Comparison of high -performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for determination of trimetazidine in pharmaceutical formulation

New methods for assaying trimetazidine dihydrochloride on the basis of thin layer chromatography and spectrophotometry are proposed and compared in the paper. In HPTLC/UV-densitometry, separation is achieved by using a mobile phase composed of ammonia-methanol (30:70, V/V) on silica gel HPTLC plates F254. Quantification using a non-linear calibration curve is accomplished by densitometric detection at 230 nm. Derivative spectrophotometric determination of trimetazidine dihydrochloride is carried out from the fourth derivative of the absorbance at 233 nm in peak-zero mode. Statistical comparison led to the conclusion that there is no significant difference between the two studied methods and, moreover, that they demonstrate satisfactory accuracy and precision for routine applications

Historia i rozwój leczenia bólu - przegląd wiedzy na temat postępowania analgetycznego od starożytności do czasów współczesnych = History and development of pain treatment - the literature review about analgetic procedures from antiquity to present day

Główczewska-Siedlecka Emilia, Mądra-Gackowska Katarzyna, Nowacka Krystyna, Kędziora-Kornatowska Kornelia. Historia i rozwój leczenia bólu - przegląd wiedzy na temat postępowania analgetycznego od starożytności do czasów współczesnych = History and development of pain treatment - the literature review about analgetic procedures from antiquity to present day. Journal of Education, Health and Sport. 2016;6(9):479-488. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.151626http://ojs.ukw.edu.pl/index.php/johs/article/view/3870   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.08.2016. Revised 25.08.2016. Accepted: 16.09.2016.   Historia i rozwój leczenia bólu - przegląd wiedzy na temat postępowania analgetycznego od starożytności do czasów współczesnych History and development of pain treatment - the literature review about analgetic procedures from antiquity to present day Główczewska-Siedlecka Emilia1, Mądra-Gackowska Katarzyna1, Nowacka Krystyna2, Kędziora-Kornatowska Kornelia1 1. Katedra i Klinika Geriatrii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu 2. Katedra i Klinika Rehabilitacji, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu   Streszczenie Zagadnienie leczenia bólu stanowi od zarania dziejów istotną część medycyny. Od czasów najdawniejszych ludzie starali się zwalczać ból za pomocą środków farmaceutycznych, zabiegów fizykalnych i procedur zabiegowych. Postępowanie z bólem ewoluowało od czasów starożytnych aż po model współczesny charakteryzujący się multidyscyplinarnym podejściem i tworzeniem się specjalistycznych centrów leczenia bólu. W niniejszej publikacji dokonano przeglądu literatury celem ukazania historii i rozwoju leczenia bólu na tle historii medycyny oraz oceny jak wydarzenia z historii Świata takie jak na przykład konflikty zbrojne wpływały na podejście do leczenia bólu. Słowa kluczowe: leczenie bólu, historia medycyny, leki przeciwbólowe  Abstract Pain treatment presents important part of history of medicine from primaeval times.  Since these times people always tried to treat pain by the use of drugs, physical factors or operative procedures. Pain treatment has evolved since antiquity to present day, when modern model of pain treatment consist on multidisciplinary approach and creation  of specialistic pain treatment centers. This publication relies on the review of literature about pain treatment history. This publication show relaitons beetwen history of pain treatment and general history of medicine and also general history of World for example association beetwen wars and military conflicts and development of pain treatment procedures. Key words: pain treatment, history of medicine, analgetic drug

Medications of medieval monastery medicine

Herbal medicine has accompanied man since the dawn of time. For various ailments and health problems, help was sought in the surrounding nature. Ancient civilizations have greatly contributed to the development of phytotherapy, identifying and describing numerous species of medicinal plants. Plant raw materials have become the foundation of medieval medicine. The revival in herbal medicine has been observed since the sixth century with the emergence of monasteries, where the gardens in which the medicinal plants were grown were established. Monastic schools were also established, monks broadened their skills by studying and copying ancient books, preparing medicines of natural origin according to secret prescriptions used to heal the sick. Although the Middle Ages are often considered dark ages, many achievements of the then phytotherapy have been recorded on the pages of history and a man use them to this day

