Future Type Ia Supernova Data as Tests of Dark Energy from Modified Friedmann Equations

In the Cardassian model, dark energy density arises from modifications to the Friedmann equation, which becomes H^2 = g(\rhom), where g(\rhom) is a new function of the energy density. The universe is flat, matter dominated, and accelerating. The distance redshift relation predictions of generalized Cardassian models can be very different from generic quintessence models, and can be differentiated with data from upcoming pencil beam surveys of Type Ia Supernovae such as SNAP. We have found the interesting result that, once $\Omega_m$ is known to 10% accuracy, SNAP will be able to determine the sign of the time dependence of the dark energy density. Knowledge of this sign (which is related to the weak energy condition) will provide a first discrimination between various cosmological models that fit the current observational data (cosmological constant, quintessence, Cardassian expansion). Further, we have performed Monte Carlo simulations to illustrate how well one can reproduce the form of the dark energy density with SNAP. To be concrete we study a class of two parameter ($n$,$q$) generalized Cardassian models that includes the original Cardassian model (parametrized by $n$ only) as a special case. Examples are given of MP Cardassian models that fit current supernovae and CMB data, and prospects for differentiating between MP Cardassian and other models in future data are discussed. We also note that some Cardassian models can satisfy the weak energy condition $w>-1$ even with a dark energy component that has an effective equation of state $w_X < -1$.Comment: revised version accepted by Ap

Training Habits of Non-Elite Marathon Runners

Marathon running has become an increasing trend in the United States among non-elite marathon runners. Distance training is a demanding and physical task and a runner needs the proper training program to meet the demand of distance running. Non-elite runners typically lack formal running training and may not realize the damage they could cause to their body with improper running techniques through long distance training. With the increase in non-elite runners, it is probable that there will be an increase in these runners seeking advice from personal trainers or running coaches. Using research on how successful runners are training for performance, coaches and trainers may better prepare their clients for distance training, races and recovery. The purpose of this study was to examine the training methods of non-elite marathon runners. One hundred and fifteen participants, 58 male and 57 female (age 37.20 � 12.34) completed the web-based survey. Questions regarding their run training practices, training surface, cross-training and if they worked with a running coach or personal trainer were assessed. Results of the survey determined that males ran faster (P= .000) and ran more miles both while training for a marathon (P = .015) and when not training for a marathon (P = .020) than women. Those runners who trained more years are more likely to work with a running coach (P = .000), run more miles (P = .057) and train longer (P = .104) during marathon training. The survey also revealed that majority of runners training on concrete during marathon training and when not training. Results also determined that majority of respondents cross-trained while marathon training (n=89) with their primary choices of cross-training activity being cycling (n=60) and strength training (n=59). 37 respondents worked with a running coach during marathon training with their primary motivation for doing so being to increase speed. While these findings may provide a better understanding of non-elite marathon runners and their training practices, further research should be conducted to even better understand this population. In all, this study provided an overall view of the motivations and training practices of non-elite marathon runners.Health & Human Performance (MS

The Southern Hospitals Report

When research for this report was first initiated, it was intended to answer a narrow question: is abortion care restricted at historically Protestant hospitals in the U.S. South? Strict limits on access to abortion at Catholic hospitals — and the ways in which this can obstruct and delay even emergency medical care — are already well documented in legal and medical literature and news media. In contrast, restrictions at Protestant hospitals have not been extensively studied and are not well understood. Our research sought to fill this gap in knowledge. We focused on the U.S. South because Catholic hospitals are less concentrated in the South than in other regions (especially the Midwest and Pacific Northwest), leaving Protestant hospitals to play a potentially larger role in the delivery of medical care

The metabolic impact of extracellular nitrite on aerobic metabolism of Paracoccus denitrificans

Nitrite, in equilibrium with free nitrous acid (FNA), can inhibit both aerobic and anaerobic growth of microbial communities through bactericidal activities that have considerable potential for control of microbial growth in a range of water systems. There has been much focus on the effect of nitrite / FNA on anaerobic metabolism and so, to enhance understanding of the metabolic impact of nitrite / FNA on aerobic metabolism, a study was undertaken with a model denitrifying bacterium Paracoccus denitrificans PD1222. Extracellular nitrite inhibits aerobic growth of P. denitrificans in a pH dependent manner that is likely to be a result of both nitrite and free nitrous acid (FNA) (pKa = 3.25) and subsequent reactive nitrogen oxides generated from the intracellular passage of FNA into P. denitrificans. Increased expression of a gene encoding a flavohemoglobin protein (Fhp) (Pden_1689) was observed in response to extracellular nitrite. Construction and analysis of a deletion mutant established the Fhp to be involved in endowing nitrite / FNA resistance at high extracellular nitrite concentrations. Global transcriptional analysis confirmed nitrite-dependent expression of fhp and indicated that P. denitrificans expressed a number of stress response systems associated with protein, DNA and lipid repair. It is therefore suggested that nitrite causes a pH-dependent stress response that is due to the production of associated reactive nitrogen species, such as NO from the internalisation of FNA

