9 research outputs found

    Underpinning Sustainable Vector Control through Informed Insecticide Resistance Management

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    Background: There has been rapid scale-up of malaria vector control in the last ten years. Both of the primary control strategies, long-lasting pyrethroid treated nets and indoor residual spraying, rely on the use of a limited number of insecticides. Insecticide resistance, as measured by bioassay, has rapidly increased in prevalence and has come to the forefront as an issue that needs to be addressed to maintain the sustainability of malaria control and the drive to elimination. Zambia’s programme reported high levels of resistance to the insecticides it used in 2010, and, as a result, increased its investment in resistance monitoring to support informed resistance management decisions. Methodology/Principal Findings: A country-wide survey on insecticide resistance in Zambian malaria vectors was performed using WHO bioassays to detect resistant phenotypes. Molecular techniques were used to detect target-site mutations and microarray to detect metabolic resistance mechanisms. Anopheles gambiae s.s. was resistant to pyrethroids,DDT and carbamates, with potential organophosphate resistance in one population. The resistant phenotypes were conferred by both target-site and metabolic mechanisms. Anopheles funestus s.s. was largely resistant to pyrethroids and carbamates, with potential resistance to DDT in two locations. The resistant phenotypes were conferred by elevated levels of cytochrome p450s. Conclusions/Significance: Currently, the Zambia National Malaria Control Centre is using these results to inform their vector control strategy. The methods employed here can serve as a template to all malaria-endemic countries striving to create a sustainable insecticide resistance management pla

    Spatiotemporal pattern of insecticide use for IRS in Zambia from 2005–2012.

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    <p>Each dot represents the insecticide history for a single district or cluster of districts with similar history (Copperbelt Province). The earliest insecticide used is indicated in the centre of each dot. Subsequent insecticides are added as layers, with the thickness of the layer representing how many years the insecticide was used. Different colours represent different insecticide classes. The size of the dot indicates how many years IRS has been active. Hashed areas indicate times and locations where DDT and pyrethroids were used concurrently, with the former on mud homes and the latter on painted surfaces.</p
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