Przewlekły krwiak podtwardówkowy u chorej przyjętej do Kliniki Geriatrii z powodu postępującego otępienia - opis przypadku = Chronic subdural hematoma in patient admitted to Geriatric Department because of progressive dementia - case report

Główczewska-Siedlecka Emilia, Mądra-Gackowska Katarzyna, Nowacka Krystyna, Siedlecki Zygmunt, Szostak Mateusz, Kędziora‑Kornatowska Kornelia. Przewlekły krwiak podtwardówkowy u chorej przyjętej do Kliniki Geriatrii z powodu postępującego otępienia - opis przypadku = Chronic subdural hematoma in patient admitted to Geriatric Department because of progressive dementia - case report. Journal of Education, Health and Sport. 2016;6(11):398-403. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.168426http://ojs.ukw.edu.pl/index.php/johs/article/view/4015   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 01.11.2016. Revised 12.11.2016. Accepted: 25.11.2016.   Przewlekły krwiak podtwardówkowy u chorej przyjętej do Kliniki Geriatrii z powodu postępującego otępienia - opis przypadku Chronic subdural hematoma in patient admitted to Geriatric Department because of progressive dementia - case report Główczewska-Siedlecka Emilia1, Mądra-Gackowska Katarzyna1, Nowacka Krystyna2, Siedlecki Zygmunt3, Szostak Mateusz3, Kędziora-Kornatowska Kornelia1 1. Katedra i Klinika Geriatrii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu2. Katedra i Klinika Rehabilitacji, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu3. Klinika Neurochirurgii, Neurotraumatologii i Neurochiurgii Dziecięcej, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu    StreszczeniePrzewlekłe krwiaki podtwardówkowe są schorzeniem typowym dla osób wieku podeszłym, objawiać się mogą zaburzeniem funkcji poznawczych, co u starszych chorych wymaga różnicowania z postępującym otępieniem. W niniejszej publikacji przedstawiony jest przypadek 85-letniej chorej przyjętej do Kliniki Geriatrii CM UMK w Bydgoszczy z powodu objawów postępującego otępienia. Badania psychologiczne wykazały istotne odchylenia w zakresie funkcji poznawczych. W badaniu TK głowy wykazano obecność rozległego przewlekłego krwiaka przymózgowego. Chora została poddana leczeniu operacyjnemu drogą trepanacji otworkowej. Przebieg okołooperacyjny był niepowikłany. Dwa tygodnie po zabiegu zaobserwowano poprawę w zakresie funkcji poznawczych. Opisany przypadek dowodzi znaczenia, jakie przewlekłe krwiaki podtwardówkowe odgrywają wśród chorych leczonych na oddziałach geriatrycznych. Słowa kluczowe: przewlekły krwiak podtwardówkowy, otępienie, geriatria   AbstractChronic subdural hematomas (CSDH) are typical for elderly people, its symptoms can be cognitive impairment, which in older patients require differentiation of the progressive dementia. In this publication, we presented a case of 85-year-old patient admitted to the Department of Geriatrics of CM UMK in Bydgoszcz with symptoms of progressive dementia. Psychological tests showed significant cognitive impairment. The CT scan revealed the presence of extensive CSH. The patient underwent surgical treatment through burrhole. Perioperatively no complitations happened. Two weeks later improvement in cognitive function was observed. This case improved the importance of CSDH in geriatrics. Key words: CSDH, dementia, geriatric

