3-Fluoro-N-(3-fluorobenzoyl)-N-(2-pyridyl)benzamide

The title compound, C19H12F2N2O2, a 2:1 product of the reaction of 3-fluorobenzoylchloride and 2-aminopyridine crystallizes with a disordered 3-fluorobenzene ring adopting two conformations [ratio of occupancies 0.959 (4):0.041 (4)]. In the crystal structure, there are no classical hydrogen bonds and interactions comprise C-H...O in the form 2(C-H)...O=C [with motif R21(5)]; C-H...[pi](arene) interactions are also present

Assembling an isomer grid: the isomorphous 4-, 3- and 2-fluoro-N'-(4-pyridyl)benzamides

The three title isomers, 4-, (I), 3-, (II), and 2-fluoro-N'-(4-pyridyl)benzamide, (III), all C₁₂H₉FN₂O, crystallize in the P21/c space group (No. 14) with similar unit-cell parameters and are isomorphous and isostructural at the primary hydrogen-bonding level. An intramolecular C-H...O=C interaction is present in all three isomers [C...O = 2.8681 (17)-2.884 (2) Å and C-H...O117-118°], with an additional N-H...F [N...F = 2.7544 (15) Å] interaction in (III). Intermolecular amide-pyridine N-H...N hydrogen bonds link molecules into one-dimensional zigzag chains [graph set C(6)] along the [010] direction as the primary hydrogen bond [N...N = 3.022 (2), 3.049 (2) and 3.0213 (17) Å]. These are augmented in (I) by C-H...π(arene) and cyclic C-F...π(arene) contacts about inversion centres, in (II) by C-F...F-C interactions [C...F = 3.037 (2) Å] and weaker C-H...π(arene)/C-H...F contacts, and in (III) by C-H...π(arene) and C=O...O=C interactions, linking the alternating chains into two-dimensional sheets. Typical amide N-H...O=C hydrogen bonds [as C(4) chains] are not present [N...O = 3.438 (2) Å in (I), 3.562 (2) Å in (II) and 3.7854 (16) Å in (III)]; the C=O group is effectively shielded and only participates in weaker interactions/contacts. This series is unusual as the three isomers are isomorphous (having similar unit-cell parameters, packing and alignment), but they differ in their interactions and contacts at the secondary level

Addressing the Lesbian, Gay, Bisexual and Transgender Cultural Competency Gap in Genetic Counseling: A Curriculum Pilot Study

Previous studies have reported that 90.1% of genetic counselors know they have counseled a patient who identifies as Lesbian, Gay, Bisexual or Transgender (LGBT). Since unique health disparities exist within the LGBT population, studies have found significant benefit to LGBT patient care curriculum in medical training programs. Of genetic counselors surveyed in past studies, few (17%) had received LGBT specific training and most (61%) desired such training. This information suggests a need for LGBT topics to be implemented into the education of genetic counselors. This study tests this hypothesis by development, implementation and assessment of a replicable LGBT curriculum that was observed by 21 students currently enrolled in a genetic counseling training program. The curriculum was developed by review of literature regarding present LGBT issues in health care and genetic counseling, as well as methods of teaching cultural competency. The curriculum was assessed using participant completion of the adapted Sexual Orientation Counselor Competency Scale (SOCCS) pre- and post-curriculum observation. The SOCCS allowed for assessment of the change in sexual orientation competency of genetic counseling students in the areas of knowledge, attitudes and skills due to this curriculum. Additionally, a Knowledge-Based Survey specific to genetic counseling was used to further assess the benefits. The curriculum developed as a result of this study was shown to improve participants’ total sexual orientation competency, knowledge and skills on providing genetic counseling to the LGBT population. Students reported that they believed the curriculum would serve as a useful reference in their careers and were, on average, overall satisfied with the content and presentation of content. Additional findings and methods for implementation and adaptation for use in future genetic counseling trainings are presented

Scattering theory for the Schr\"odinger-Debye System

We study the Schr\"odinger-Debye system over $\mathbb{R}^d$ iu_t+\frac 12\Delta u=uv,\quad \mu v_t+v=\lambda |u|^2 and establish the global existence and scattering of small solutions for initial data in several function spaces in dimensions $d=2,3,4$. Moreover, in dimension $d=1$, we prove a Hayashi-Naumkin modified scattering result.Comment: 22 page