FolX from Pseudomonas aeruginosa is octameric in both crystal and solution

FolX encodes an epimerase that forms one step of the tetrahydrofolate biosynthetic pathway, which is of interest as it is an established target for important drugs. Here we report the crystal structure of FolX from the bacterial opportunistic pathogen Pseudomonas aeruginosa, as well as a detailed analysis of the protein in solution, using analytical ultracentrifugation (AUC) and small-angle X-ray scattering (SAXS). In combination, these techniques confirm that the protein is an octamer both in the crystal structure, and in solution

Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial

SummaryBackgroundSmall studies suggest peanut oral immunotherapy (OIT) might be effective in the treatment of peanut allergy. We aimed to establish the efficacy of OIT for the desensitisation of children with allergy to peanuts.MethodsWe did a randomised controlled crossover trial to compare the efficacy of active OIT (using characterised peanut flour; protein doses of 2–800 mg/day) with control (peanut avoidance, the present standard of care) at the NIHR/Wellcome Trust Cambridge Clinical Research Facility (Cambridge, UK). Randomisation (1:1) was by use of an audited online system; group allocation was not masked. Eligible participants were aged 7–16 years with an immediate hypersensitivity reaction after peanut ingestion, positive skin prick test to peanuts, and positive by double-blind placebo-controlled food challenge (DBPCFC). We excluded participants if they had a major chronic illness, if the care provider or a present household member had suspected or diagnosed allergy to peanuts, or if there was an unwillingness or inability to comply with study procedures. Our primary outcome was desensitisation, defined as negative peanut challenge (1400 mg protein in DBPCFC) at 6 months (first phase). Control participants underwent OIT during the second phase, with subsequent DBPCFC. Immunological parameters and disease-specific quality-of-life scores were measured. Analysis was by intention to treat. Fisher's exact test was used to compare the proportion of those with desensitisation to peanut after 6 months between the active and control group at the end of the first phase. This trial is registered with Current Controlled Trials, number ISRCTN62416244.FindingsThe primary outcome, desensitisation, was recorded for 62% (24 of 39 participants; 95% CI 45–78) in the active group and none of the control group after the first phase (0 of 46; 95% CI 0–9; p<0·001). 84% (95% CI 70–93) of the active group tolerated daily ingestion of 800 mg protein (equivalent to roughly five peanuts). Median increase in peanut threshold after OIT was 1345 mg (range 45–1400; p<0·001) or 25·5 times (range 1·82–280; p<0·001). After the second phase, 54% (95% CI 35–72) tolerated 1400 mg challenge (equivalent to roughly ten peanuts) and 91% (79–98) tolerated daily ingestion of 800 mg protein. Quality-of-life scores improved (decreased) after OIT (median change −1·61; p<0·001). Side-effects were mild in most participants. Gastrointestinal symptoms were, collectively, most common (31 participants with nausea, 31 with vomiting, and one with diarrhoea), then oral pruritus after 6·3% of doses (76 participants) and wheeze after 0·41% of doses (21 participants). Intramuscular adrenaline was used after 0·01% of doses (one participant).InterpretationOIT successfully induced desensitisation in most children within the study population with peanut allergy of any severity, with a clinically meaningful increase in peanut threshold. Quality of life improved after intervention and there was a good safety profile. Immunological changes corresponded with clinical desensitisation. Further studies in wider populations are recommended; peanut OIT should not be done in non-specialist settings, but it is effective and well tolerated in the studied age group.FundingMRC-NIHR partnership

Natural Inflation: Particle Physics Models, Power Law Spectra for Large Scale Structure, and Constraints from COBE

A pseudo-Nambu-Goldstone boson, with a potential of the form $V(\phi) = \Lambda^4[1 \pm \cos(\phi/f)], naturally gives rise to inflation if$f \sim M_{Pl}$and$\Lambda \sim M_{GUT}$. We show how this can arise in technicolor-like and superstring models, and work out an explicit string example in the context of multiple gaugino condensation models. We study the cosmology of this model in detail, and find that sufficient reheating to ensure that baryogenesis can take place requires$f > 0.3 M_{Pl}$. The primordial density fluctuation spectrum generated is a non-scale-invariant power law,$P(k) \propto k^{n_s}$, with$n_s \simeq 1 - (M^2_{Pl}/8\pi f^2)$, leading to more power on large length scales than the$n_s = 1$Harrison-Zeldovich spectrum. The standard CDM model with$0 \la n_s \la 0.6-0.7$could in principle explain the large-scale clustering observed in the APM and IRAS galaxy surveys as well as large-scale flows, but the COBE microwave anisotropy implies such low amplitudes (or high bias factors,$b>2$) for these CDM models that galaxy formation occurs too late to be viable; combining COBE with sufficiently early galaxy formation or the large-scale flows leads to$n_s >0.6$, or$f > 0.3 M_{Pl}$as well. For extended and power law inflation models, this constraint is even tighter,$n_s > 0.7$; combined with other bounds on large bubbles in extended inflation, this leaves little room for most extended models.Comment: 42 pages, (12 figures not included but available from the authors