Papillary thyroid cancer associated with syndrome of inappropriate antidiuresis: a case report

<p>Abstract</p> <p>Introduction</p> <p>The syndrome of inappropriate antidiuresis is the most common cause of euvolemic hypo-osmolality. This syndrome is associated with a wide variety of diseases. However, its most frequent causes are related to malignancies, especially lung cancer. In this case report, we describe an unknown association of the syndrome of inappropriate antidiuresis with papillary thyroid cancer.</p> <p>Case presentation</p> <p>We present the case of a 71-year-old Caucasian, German woman with marked hyponatremia and neurological symptoms. After a detailed clinical investigation, the common causes of syndrome of inappropriate antidiuresis and other malignancies were ruled out. A thyroid nodule was detected by ultrasound and magnetic resonance imaging. Although fine needle aspiration cytology showed negative results, our patient underwent surgery. Papillary thyroid cancer was later diagnosed. After total thyroidectomy, a complete remission of the clinical symptoms occurred and our patient subsequently had iodine-131 radioactive therapy. Hyponatremia was no longer observed during the follow-up investigations.</p> <p>Conclusion</p> <p>This is the first reported case of paraneoplastic syndrome of inappropriate antidiuresis caused by papillary thyroid carcinoma. Since its symptoms occurred before the development of local symptoms, total thyroidectomy may provide a timely and efficient treatment for the underlying malignancy.</p

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

First International Workshop of the Tiss.EU Project: Rights and Entitlements in Human Tissue and Cells

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Barbara Bleisch, Andrea Büchler (2020) Kinder wollen. Über Autonomie und Verantwortung

&lt;jats:title&gt;Abstract&lt;/jats:title&gt;&lt;jats:p&gt;Metabasic rocks of the ophiolitic sequences of the Glockner Nappe and Eclogite Zone in the south-central Tauern Window, Austria, reveal important insights into rifting and spreading of the Alpine Tethys. U–Pb dating of magmatic zircons yields a concordant 157 ± 2 Ma crystallization age for the precursor of a coarse-grained metagabbro from the Glockner Nappe. The Late Jurassic intrusion age is coeval with mafic plutonic activity in the Western and Central Alps. Although Penninic ophiolitic sequences in tectonic windows of the Eastern Alps are usually disrupted, an ocean–continent transition setting can be reconstructed for the Glockner Nappe, similar to many ophiolites in the Liguria–Piemont domain in the Western and Central Alps. Together, these observations strongly suggest a formation in the Liguria–Piemont branch of the Alpine Tethys and are inconsistent with a formation in the Valais domain. This finding has important implications for paleogeographic reconstructions of the Penninic realm in the Eastern Alps. Whereas the Glockner Nappe metagabbro and metabasalts clearly reveal their depleted mantle origin, the metabasic rocks of the Eclogite Zone record a more complex formation history involving depleted mantle melting and crustal assimilation in a continental margin setting.&lt;/jats:p&gt

Ethical and Legas Aspects of Human Tissue and Biobank Research in Europe: Report on the Tiss.Eu-Projekt and its Results

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