The perceptions of neonatal nurses' towards extremely preterm infants

Technological advances in neonatal care have meant that the survival rates of preterm infants have dramatically increased. Improvements in mortality have not been reflected in improvements in morbidity, however, and the chances of extremely preterm infants surviving free from serious morbidity remain low. Concerns regarding mortality and morbidity rates have resulted in a plethora of ethical debates surrounding extremely preterm infants. The application and cost of advancing technology has been questioned. The impact that the risk of severe disability should have on decision making, along with who should make these decisions, the parents or the health care professionals, remains under debate. The influence that advancing fertility treatment has on decision making has yet to be explored, despite causing controversy in the media. Improving mortality rates have also prompted a proposal to reduce the current abortion limits in the United Kingdom. Despite a wealth of research into these ethical dilemmas, the voices of neonatal nurses towards these debates surrounding the infants which they care for have remained silent. The aim of this study is to therefore explore the perceptions of neonatal nurses towards extremely preterm infants. Q methodology was used to explore the attitudes of 36 nurses working in a perinatal network in the United Kingdom. Nurses 'sorted' a set of 53 statements developed from literature and previous research which represented the debates surrounding extremely preterm infants. Nurses then participated in a 'post Q sort' interview to explore the rationale behind their placement of the statements. The findings indicated that there were three types of nursing perceptions towards extremely preterm infants, centred on the involvement of parents in making difficult decisions. Some nurses reported their belief in accounting for parental choice is making difficult decisions. For others, they discussed their beliefs that the health care professional should undertake difficult decisions. The remaining nurses reported a belief in technology over and above decision making, suggesting that technology would prevail and allow more preterm infants to survive. The findings reflected the complex neonatal environment where core 'learnt' nursing values were often difficult to implement. Highlighting the perceptions of neonatal nurses' towards extremely preterm infants allowed for an in-depth exploration of the rationale behind these patterns of perceptions. Conclusions were drawn from this regarding how to improve the engagement of not only neonatal nurses, but the parents also, in the infant's care. A palliative care policy is suggested from these findings in order to help nurses make the transition from curative to palliative care. The conceptual framework developed for the study was adjusted accordingly, and future clinical and research recommendations made

Neonatal nursing led research activity in the UK: a survey of current practice

© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Abstract: Background: Neonatal nurses are ideally placed in practice to undertake research enhancing the care of families. More information is required, however, around neonatal nursing led research to advance leadership in this area. The aim of this study was to determine neonatal nursing led research activity within the UK. Methods: The study used a web-based survey design and neonatal nurses were eligible if they were working at or towards Masters or Doctoral level qualification in the UK. The survey was distributed to members of the Neonatal Nurses Association, UK Schools of Nursing and shared on social media pages of authors and professional organisations. Results were analysed using descriptive and frequency statistics and content analysis. Results: Of the 56 respondents, 14% (n = 8) had a Doctoral level qualification and 43% (n = 24) of participants held a Masters qualification. Lack of time and funding knowledge was the largest barrier to research. Only 30% (n = 3) of participants had a research mentor and only 18% (n = 3) were from a neonatal nursing background. Conclusions: There are limited numbers of neonatal nurses undertaking or leading nursing research in the UK. Further support is required to enhance clinical academic career trajectories to ensure research is a viable pathway for future generations of neonatal nurses.Peer reviewedFinal Published versio

Parental experiences of live video streaming technology in neonatal care in England: a qualitative study

BACKGROUND: The use of bedside cameras in neonatal units facilitates livestreaming of infants to support parental and family bonding when they are unable to be physically present with their baby. This study aimed to explore the experiences of parents of infants previously admitted for neonatal care and who used live video streaming to view their baby in real-time. METHODS: Qualitative semi-structured interviews were conducted after discharge with parents of infants admitted for neonatal care on a tertiary level neonatal unit in the UK in 2021. Interviews were conducted virtually, transcribed verbatim and uploaded into NVivo V12 to facilitate analysis. Thematic analysis by two independent researchers was undertaken to identify themes representing the data. RESULTS: Seventeen participants took part in sixteen interviews. Thematic analysis identified 8 basic themes which were grouped into 3 organizational themes: (1) family integration of the baby including parent-infant, sibling-infant, and wider family-infant attachment facilitated through livestreaming, (2) implementation of the livestreaming service including communication, initial set up of the livestreaming service, and areas for improvement, and (3) parental control including emotional, and situational control. CONCLUSIONS: The use of livestreaming technology can provide parents with opportunities to integrate their baby into their wider family and friendship community and gain a sense of control over their baby's admission for neonatal care. On-going parental education around how to use, and what to expect from, livestreaming technology is required to minimise any potential distress from viewing their baby online

2-Fluoro-N-(2-fluoro­benzo­yl)-N-(2-pyrid­yl)benzamide

The title compound, C19H12F2N2O2, a 2:1 product of the reaction of 2-fluoro­benzoyl chloride and 2-amino­pyridine, crystallizes with a disordered 2-fluoro­benzene ring adopting two conformations [ratio of occupancies = 0.930 (4):0.070 (4)] in one of the two independent mol­ecules (differing slightly in conformation) comprising the asymmetric unit. In the crystal structure, C—H⋯O and C—H⋯π(arene) inter­actions are present

3-Fluoro-N-(3-fluoro­benzo­yl)-N-(2-pyrid­yl)benzamide

The title compound, C19H12F2N2O2, a 2:1 product of the reaction of 3-fluoro­benzoyl­chloride and 2-amino­pyridine crystallizes with a disordered 3-fluoro­benzene ring adopting two conformations [ratio of occupancies 0.959 (4):0.041 (4)]. In the crystal structure, there are no classical hydrogen bonds and inter­actions comprise C—H⋯O in the form 2(C—H)⋯O=C [with motif R 2 1(5)]; C—H⋯π(arene) inter­actions are also present