17 research outputs found
Comparison of high -performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for determination of trimetazidine in pharmaceutical formulation
New methods for assaying trimetazidine dihydrochloride on the basis of thin layer chromatography and spectrophotometry are proposed and compared in the paper. In HPTLC/UV-densitometry, separation is achieved by using a mobile phase composed of ammonia-methanol (30:70, V/V) on silica gel HPTLC plates F254. Quantification using a non-linear calibration curve is accomplished by densitometric detection at 230 nm. Derivative spectrophotometric determination of trimetazidine dihydrochloride is carried out from the fourth derivative of the absorbance at 233 nm in peak-zero mode. Statistical comparison led to the conclusion that there is no significant difference between the two studied methods and, moreover, that they demonstrate satisfactory accuracy and precision for routine applications
Historia i rozw贸j leczenia b贸lu - przegl膮d wiedzy na temat post臋powania analgetycznego od staro偶ytno艣ci do czas贸w wsp贸艂czesnych = History and development of pain treatment - the literature review about analgetic procedures from antiquity to present day
G艂贸wczewska-Siedlecka Emilia, M膮dra-Gackowska Katarzyna, Nowacka Krystyna, K臋dziora-Kornatowska Kornelia. Historia i rozw贸j leczenia b贸lu - przegl膮d wiedzy na temat post臋powania analgetycznego od staro偶ytno艣ci do czas贸w wsp贸艂czesnych = History and development of pain treatment - the literature review about analgetic procedures from antiquity to present day. Journal of Education, Health and Sport. 2016;6(9):479-488. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.151626http://ojs.ukw.edu.pl/index.php/johs/article/view/3870聽聽聽The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7漏 The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.08.2016. Revised 25.08.2016. Accepted: 16.09.2016.聽聽聽Historia i rozw贸j leczenia b贸lu - przegl膮d wiedzy na temat post臋powania analgetycznego od staro偶ytno艣ci do czas贸w wsp贸艂czesnych聽History and development of pain treatment - the literature review about analgetic procedures from antiquity to present day聽G艂贸wczewska-Siedlecka Emilia1, M膮dra-Gackowska Katarzyna1, Nowacka Krystyna2, K臋dziora-Kornatowska Kornelia1聽1. Katedra i Klinika Geriatrii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu聽2. Katedra i Klinika Rehabilitacji, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu聽聽聽Streszczenie聽Zagadnienie leczenia b贸lu stanowi od zarania dziej贸w istotn膮 cz臋艣膰 medycyny. Od czas贸w najdawniejszych ludzie starali si臋 zwalcza膰 b贸l za pomoc膮 艣rodk贸w farmaceutycznych, zabieg贸w fizykalnych i procedur zabiegowych. Post臋powanie z b贸lem ewoluowa艂o od czas贸w staro偶ytnych a偶 po model wsp贸艂czesny charakteryzuj膮cy si臋 multidyscyplinarnym podej艣ciem i tworzeniem si臋 specjalistycznych centr贸w leczenia b贸lu. W niniejszej publikacji dokonano przegl膮du literatury celem ukazania historii i rozwoju leczenia b贸lu na tle historii medycyny oraz oceny jak wydarzenia z historii 艢wiata takie jak na przyk艂ad konflikty zbrojne wp艂ywa艂y na podej艣cie do leczenia b贸lu.聽S艂owa kluczowe: leczenie b贸lu, historia medycyny, leki przeciwb贸lowe聽聽Abstract聽Pain treatment presents important part of history of medicine from primaeval times.聽 Since these times people always tried to treat pain by the use of drugs, physical factors or operative procedures. Pain treatment has evolved since antiquity to present day, when modern model of pain treatment consist on multidisciplinary approach and creation聽 of specialistic pain treatment centers. This publication relies on the review of literature about pain treatment history. This publication show relaitons beetwen history of pain treatment and general history of medicine and also general history of World for example association beetwen wars and military conflicts and development of pain treatment procedures.聽Key words: pain treatment, history of medicine, analgetic drug
Medications of medieval monastery medicine
Herbal medicine has accompanied man since the dawn of time. For various ailments and health problems, help was sought in the surrounding nature. Ancient civilizations have greatly contributed to the development of phytotherapy, identifying and describing numerous species of medicinal plants. Plant raw materials have become the foundation of medieval medicine. The revival in herbal medicine has been observed since the sixth century with the emergence of monasteries, where the gardens in which the medicinal plants were grown were established. Monastic schools were also established, monks broadened their skills by studying and copying ancient books, preparing medicines of natural origin according to secret prescriptions used to heal the sick. Although the Middle Ages are often considered dark ages, many achievements of the then phytotherapy have been recorded on the pages of history and a man use them to this day
