Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results

Purpose. To present our results after short-term (1 month) intra-arterial infusion therapy of PGE1-alprostadil via a port system implanted in the ipsilateral external iliac artery (EIA) in patients with severe rest pain. Methods. Ten patients with severe rest pain were included. All patients showed extensive peripheral vascular disease below the knee. The tip of the catheter was introduced via a retrograde puncture in the ipsilateral external iliac artery (EIA). The patients received intraarterial infusion of PGE1, 20 mgr alprostadil daily, via the port catheter for 1 month. Results. Clinical success was evaluated according to subjective grading of pain (group A significant decrease, group B moderate decrease and group C no response). A significant decrease of rest pain was observed in 8 (group A, 80%) patients, a moderate decrease in 2 (Group B, 20%), whereas no patients demonstrated any significant response. Both patients of group B had Buergers' disease and continue to smoke during therapy. No peripheral thrombosis or clinical deterioration was noticed. Conclusion. Intraarterial infusion of PGE1 alprostadil on a daily basis, using a port catheter into the ipsilateral EIA, in selected patients with severe rest pain, seems to be very effective, without any serious complications

Computational evaluation of metal pentazolate frameworks::Inorganic analogues of azolate metal-organic frameworks

We report a periodic density-functional theory evaluation of putative frameworks, including a topologically novel arhangelskite (arh) structure, based on the pentazolate ion, the ultimate all-nitrogen, inorganic member of the azolate series of aromatic 5-membered ring anions.</p

Fabrication of an Active Electronic Device Using a Hetero-bimetallic Coordination Polymer

A nickel(II)/lead(II) coordination polymer [(NCS)Pb(H2O)LNi(NCS)]n {H2L=N,N′-bis(3-methoxysalicylidene)propane-1,3-diamine} has been synthesized and characterized. The band gap (3.18 eV) calculated from Tauc’s plot suggests the semiconducting nature of the complex. The material has a photosensitivity of 5.76, indicating its applicability in the fabrication of photosensitive devices. The complex has been successfully applied in a technologically challenging thin-film photosensitive Schottky device

In situ monitoring and mechanism of the mechanochemical formation of a microporous MOF-74 framework

Mechanochemistry provides a rapid, efficient route to metal-organic framework Zn-MOF-74 directly from a metal oxide and without bulk solvent. In situ synchrotron X-ray diffraction monitoring of the reaction course reveals two new phases and an unusual step-wise process in which a close-packed intermediate reacts to form the open framework. The reaction can be performed on a gram scale to yield a highly porous material after activation

High-spin Ni(ii) clusters: triangles and planar tetranuclear complexes

The exploration of the NiX2/py(2)CO/Et3N ( X= F, Cl, Br, I; py(2)CO = di-2-pyridyl ketone; Et3N = triethylamine) reaction system led to the tetranuclear [Ni4Cl2py(2)C(OH)O(2)py(2)C(OMe)O(2)(MeOH)(2)]Cl-2 center dot 2Et(2)O (1 center dot 2Et(2)O) and [Ni4Br2py(2)C(OH)O(2)py(2)C(OMe)O(2)(MeOH)(2)]Br-2 center dot 2Et(2)O (2 center dot 2Et(2)O) and the trinuclear [Ni-3py(2)C(OMe)O(4)]I-2 center dot 2.5MeOH (3 center dot 2.6MeOH), [Ni-3py(2)C(OMe)O(4)](NO3)(0.65)I-1.35 center dot 2MeOH (4 center dot 2MeOH) and [Ni-3py(2)C(OMe)O(4)](SiF6)(0.8)F-0.4 center dot 3.5MeOH (5 center dot 3.5MeOH) aggregates. The presence of the intermediate size Cl- and Br- anions resulted in planar tetranuclear complexes with a dense hexagonal packing of cations and donor atoms (tetramolybdate topology) where the X-anions participate in the core acting as bridging ligands. The F- and I- anions do not favour the above arrangement resulting in triangular complexes with an isosceles topology. The magnetic properties of 1-3 have been studied by variable-temperature dc, variable-temperature and variable-field ac magnetic susceptibility techniques and magnetization measurements. All complexes are high-spin with ground states S = 4 for 1 and 2 and S = 3 for 3