282 research outputs found

    Being Social: Why the NCAA Has Forced Universities to Monitor Student-Athletes' Social Media

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    On June 21, 2011, the National Collegiate Athletic Association (NCAA) charged the University of North Carolina at Chapel Hill (UNC) with a number of NCAA legislation violations, including “not adequately and consistently monitor[ing] social networking activity that visibly illustrated potential amateurism violations within the football program[.]” While the NCAA’s bylaws regarding member institution conduct indirectly impacts social media oversight, the NCAA’s lack of a social media monitoring policy creates uncertainty as to how member institutions should deal with potential violations of a non-existing policy. Coupled with concerns about their public image, tort liability, and their student-athletes’ safety, NCAA member institutions must develop a social media monitoring policy that does not infringe on constitutional free speech rights or more specific social media privacy laws. Ultimately, monitoring publicly available social media might be the safest and the best way to protect the institutions’ interests without violating their student-athletes’ legal rights

    Regulation of Ov2 by virus encoded microRNAs

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    Diversification in Salmonella Typhimurium DT104

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    Ov2 is a modulator of OvHV-2 RTA mediated gene expression

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    Ascension

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    https://digitalcommons.georgiasouthern.edu/ascen/1000/thumbnail.jp

    Activity of ceftazidime/avibactam against problem Enterobacteriaceae and Pseudomonas aeruginosa in the UK, 2015-2016

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    Background: Ceftazidime/avibactam combines an established oxyimino-cephalosporin with the first diazabicyclooctane β-lactamase inhibitor to enter clinical use. We reviewed its activity against Gram-negative isolates, predominantly from the UK, referred for resistance investigation in the first year of routine testing, beginning in July 2015. Methods: Isolates were as received from referring laboratories; there is a bias to submit those with suspected carbapenem resistance. Identification was by MALDI-TOF mass spectroscopy, and susceptibility testing by BSAC agar dilution. Carbapenemase genes were sought by PCR; other resistance mechanisms were inferred using genetic data and interpretive reading. Results: Susceptibility rates to ceftazidime/avibactam exceeded 95% for: (i) Enterobacteriaceae with KPC, GES or other Class A carbapenemases; (ii) Enterobacteriaceae with OXA-48-like enzymes; and (iii) for ESBL or AmpC producers, even when these had impermeability-mediated ertapenem resistance. Almost all isolates with metallo-carbapenemases were resistant. Potentiation of ceftazidime by avibactam was seen for 87% of ceftazidime-resistant Enterobacteriaceae with ‘unassigned’ ceftazidime resistance mechanisms, including two widely referred groups of Klebsiella pneumoniae where no synergy was seen between cephalosporins and established β-lactamase inhibitors. Potentiation here may be a diazabicyclooctane/cephalosporin enhancer effect. Activity was seen against Pseudomonas aeruginosa with derepressed AmpC, but not for those with efflux-mediated resistance. Conclusions: Of the available β-lactams or inhibitor combinations, ceftazidime/avibactam has the widest activity spectrum against problem Enterobacteriaceae, covering all major types except metallo-carbapenemase producers; against P. aeruginosa it has a slightly narrower spectrum than ceftolozane/tazobactam, which also covers efflux-type resistance

    Clinical isolates of salmonella enterica serovar agona producing NDM-1 metallo-beta-lactamase: first report from Pakistan

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    We report two cases of infantile diarrhea due to multidrug-resistant, NDM-1 metallo-beta-lactamase-producing Salmonella enterica serovar Agona from Pakistan. This study alerts toward possible risk of NDM-1 transmission to enteric fever pathogens and encourages microbiologists to consider active screening of carbapenem resistance in nontyphoidal Salmonella isolates
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