Przewlek艂y krwiak podtward贸wkowy u chorej przyj臋tej do Kliniki Geriatrii z powodu post臋puj膮cego ot臋pienia - opis przypadku = Chronic subdural hematoma in patient admitted to Geriatric Department because of progressive dementia - case report
G艂贸wczewska-Siedlecka Emilia, M膮dra-Gackowska Katarzyna, Nowacka Krystyna, Siedlecki Zygmunt, Szostak Mateusz, K臋dziora鈥慘ornatowska Kornelia. Przewlek艂y krwiak podtward贸wkowy u chorej przyj臋tej do Kliniki Geriatrii z powodu post臋puj膮cego ot臋pienia - opis przypadku = Chronic subdural hematoma in patient admitted to Geriatric Department because of progressive dementia - case report. Journal of Education, Health and Sport. 2016;6(11):398-403. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.168426http://ojs.ukw.edu.pl/index.php/johs/article/view/4015聽聽聽The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7漏 The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 01.11.2016. Revised 12.11.2016. Accepted: 25.11.2016.聽聽聽Przewlek艂y krwiak podtward贸wkowy u chorej przyj臋tej do Kliniki Geriatrii z powodu post臋puj膮cego ot臋pienia - opis przypadku聽Chronic subdural hematoma in patient admitted to Geriatric Department because of progressive dementia - case report聽G艂贸wczewska-Siedlecka Emilia1, M膮dra-Gackowska Katarzyna1, Nowacka Krystyna2, Siedlecki Zygmunt3, Szostak Mateusz3, K臋dziora-Kornatowska Kornelia1聽1. Katedra i Klinika Geriatrii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu2. Katedra i Klinika Rehabilitacji, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu3. Klinika Neurochirurgii, Neurotraumatologii i Neurochiurgii Dzieci臋cej, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu聽聽聽聽StreszczeniePrzewlek艂e krwiaki podtward贸wkowe s膮 schorzeniem typowym dla os贸b wieku podesz艂ym, objawia膰 si臋 mog膮 zaburzeniem funkcji poznawczych, co u starszych chorych wymaga r贸偶nicowania z post臋puj膮cym ot臋pieniem. W niniejszej publikacji przedstawiony jest przypadek 85-letniej chorej przyj臋tej do Kliniki Geriatrii CM UMK w Bydgoszczy z powodu objaw贸w post臋puj膮cego ot臋pienia. Badania psychologiczne wykaza艂y istotne odchylenia w zakresie funkcji poznawczych. W badaniu TK g艂owy wykazano obecno艣膰 rozleg艂ego przewlek艂ego krwiaka przym贸zgowego. Chora zosta艂a poddana leczeniu operacyjnemu drog膮 trepanacji otworkowej. Przebieg oko艂ooperacyjny by艂 niepowik艂any. Dwa tygodnie po zabiegu zaobserwowano popraw臋 w zakresie funkcji poznawczych. Opisany przypadek dowodzi znaczenia, jakie przewlek艂e krwiaki podtward贸wkowe odgrywaj膮 w艣r贸d chorych leczonych na oddzia艂ach geriatrycznych.聽S艂owa kluczowe: przewlek艂y krwiak podtward贸wkowy, ot臋pienie, geriatria聽聽聽AbstractChronic subdural hematomas (CSDH) are typical for elderly people, its symptoms can be cognitive impairment, which in older patients require differentiation of the progressive dementia. In this publication, we presented a case of 85-year-old patient admitted to the Department of Geriatrics of CM UMK in Bydgoszcz with symptoms of progressive dementia. Psychological tests showed significant cognitive impairment. The CT scan revealed the presence of extensive CSH. The patient underwent surgical treatment through burrhole. Perioperatively no complitations happened. Two weeks later improvement in cognitive function was observed. This case improved the importance of CSDH in geriatrics.聽Key words: CSDH, dementia, geriatric
A聽massive gross haematuria in an 85-year-old patient with acquired haemophilia A
The authors herein present a聽case report of an 85-year-old female patient with massive gross haematuria in the course of acquired haemophilia A. Acquired haemophilia in the geriatric population is a聽rare but severe bleeding disorder. It is caused by suddenly appearing autoantibodies that interfere with coagulation factor VIII activity. The diagnosis of acquired haemophilia should be considered in any patient who presents with bleeding and a聽prolonged activated partial thromboplastin time (APTT)
Results of conservative, surgical treatment and rehabilitation of entrapment neuropathies in elderly patients in geriatric practice
