Additional file 1: of Multiple imputation for handling missing outcome data when estimating the relative risk

Web Appendix. (DOCX 227 kb

Русская революцiя : (ея начало, арестъ Царя, перспективы) : впечатлѣнiя и мысли очевидца и участника / А. А. Бубликов

Procedure for performing a simulation study for a normally distributed outcome. (DOCX 31 kb

Additional file 11: Figure S8. of Evaluation of a weighting approach for performing sensitivity analysis after multiple imputation

Graphical diagnostics for a single simulated dataset (n = 1000, m = 500, δ(True) = 0.2, μ(True) = 0, μ ^ ( S i m u l a t e ) $${\widehat{\boldsymbol{\mu}}}_{\left(\boldsymbol{Simulate}\right)}$$ = − 0.009). (DOCX 2362 kb

Additional file 2: Figure S2. of Evaluation of a weighting approach for performing sensitivity analysis after multiple imputation

Procedure for performing a simulation study for a binary outcome variable. (DOCX 31 kb

Additional file 4: Table S1. of Evaluation of a weighting approach for performing sensitivity analysis after multiple imputation

Estimates of the marginal mean of the normally distributed outcome variable and the regression coefficient under four analysis methods for a single simulated dataset (n = 500, m = 300, δ = 1). (DOCX 18 kb

Additional file 1: of A comparison of multiple imputation methods for handling missing values in longitudinal data in the presence of a time-varying covariate with a non-linear association with time: a simulation study

Supplementary Material. (DOCX 550 kb

Influence of Activated Charcoal on Desorption Kinetics and Biodegradation of Phenanthrene in Soil

The observed strong sorption of polycyclic aromatic hydrocarbons (PAHs) to black carbon (BC) presents potential implications for PAH bioaccessibility in soils. The effects of BC on the desorption kinetics and mineralization of phenanthrene in four soils was investigated after 1, 25, 50, and 100 d soil–PAH contact time, using sequential hydroxypropyl-β-cyclodextrin (HPCD) extractions in soils amended with 0, 0.1, 1, and 5% (dry wt. soil) activated charcoal (AC, a form of BC). The rapidly (%<i>F</i>_rap) and slowly (%<i>F</i>_slow) desorbing phenanthrene fractions and their rate constants were determined using a first-order two-compartment (biphasic) desorption model. A minimum 7.8-fold decrease in %<i>F</i>_rap occurred when AC was increased from 0 to 5%, with a corresponding increase in %<i>F</i>_slow. Desorption rate constants followed the progression <i>k</i>_rap (% h^–1) > <i>k</i>_slow (% h^–1) and were in the order of 10^–1 to 10^–2 and 10^–3 to 10^–4, respectively. Linear regressions between %<i>F</i>_rap and the fractions degraded by a phenanthrene-degrading inoculum (%<i>F</i>_min) indicated that slopes did not approximate 1 at concentrations greater than 0% AC; %<i>F</i>_min often exceeded %<i>F</i>_rap, indicating a fraction of sorbed phenanthrene (%<i>F</i>_slow) remained microbially accessible. Therefore, HPCD-desorption kinetics alone may not be an adequate basis for the prediction of the bioaccessibility of PAHs to microorganisms or bioremediation potential in AC-amended soils

Guselkumab for the Treatment of Psoriasis: A Review of Phase III Trials

<p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s13555-017-0187-0">https://link.springer.com/article/10.1007/s13555-017-0187-0</a></p><p></p> <p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p

Additional file 1: of Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age

Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age. Supplemental files: Research questions. Copy of research questions used in study. (DOCX 53 kb

L-Wnt3a stimulates the survival, proliferation, and engraftment of bone marrow cells.

<p>(A) Aged BMT were treated with L-PBS or (B) L-Wnt3a with an effective concentration = 150 ng/ml, then transplanted into a skeletal defect and after 12 h, analyzed for DNA fragmentation associated with cell apoptosis using TUNEL. (C) Quantification of caspase activity in aged BM treated with L-PBS (grey bar; N = 4) or L-Wnt3a (blue bar; N = 4). (D) Quantification of Ki67 immunostaining for aged BM treated with (E) L-PBS or (F) L-Wnt3a, then transplanted into a skeletal defect and after 12 h analyzed for cell proliferation. (G) FACS analyses of L-PBS treated BMT, harvested from the defect site on post-transplant day 5. (H) FACS analyses of L-Wnt3a treated BMT, harvested from the defect site on post-transplant day 5. (I) GFP immunostaining identifies the L-PBS treated BMT on post-transplant day 7 (J) GFP immunostaining identifies the L-Wnt3a treated BMT on post-transplant day 7. (K) GFP immunostaining shown in higher magnification demonstrating L-PBS treated BMT on post-transplant day 7 (L) GFP immunostaining shown in higher magnification demonstrating L-Wnt3a treated BMT on post-transplant day 7 (M) Histomorphometric quantification of GFP immunopositive cells in the defect site on post-transplant day 7 (N = 5 for each condition). Abbreviations: GFP: green fluorescent protein; TUNEL: Terminal deoxynucleotidyl transferase dUTP nick end labeling; Scale bars: A,B: 50 µm E,F: 100 µm; I,J: 200 µm; K,L: 50 µm.</p