Smart economics: evaluation of Australian aid support for women’s economic empowerment

This report evaluates how effective Australia has been in achieving gender equality outcomes in economic development programs. Executive summary Promoting women’s economic empowerment is ‘smart economics’. When women are fully involved in economic development, countries become more equitable and prosperous. Worldwide, there has been steady progress for women and girls in the key sectors of health and education. However, Australia—like most donors—has had limited success in achieving gender equality outcomes in economic development programs. Last financial year, approximately 25 per cent of the Australian aid budget was invested in the economic sectors, ranging from primary industry through to the production of goods and provision of services. Australian aid support for economic development is mainly concentrated on agriculture, rural development and transport. Smaller, but still significant, amounts of aid focus on energy, trade, and business and banking. Less than a third of this economic sector investment can demonstrate an explicit focus on gender equality. This is a concern, especially given Australia’s longstanding policy of ‘mainstreaming’ gender equality in its aid program

Alcohol Availability, Marketing, and Sexual Health Risk Amongst Urban and Rural Youth in South Africa.

South Africa has high rates of HIV prevalence and incidence and very high binge drinking rates amongst youth. GIS mapping of alcohol outlets and participatory research methods were used to explore and understand youth's perception of alcohol availability and marketing, and their associated risks for HIV and sexual violence. Twenty seven youth 18-24 years from an urban and rural area participated in the study. There was high density of alcohol outlets at both sites with 97% within 500 m radius to a school; 76% of outlets had alcohol advertising signage on the exterior. Youth reported that alcohol is easily accessible to them. Alcohol advertising and marketing are appealing and entice them to consume alcohol, including binge drinking. Young women reported exposure to unsafe and transactional sex, and sexual violence at alcohol outlets. Effective policies are needed to regulate alcohol availability and marketing to youth

Normalizing Alcohol Consumption among Youth: Role of Peers, Media, and Access to Alcohol in Mumbai

Background: Evidence suggests a link between alcohol marketing, advertisements, and underage drinking. Despite India having prohibitive alcohol policies including a ban on advertising, there has been an increase in underage drinking. Purpose: We explore young peoples’ experiences of alcohol in Mumbai and their drinking behavior. We also explore how young underage people are exposed to alcohol marketing and advertisements and how they access alcohol. Methods. We conducted a descriptive mixed methods study using Geographical Information System (GIS) mapping and participatory action research method called photo voice. Seven young people aged 18-24 participated in photo voice. Participants took photographs of their experiences of alcohol. The photographs informed the discussion at the photo voice workshops. We used GIS to map the proximity of alcohol outlets to educational institutions in Mumbai. Results: We found several interconnected factors that explain how young people perceive alcohol and how these factors contribute to the ‘normalization’ of alcohol. These include family influence, peer and media influence, gender norms, and access to alcohol. Despite being below the legal drinking age in the state, participants reported drinking underage. Using GIS we found that alcohol was available and accessible in proximity of colleges. Conclusion: This study highlights that despite restrictive alcohol policies, young people are exposed to alcohol marketing in multiple ways and is accessible and available to them. The consumption of alcohol is socially normalized and sanctioned through media, family and peer influences. It is necessary to reconsider current alcohol policies in India and design programs that address underage drinking

Use of Denosumab in Children With Osteoclast Bone Dysplasias: Report of Three Cases.

