Comparison of <i>Full_Bsif</i> and the ensemble <i>F</i> of the best methods investigate in this section (<i>AUC</i> is reported).

<p>Comparison of <i>Full_Bsif</i> and the ensemble <i>F</i> of the best methods investigate in this section (<i>AUC</i> is reported).</p

Preprocessing by <i>Wa</i>.

<p>Rows represent the three classes fusiform, epithelioid and cobblestone. <i>Left</i>: original image; <i>right</i>: horizontal, vertical and diagonal details.</p

Class properties used for building the ground truth.

<p>Class properties used for building the ground truth.</p

Preprocessing by <i>OR</i>.

<p>Rows represent the three classes fusiform, epithelioid and cobblestone. <i>Left</i>: original image; <i>right</i>: the three oriented images.</p

Flowchart of the quinary coding and usage of the geometric <i>loci</i>.

<p>Flowchart of the quinary coding and usage of the geometric <i>loci</i>.</p

Texture descriptors and their parameter sets.

<p>Texture descriptors and their parameter sets.</p

Fittings of the model to the experimental data.

<p>(A) GA-treated, and (B) control data sets with dashed lines representing the data in dimensionless NF units and solid lines representing the model simulations with arbitrary units representing [Ca^<b>2+</b>]_i in μM concentrations. The uppermost curve pair (blue) represents NB1, the second uppermost NB2 (green), followed by NB3 (red), NB4 (light blue), NB5 (purple), NB6 (yellow), NB7 (black), NB8 (light red), NB9 (grey), and NB10 (orange).</p

Collagen-immobilized polyimide membranes for retinal pigment epithelial cell adherence and proliferation

Degenerative retinal diseases are a leading cause of visual loss and irreversible blindness, particularly in the developed world. Retinal pigment cell (RPE) transplantation is nowadays considered the most promising therapeutic approach for certain retinal diseases, and the presence of a supportive scaffold has been considered essential to ensure the success of the implant. In this work, collagen IV was covalently immobilized to the surface of polyimide membranes, with the purpose of developing scaffold materials for RPE cell culture. The covalent modification method involved four steps: argon-plasma treatment, acrylic acid graft polymerization, surface activation, and finally immobilization of collagen type IV. Collagen-modified membranes did not become more rough but became significantly more hydrophilic than the unmodified and dip-coated controls. ARPE-19 cell morphology and attachment were studied by immunofluorescence staining and confocal microscopy. Covalently modified surfaces showed cell attachment and cell properties comparable to the uncoated and dip-coated controls. This work demonstrated the potential of collagen IV-immobilized polyimide membranes as substrates for the growth of ARPE-19 cells.publishedVersionPeer reviewe

Illustrative images of the RPE maturation stages (classes).

<p>From <i>left</i> to <i>right</i>: fusiform, epithelioid, cobblestone and mixed (Fusiform and Epithelioid).</p

Performance (<i>AUC</i>) obtained coupling the best texture descriptors with different preprocessing methods.

<p>Performance (<i>AUC</i>) obtained coupling the best texture descriptors with different preprocessing methods.</p