Reader’s Advisory in the Academic Library: Should You? (Yes!) Could You? (Yes!)

This poster highlights the research surrounding the academic and social benefits of leisure reading among college students. A case scenario of the inclusion of a popular titles collection at an academic library is also included as an additional document

Together: Human Health and Our Environment Are Inextricably Linked

You are viewing an article about Planet Texas 2050 from April 2020.Office of the VP for Researc

Microwave Dielectric Heating of Drops in Microfluidic Devices

We present a technique to locally and rapidly heat water drops in microfluidic devices with microwave dielectric heating. Water absorbs microwave power more efficiently than polymers, glass, and oils due to its permanent molecular dipole moment that has a large dielectric loss at GHz frequencies. The relevant heat capacity of the system is a single thermally isolated picoliter drop of water and this enables very fast thermal cycling. We demonstrate microwave dielectric heating in a microfluidic device that integrates a flow-focusing drop maker, drop splitters, and metal electrodes to locally deliver microwave power from an inexpensive, commercially available 3.0 GHz source and amplifier. The temperature of the drops is measured by observing the temperature dependent fluorescence intensity of cadmium selenide nanocrystals suspended in the water drops. We demonstrate characteristic heating times as short as 15 ms to steady-state temperatures as large as 30 degrees C above the base temperature of the microfluidic device. Many common biological and chemical applications require rapid and local control of temperature, such as PCR amplification of DNA, and can benefit from this new technique.Comment: 6 pages, 4 figure

‘Radicalisation’: The Transformation of Modern Understanding of Terrorist Origins, Psychology and Motivation.

Our understanding of how people become involved in terrorism and violent extremism has transformed since the turn of the century. That transformation occurred at the same time that ‘radicalisation’ took over as the dominant framework for considering questions around terrorist psychology, motivation and recruitment. Today, radicalisation is typically seen to refer to a complex and dynamic process which results in individuals coming to embrace a violent ideology in support of a political or religious cause. The concept of radicalisation has become an almost universal element in contemporary efforts to understand and combat terrorism. This chapter outlines the rise and development of theoretical models and research on radicalisation. It highlights some of the major research breakthroughs but also focuses on where very significant gaps remain in our understanding. The chapter cautions that we need to be careful in terms of how we think about the broader role of radicalisation. A subtle – and dangerously unquestioned - assumption has spread that ‘radicalisation’ as a phenomenon is the major root cause of terrorism. When different radicalisation models are used to design or justify a variety of counter-terrorism policies and programmes, care is needed to look beyond the headline banner of radicalisation and pay attention to the factors identified within those models as key drivers

GIS, GPS, and Remote Sensing Technologies in Extension Services: Where to Start, What to Know

The rapid development and integration of spatial technologies such as Geographic Information Systems, the Global Positioning System, and remote sensing, have created many new tools for Extension professionals, but have also widened the digital divide, leaving many with little understanding of the technology and potential applications. This article presents examples of Extension-related applications of GIS-GPS-RS technologies and discusses how to go about learning more and determining if these technologies would be useful. Examples and recommendations are taken from the literature and from the authors\u27 own experience

Salmonella vaccines for use in humans: present and future perspectives.

In recent years there has been significant progress in the development of attenuated Salmonella enterica serovar Typhi strains as candidate typhoid fever vaccines. In clinical trials these vaccines have been shown to be well tolerated and immunogenic. For example, the attenuated S. enterica var. Typhi strains CVD 908-htrA (aroC aroD htrA), Ty800 (phoP phoQ) and chi4073 (cya crp cdt) are all promising candidate typhoid vaccines. In addition, clinical trials have demonstrated that S. enterica var. Typhi vaccines expressing heterologous antigens, such as the tetanus toxin fragment C, can induce immunity to the expressed antigens in human volunteers. In many cases, the problems associated with expression of antigens in Salmonella have been successfully addressed and the future of Salmonella vaccine development is very promising

DNA vaccines: improving expression of antigens

Copyright © 2003 Garmory et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.DNA vaccination is a relatively recent development in vaccine methodology. It is now possible to undertake a rational step-by-step approach to DNA vaccine design. Strategies may include the incorporation of immunostimulatory sequences in the backbone of the plasmid, co-expression of stimulatory molecules, utilisation of localisation/secretory signals, and utilisation of the appropriate delivery system, for example. However, another important consideration is the utilisation of methods designed to optimise transgene expression. In this review we discuss the importance of regulatory elements, kozak sequences and codon optimisation in transgene expression

Ancilla-based quantum simulation

We consider simulating the BCS Hamiltonian, a model of low temperature superconductivity, on a quantum computer. In particular we consider conducting the simulation on the qubus quantum computer, which uses a continuous variable ancilla to generate interactions between qubits. We demonstrate an O(N^3) improvement over previous work conducted on an NMR computer [PRL 89 057904 (2002) & PRL 97 050504 (2006)] for the nearest neighbour and completely general cases. We then go on to show methods to minimise the number of operations needed per time step using the qubus in three cases; a completely general case, a case of exponentially decaying interactions and the case of fixed range interactions. We make these results controlled on an ancilla qubit so that we can apply the phase estimation algorithm, and hence show that when N \geq 5, our qubus simulation requires significantly less operations that a similar simulation conducted on an NMR computer.Comment: 20 pages, 10 figures: V2 added section on phase estimation and performing controlled unitaries, V3 corrected minor typo

Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads † ‡

The reversible attachment of small molecules to oligonucleotides provides versatile tools for the development of improved oligonucleotide therapeutics. However, cleavable linkers in the oligonucleotide field are scarce, particularly with respect to the requirement for traceless release of the payload in vivo. Herein, we describe a cathepsin B-cleavable dipeptide phosphoramidite, Val-Ala(NB) for the automated synthesis of oligonucleotide-small molecule conjugates. Val-Ala(NB) was protected by a photolabile 2-nitrobenzyl group to improve the stability of the peptide linker during DNA synthesis. Intracellular cathepsin B digests the dipeptide efficiently, releasing the payload-phosphate which is converted to the free payload by endogenous phosphatase enzymes. With the advantages of modular synthesis and stimuli-responsive drug release, we believe Val-Ala(NB) will be a potentially valuable cleavable linker for use in oligonucleotide-drug conjugates