A massive gross haematuria in an 85-year-old patient with acquired haemophilia A

The authors herein present a case report of an 85-year-old female patient with massive gross haematuria in the course of acquired haemophilia A. Acquired haemophilia in the geriatric population is a rare but severe bleeding disorder. It is caused by suddenly appearing autoantibodies that interfere with coagulation factor VIII activity. The diagnosis of acquired haemophilia should be considered in any patient who presents with bleeding and a prolonged activated partial thromboplastin time (APTT)

Results of conservative, surgical treatment and rehabilitation of entrapment neuropathies in elderly patients in geriatric practice

Entrapment neuropahies of upper limbs can cause mainly nocturnal neuropathic pain and impaired manual dexterity. The most common entrapment neuropathy is carpal tunnel syndrome and ulnar groove syndrome - ulnar nerve entrapment at the elbow. Treatment of entrapment neuropathies is both analgetic therapy and physiotherapy. In the cases of conservative treatment inefficiencies surgical decompression of nerves is performed. Authors of this oublication present results of both conservative  and surgical of entrapment neuropathies in patients over 65 years old. Among the 17 patients with entraoment neuropathies 12 of them underwent surgical treatment. Achieved partial improvement in pain, mostly nocturnal and improving the quality of life and dexterity. In comparison, however, a group of younger patients who underwent surgery for the improvement was less spectacular, which may testify advancement and irreversibility of changes in older patients

Zespół słabości powikłany złamaniami kompresyjnymi kręgów i silnymi zespołami bólowymi kręgosłupa - analiza przypadków z propozycją postępowania terapeutycznego = Frailty syndrome with compression spine factures and severe back pain - the clinical analysis and suggested treatment

Główczewska-Siedlecka Emilia, Mądra-Gackowska Katarzyna, Jaroch Alina, Nowacka Krystyna, Siedlecki Zygmunt, Szostak Mateusz, Kędziora‑Kornatowska Kornelia. Zespół słabości powikłany złamaniami kompresyjnymi kręgów i silnymi zespołami bólowymi kręgosłupa - analiza przypadków z propozycją postępowania terapeutycznego = Frailty syndrome with compression spine factures and severe back pain - the clinical analysis and suggested treatment. Journal of Education, Health and Sport. 2016;6(12):536-542. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.213480http://ojs.ukw.edu.pl/index.php/johs/article/view/4086    The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016).754 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 01.12.2016. Revised 12.12.2016. Accepted: 19.12.2016.    Zespół słabości powikłany złamaniami kompresyjnymi kręgów i silnymi zespołami bólowymi kręgosłupa - analiza przypadków z propozycją postępowania terapeutycznego Frailty syndrome with compression spine factures and severe back pain - the clinical analysis and suggested treatment Główczewska-Siedlecka Emilia1, Mądra-Gackowska Katarzyna1, Jaroch Alina1, Nowacka Krystyna2, Siedlecki Zygmunt3, Szostak Mateusz3, Kędziora‑Kornatowska Kornelia1 1. Katedra i Klinika Geriatrii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu2. Katedra i Klinika Rehabilitacji, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu3. Klinika Neurochirurgii, Neurotraumatologii i Neurochiurgii Dziecięcej, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu      StreszczenieNiniejsza praca omawia przypadki 8 chorych hospitalizowanych w Klinice Geriatrii CM UMK z rozpoznanym wg kryteriów Fried zespołem słabości. U badanych chorych zaobserwowano spadek masy ciała w ciągu ostatniego roku, cechy depresji wg skali CES-D,  spowolnienie chodu oraz, osłabienie siły mięśniowej oraz bóle kręgosłupa o nasileniu 9 VAS. W badaniach obrazowych kręgosłupa rozpoznano złamania kompresyjne kręgów, które poddano zabiegowi wertebroplastyki uzyskując poprawę w zakresie bólu, następnie u chorych wdrożono rehabilitację ambulatoryjną oraz dietę wysokobiałkową, po około 3 miesiącach u każdego chorego uzyskano istotną poprawę stanu klinicznego. Chorzy przestali spełniać kryteria Fried, co dowodzi tego że kompleksowe i często wielodyscyplinarne postępowanie korzystnie wpływa na leczenie starszych chorych z zespołem słabości. Słowa kluczowe: zespół słabości, złamanie kompresyjne kręgu, dieta, rehabilitacja, wertebroplastyka   AbstractAuthors present the cases of 8 patients treated in the Department of Geriatrics of CM UMK with frailty syndrome diagnosed. Patients showed a weight loss during the last year, signs of depression in CES-D scale, gait downturn, muscle weakness and severe back pain - 9 VAS. By imaging study the spinal fractures were diagnosed and patients underwent vertebroplasty obtaining good recovery in pain. Then patients have been implemented rehabilitation and high-protein diet. After about 3 months for each patient a significant clinical improvement was achieved. Patients no longer meet the Fried’s criteria for frailty. This proves that this complex and often multi-disciplinary proceeding is beneficial for the treatment of elderly patients with frailty syndrome. Key words: frailty, spine copression fracture, diet, rehabilitaion, vertebroplast