Entrapment neuropahies of upper limbs can cause mainly nocturnal neuropathic pain and impaired manual dexterity. The most common entrapment neuropathy is carpal tunnel syndrome and ulnar groove syndrome - ulnar nerve entrapment at the elbow. Treatment of entrapment neuropathies is both analgetic therapy and physiotherapy. In the cases of conservative treatment inefficiencies surgical decompression of nerves is performed. Authors of this oublication present results of both conservative聽 and surgical of entrapment neuropathies in patients over 65 years old. Among the 17 patients with entraoment neuropathies 12 of them underwent surgical treatment. Achieved partial improvement in pain, mostly nocturnal and improving the quality of life and dexterity. In comparison, however, a group of younger patients who underwent surgery for the improvement was less spectacular, which may testify advancement and irreversibility of changes in older patients
Zesp贸艂 s艂abo艣ci powik艂any z艂amaniami kompresyjnymi kr臋g贸w i silnymi zespo艂ami b贸lowymi kr臋gos艂upa - analiza przypadk贸w z propozycj膮 post臋powania terapeutycznego = Frailty syndrome with compression spine factures and severe back pain - the clinical analysis and suggested treatment
G艂贸wczewska-Siedlecka Emilia, M膮dra-Gackowska Katarzyna, Jaroch Alina, Nowacka聽Krystyna, Siedlecki Zygmunt, Szostak Mateusz, K臋dziora鈥慘ornatowska聽Kornelia. Zesp贸艂 s艂abo艣ci powik艂any z艂amaniami kompresyjnymi kr臋g贸w i silnymi zespo艂ami b贸lowymi kr臋gos艂upa - analiza przypadk贸w z propozycj膮 post臋powania terapeutycznego = Frailty syndrome with compression spine factures and severe back pain - the clinical analysis and suggested treatment. Journal of Education, Health and Sport. 2016;6(12):536-542. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.213480http://ojs.ukw.edu.pl/index.php/johs/article/view/4086聽聽聽聽The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016).754 Journal of Education, Health and Sport eISSN 2391-8306 7漏 The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 01.12.2016. Revised 12.12.2016. Accepted: 19.12.2016.聽聽聽聽Zesp贸艂 s艂abo艣ci powik艂any z艂amaniami kompresyjnymi kr臋g贸w i silnymi zespo艂ami b贸lowymi kr臋gos艂upa - analiza przypadk贸w z propozycj膮 post臋powania terapeutycznego聽Frailty syndrome with compression spine factures and severe back pain - the clinical analysis and suggested treatment聽G艂贸wczewska-Siedlecka Emilia1, M膮dra-Gackowska Katarzyna1, Jaroch Alina1, Nowacka聽Krystyna2, Siedlecki Zygmunt3, Szostak Mateusz3, K臋dziora鈥慘ornatowska聽Kornelia1聽1. Katedra i Klinika Geriatrii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu2. Katedra i Klinika Rehabilitacji, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu3. Klinika Neurochirurgii, Neurotraumatologii i Neurochiurgii Dzieci臋cej, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Miko艂aja Kopernika w Toruniu聽聽聽聽聽聽StreszczenieNiniejsza praca omawia przypadki 8 chorych hospitalizowanych w Klinice Geriatrii CM UMK z rozpoznanym wg kryteri贸w Fried zespo艂em s艂abo艣ci. U badanych chorych zaobserwowano spadek masy cia艂a w ci膮gu ostatniego roku, cechy depresji wg skali CES-D,聽 spowolnienie chodu oraz, os艂abienie si艂y mi臋艣niowej oraz b贸le kr臋gos艂upa o nasileniu 9 VAS. W badaniach obrazowych kr臋gos艂upa rozpoznano z艂amania kompresyjne kr臋g贸w, kt贸re poddano zabiegowi wertebroplastyki uzyskuj膮c popraw臋 w zakresie b贸lu, nast臋pnie u chorych wdro偶ono rehabilitacj臋 ambulatoryjn膮 oraz diet臋 wysokobia艂kow膮, po oko艂o 3 miesi膮cach u ka偶dego chorego uzyskano istotn膮 popraw臋 stanu klinicznego. Chorzy przestali spe艂nia膰 kryteria Fried, co dowodzi tego 偶e kompleksowe i cz臋sto wielodyscyplinarne post臋powanie korzystnie wp艂ywa na leczenie starszych chorych z zespo艂em s艂abo艣ci.聽S艂owa kluczowe: zesp贸艂 s艂abo艣ci, z艂amanie kompresyjne kr臋gu, dieta, rehabilitacja, wertebroplastyka聽聽聽AbstractAuthors present the cases of 8 patients treated in the Department of Geriatrics of CM UMK with frailty syndrome diagnosed. Patients showed a weight loss during the last year, signs of depression in CES-D scale, gait downturn, muscle weakness and severe back pain - 9 VAS. By imaging study the spinal fractures were diagnosed and patients underwent vertebroplasty obtaining good recovery in pain. Then patients have been implemented rehabilitation and high-protein diet. After about 3 months for each patient a significant clinical improvement was achieved. Patients no longer meet the Fried鈥檚 criteria for frailty. This proves that this complex and often multi-disciplinary proceeding is beneficial for the treatment of elderly patients with frailty syndrome.聽Key words: frailty, spine copression fracture, diet, rehabilitaion, vertebroplast
Assessment of the prevalence of nootropic drugs by elderly patients in geriatric practice