Denosumab has been used successfully to treat disease-associated osteoclast overactivity, including giant cell tumor of bone. Given its mechanism of action, denosumab is a potent potential treatment of other osteoclast bone dysplasias including central giant cell granuloma (CGCG), aneurysmal bone cyst (ABC), and cherubism. Relatively little is known about the safety and efficacy of denosumab in patients with these conditions, especially in children. We report on 3 pediatric patients treated with denosumab over a 3-year period at UCLA Medical Center (Los Angeles and Santa Monica, CA, USA): a 12-year-old with recurrent ABC of the pelvis, a 14-year-old with CGCG of the mandible, and a 12-year-old with cherubism. All were started on a 1-year course of 15 doses 120 mg s.c., given monthly with two loading doses on day 8 and 15. All patients demonstrated rapid and pronounced clinical improvement while on denosumab, including a significant reduction in pain and sclerosis of lytic lesions on radiographs. Within 1 month of initiating therapy, 2 patients experienced hypocalcemia (Common Terminology Criteria for Adverse Events [CTCAE] grade 2) and hypophosphatemia, with 1 patient experiencing symptoms. One patient went on to experience symptomatic rebound hypercalcemia (CTCAE grade 4) 5 months after completing therapy, requiring bisphosphonates and calcitonin. For the second patient, we developed a schedule to wean denosumab involving the progressive lengthening of time between doses from 1 to 4 months in 1-month increments before cessation. We found that denosumab therapy results in significant clinical and radiographic improvement for pediatric patients with nonresectable ABC, CGCG, and cherubism. Problems with serum calcium may be more common in younger patients, with symptomatic and protracted rebound hypercalcemia after cessation of therapy the most significant. We present a potential solution to this problem with progressive spacing of doses. Potential serious adverse events from alterations in calcium homeostasis should be explored in prospective clinical trials. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research

Simulation of Man in the Middle Attack On Smart Grid Testbed

Over the past decade, the frequency of cyber attacks against power grids has steadily increased, requiring researchers to find and patch vulnerabilities before they can be exploited. Our research introduces the prototype of a man-in-the-middle attack to be implemented on a microgrid emulator of a smart grid. We present a method of violating the integrity and authentication of packets that are using the IEEE Synchrophasor Protocol in a controlled environment, but this same approach could be used on any other protocol that lacks the proper overhead to ensure the integrity and authenticity of packets. In future research, we plan to implement and test the attack on the previously mentioned smart grid testbed in order to assess the attacks feasibility and tangible effects on Wide Area Monitoring and Control applications, as well as propose possible countermeasures. For this paper, we developed a working simulation of our intended attack using the software ModelSim 10.4. The attack will modify network packet data coming from a Schweitzer Engineering Labs (SEL) Phasor Measurement Unit (PMU) hardware sensor, which provides a stream of precise timing values associated with current and voltage values, as these measured values are en route to the Open Phasor Data Concentrator (OpenPDC) application running on a Windows server. Our simulation provides and validates all of the necessary code in order to program a Field Programmable Gate Array and execute our attack on the testbed in future research

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells

Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New York, NY). Because the toxicity of these materials is mediated by oxidative stress, it seemed possible that the protective effects of IGF-1 and TGF-β were through the enhancement of an endogenous antioxidant mechanism. Methods We used cultured dental pulp cells to determine the mechanism of the protective effects of IGF-1 and TGF-β, focusing on the glutathione system and the role of cystine/glutamate exchange (system xc-). Results We found that the toxicity of Durafill VS and Flow Line was attenuated by the addition of glutathione monoethylester, suggesting a specific role for the cellular antioxidant glutathione. Supporting this hypothesis, we found that IGF-1 and TGF-β were protective against the toxicity of the glutathione synthesis inhibitor buthionine sulfoximine. Because levels of cellular cystine are the limiting factor in the production of glutathione, we tested the effects of IGF-1 and TGF-β on cystine uptake. Both growth factors stimulated system xc–mediated cystine uptake. Furthermore, they attenuated the glutathione depletion induced by Durafill VS and Flow Line. Conclusions The results suggest that IGF-1 and TGF-β are protective through the stimulation of system xc–mediated cystine uptake, leading to maintenance of cellular glutathione. This novel action of growth factors on dental pulp cells has implications not only for preventing toxicity of dental materials but also for the general function of these cells

Power and the association with relationship quality in South African couples: Implications for HIV/AIDS interventions.

