole therapy in patients with systemic lupus erythematosus (SLE), we investigated genetic polymorphisms in the NAT2 gene (which encodes the metabolizing enzyme of sulphamethoxazole). Of 166 patients with SLE, 54 patients who were hospitalized and who received prophylactic doses of co-trimoxazole were included in the cohort study. Adverse events occurred in 18 patients; only two experienced severe adverse events that lead to discontinuation of the drug. These two patients and three additional ones with severe adverse events (from other institutions) were added to form a cohort sample and were analyzed in a case-control study. Genotype was determined using TaqMan methods, and haplotype was inferred using the maximum-likelihood method. In the cohort study, adverse events occurred more frequently in those without the NAT2*4 haplotype (5/7 [71.4%]) than in those with at least one NAT2*4 haplotype (13/47 [27.7%]; P = 0.034; relative risk = 2.58, 95% confidence interval = 1.34–4.99). In the case-control study the proportion of patients without NAT2*4 was significantly higher among those with severe adverse events (3/5 [60%]) than those without severe adverse events (6/52 [11.5%]; P = 0.024; odds ratio = 11.5, 95% confidence interval = 1.59–73.39). We conclude that lack of NAT2*4 haplotype is associated with adverse events with co-trimoxazole in Japanese patients with SLE

Masovno ugušivanje riba u rijeci Treski i Vardaru

Micrococcal nuclease (MNase) has been widely used for analyses of nucleosome locations in many organisms. However, due to its sequence preference, the interpretations of the positions and occupancies of nucleosomes using MNase have remained controversial. Next-generation sequencing (NGS) has also been utilized for analyses of MNase-digests, but some technical biases are commonly present in the NGS experiments. Here, we established a gel-based method to map nucleosome positions in Saccharomyces cerevisiae, using isolated nuclei as the substrate for the histone H4 S47C-site-directed chemical cleavage in parallel with MNase digestion. The parallel mapping allowed us to compare the chemically and enzymatically cleaved sites by indirect end-labeling and primer extension mapping, and thus we could determine the nucleosome positions and the sizes of the nucleosome-free regions (or nucleosome-depleted regions) more accurately, as compared to nucleosome mapping by MNase alone. The analysis also revealed that the structural features of the nucleosomes flanked by the nucleosome-free region were different from those within regularly arrayed nucleosomes, showing that the structures and dynamics of individual nucleosomes strongly depend on their locations. Moreover, we demonstrated that the parallel mapping results were generally consistent with the previous genome-wide chemical mapping and MNase-Seq results. Thus, the gel-based parallel mapping will be useful for the analysis of a specific locus under various conditions

Liquefaction at Strong Motion Stations and in Urayasu City during the 2011 Tohoku-Oki Earthquake

The 2011 M[subscript W] = 9.0 Tohoku-oki earthquake generated a large number of unique soil liquefaction case histories, including cases with strong ground motion recordings on liquefiable or potentially liquefiable soils. We have compiled a list of 22 strong motion stations (SMS) where surface evidence of liquefaction was observed and 16 SMS underlain by geologically recent sediments or fills where surface evidence of liquefaction was not observed. Pre-earthquake standard penetration test data and borehole shear wave velocity (V[subscript s]) profiles are available for some stations, but critical information, such as grain size distribution and fines plasticity, are often lacking. In the heavily damaged city of Urayasu, we performed post-earthquake cone penetration testing at seven SMS and V[subscript s] profiles, using surface wave methods at 28 additional locations to supplement existing geotechnical data. We describe the liquefaction effects in Urayasu, the available site characterization data, and our initial data interpretations

Rapid magnitude determination from peak amplitudes at local stations

Artículo de publicación ISIThe rapid determination of its magnitude soon after a great earthquake is necessary for the issuing of effective tsunami warnings, as demonstrated in the great earthquake off Tohoku district in Japan on March 11, 2011. The earthquake magnitude for the first tsunami warning was underestimated due to magnitude saturation. This paper proposes a method to determine magnitude rapidly from peak velocity and displacement of long-period seismic waves up to 100 seconds at local stations. When waveform data at local stations are available, the magnitude from S-wave peaks is expected to be determined faster than that from only P-wave peaks. It takes about 140 seconds to estimate a magnitude of about 9 for the March 11, 2011, earthquake, which would enable us to issue the first tsunami warning within three minutes after the same type of earthquake