So-called nootropics include a diverse group of drugs whose idea is to improve brain function. They are quite commonly accepted among the elderly. Although currently available data from the literature do not show unequivocally the efficacy of these drugs, in practice a large number of patients are in practice. These drugs are prescribed to patients fairly commonly and the range of indications for their use is wide and non-specific. This publication presents the mechanism of action of these nootropic drugs, historical outline of their use and epidemiological data on their use in elderly patients on the basis of patients treated in the Department of Geriatrics of Medical University in Bydgoszcz
Correlation of tests used in Comprehensive Geriatric Assessment. Systematic Review
Perkowski Rados艂aw, Androsiuk Joanna, Kujawska Agnieszka, Gajos Ma艂gorzata, Kasperska Paulina, Topka Weronika, M膮dra-Gackowska Katarzyna,聽Romanowska Ewelina, P艂usa Sylwia, Aleksiewicz Tomasz, Ko偶uchowski Marcin, Biega艅ski Piotr, G艂贸wczewska-Siedlecka Emilia. Correlation of tests used in Comprehensive Geriatric Assessment. Systematic Review. Journal of Education, Health and Sport. 2016;6(7):207-217. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.57337http://ojs.ukw.edu.pl/index.php/johs/article/view/3686聽聽聽The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7漏 The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 15.06.2016. Revised 09.07.2016. Accepted: 09.07.2016.聽聽Correlation of tests used in Comprehensive Geriatric Assessment. Systematic Review聽Rados艂aw Perkowski1, Joanna Androsiuk1, Agnieszka Kujawska1, Ma艂gorzata Gajos1, Paulina Kasperska1, Weronika Topka1, Katarzyna M膮dra-Gackowska1, Ewelina聽Romanowska1, Sylwia P艂usa1, Tomasz Aleksiewicz1, Marcin Ko偶uchowski1, Piotr Biega艅ski2, Emilia G艂贸wczewska-Siedlecka1聽1. Katedra i Klinika Geriatrii, Wydzia艂 Nauk o Zdrowiu, Collegium Medicum UMK w Bydgoszczy2. Katedra Higieny, Epidemiologii i Ergonomii, Zak艂ad Ergonomii i Fizjologii Wysi艂ku Fizycznego聽Abstract Comprehensive Geriatric Assessment (CGA) has been used in clinics for almost 100 years. It includes holistic approach to patients examination. In this systematic review we analyzed results of tests used in CGA and correlation of results. Moreover, we underlined some issues concerning homogeneity of tests used in CGA as well as scientific validity of some of its tools.Results of prospective studies show that some of results of examination used in CGA are good predictors of functioning in another health domain in next years.Systolic blood pressure as well as BMI could be good predictors for neuropsychological functioning, however results are equivocal.Low scores in dual task (walking and cognitive engaging task simultaneously) are good predictor for falls occurrence. Education measured by socioeconomic status is very often mentioned as one of the best predictors of cognitive functioning.Undergoing Mini Nutritional Assessment by patients could be an effective tool to improve their nutrition status, possibly by indirectly influencing on their diet habits. Moreover, genotype examination could be worth to include into CGA due to, inter alia, examination of possible causes of dietary deficits.Aerobic examination could be done by cost-free tests, which sensitivity and specify are on tolerable level. It could help lowering CGA costs, which will help make it widely available for patients.聽Keywords: Comprehensive Geriatric Assessment, cognitive functioning, older people
Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status
Malnutrition is classified as one of the Giant Geriatric Syndromes. It carries serious consequences, such as sarcopenia or depression, which lead to functional disability. The main objective of this study was to identify parameters of oxidative stress and adipokines, which may be potential biomarkers of malnutrition in hospitalized older patients. During the study, selected parameters were determined in 137 senile patients, taking into account their nutritional status determined according to the Mini Nutritional Assessment (MNA), as well as an additional tool, namely the Geriatric Nutritional Risk Index (GNRI). Leptin and resistin were determined as the parameters with statistically significant differences between the patients classified according to the MNA. This phenomenon was confirmed using the GNRI classification. However, additional parameters for which differences were observed include the oxidized low-density lipoprotein level and activity of glutathione peroxidase. In conclusion, the determination of the mentioned markers in hospitalized senile patients as an adjunct to the routine assessment of nutritional status might be suggested to identify the early risk of malnutrition so that a personalized nutritional therapy can be implemented as early as possible