Introduction: power imbalances within sexual relationships have significant implications for HIV prevention in sub-Saharan Africa. Little is known about how power influences the quality of a relationship, which could be an important pathway leading to healthy behavior around HIV/AIDS.Methods: this paper uses data from 448 heterosexual couples (896 individuals) in rural KwaZulu-Natal, South Africa who completed baseline surveys from 2012 to 2014 as part of a couples-based HIV intervention trial. Using an actor-partner interdependence perspective, we assessed: (1) how both partners' perceptions of power influences their own (i.e., actor effect) and their partner's reports of relationship quality (i.e., partner effect); and (2) whether these associations differed by gender. We examined three constructs related to power (female power, male equitable gender norms, and shared power) and four domains of relationship quality (intimacy, trust, mutually constructive communication, and conflict).Results: for actor effects, shared power was strongly and consistently associated with higher relationship quality across all four domains. The effect of shared power on trust, mutually constructive communication, and conflict were stronger for men than women. The findings for female power and male equitable gender norms were more mixed. Female power was positively associated with women's reports of trust and mutually constructive communication, but negatively associated with intimacy. Male equitable gender norms were positively associated with men's reports of mutually constructive communication. For partner effects, male equitable gender norms were positively associated with women's reports of intimacy and negatively associated with women's reports of conflict.Conclusions: research and health interventions aiming to improving HIV-related behaviors should consider sources of shared power within couples and potential leverage points for empowerment at the couple level. Efforts solely focused on empowering women should also take the dyadic environment and men's perspectives into account to ensure positive relationship outcome

Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer.

Background:Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors influencing this risk are unknown. We aimed to determine whether high intratumor heterogeneity of ER predicts an increased long-term risk (25 years) of fatal breast cancer. Methods:The STO-3 trial enrolled 1780 postmenopausal lymph node-negative breast cancer patients randomly assigned to receive adjuvant tamoxifen vs not. The fraction of cancer cells for each ER intensity level was scored by breast cancer pathologists, and intratumor heterogeneity of ER was calculated using Rao's quadratic entropy and categorized into high and low heterogeneity using a predefined cutoff at the second tertile (67%). Long-term breast cancer-specific survival analyses by intra-tumor heterogeneity of ER were performed using Kaplan-Meier and multivariable Cox proportional hazard modeling adjusting for patient and tumor characteristics. Results:A statistically significant difference in long-term survival by high vs low intratumor heterogeneity of ER was seen for all ER-positive patients (P < .001) and for patients with luminal A subtype tumors (P = .01). In multivariable analyses, patients with high intratumor heterogeneity of ER had a twofold increased long-term risk as compared with patients with low intratumor heterogeneity (ER-positive: hazard ratio [HR] = 1.98, 95% confidence interval [CI] = 1.31 to 3.00; luminal A subtype tumors: HR = 2.43, 95% CI = 1.18 to 4.99). Conclusions:Patients with high intratumor heterogeneity of ER had an increased long-term risk of fatal breast cancer. Interestingly, a similar long-term risk increase was seen in patients with luminal A subtype tumors. Our findings suggest that intratumor heterogeneity of ER is an independent long-term prognosticator with potential to change clinical management, especially for patients with luminal A tumors

Using Participatory Mapping to Inform a Community-Randomized Trial of HIV Counseling and Testing

Participatory mapping and transect walks were used to inform the research and intervention design and to begin building community relations in preparation for Project Accept, a community-randomized trial sponsored by the U.S. National Institute of Mental Health (NIMH). NIMH Project Accept is being conducted in five sites within four countries including Thailand, Zimbabwe, South Africa and Tanzania. Results from the mapping exercises informed decisions about the research design such as defining community boundaries, and identifying appropriate criteria for matching community pairs for the trial. The mapping also informed intervention related decisions such as where to situate the services. The participatory methods enabled each site to develop an understanding of the communities that could not have been derived from existing data or data collected through standard data collection techniques. Furthermore, the methods lay the foundation for collaborative community research partnerships