Assessment of the prevalence of nootropic drugs by elderly patients in geriatric practice

So-called nootropics include a diverse group of drugs whose idea is to improve brain function. They are quite commonly accepted among the elderly. Although currently available data from the literature do not show unequivocally the efficacy of these drugs, in practice a large number of patients are in practice. These drugs are prescribed to patients fairly commonly and the range of indications for their use is wide and non-specific. This publication presents the mechanism of action of these nootropic drugs, historical outline of their use and epidemiological data on their use in elderly patients on the basis of patients treated in the Department of Geriatrics of Medical University in Bydgoszcz

Correlation of tests used in Comprehensive Geriatric Assessment. Systematic Review

Perkowski Radosław, Androsiuk Joanna, Kujawska Agnieszka, Gajos Małgorzata, Kasperska Paulina, Topka Weronika, Mądra-Gackowska Katarzyna, Romanowska Ewelina, Płusa Sylwia, Aleksiewicz Tomasz, Kożuchowski Marcin, Biegański Piotr, Główczewska-Siedlecka Emilia. Correlation of tests used in Comprehensive Geriatric Assessment. Systematic Review. Journal of Education, Health and Sport. 2016;6(7):207-217. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.57337http://ojs.ukw.edu.pl/index.php/johs/article/view/3686   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 15.06.2016. Revised 09.07.2016. Accepted: 09.07.2016.  Correlation of tests used in Comprehensive Geriatric Assessment. Systematic Review Radosław Perkowski1, Joanna Androsiuk1, Agnieszka Kujawska1, Małgorzata Gajos1, Paulina Kasperska1, Weronika Topka1, Katarzyna Mądra-Gackowska1, Ewelina Romanowska1, Sylwia Płusa1, Tomasz Aleksiewicz1, Marcin Kożuchowski1, Piotr Biegański2, Emilia Główczewska-Siedlecka1 1. Katedra i Klinika Geriatrii, Wydział Nauk o Zdrowiu, Collegium Medicum UMK w Bydgoszczy2. Katedra Higieny, Epidemiologii i Ergonomii, Zakład Ergonomii i Fizjologii Wysiłku Fizycznego Abstract Comprehensive Geriatric Assessment (CGA) has been used in clinics for almost 100 years. It includes holistic approach to patients examination. In this systematic review we analyzed results of tests used in CGA and correlation of results. Moreover, we underlined some issues concerning homogeneity of tests used in CGA as well as scientific validity of some of its tools.Results of prospective studies show that some of results of examination used in CGA are good predictors of functioning in another health domain in next years.Systolic blood pressure as well as BMI could be good predictors for neuropsychological functioning, however results are equivocal.Low scores in dual task (walking and cognitive engaging task simultaneously) are good predictor for falls occurrence. Education measured by socioeconomic status is very often mentioned as one of the best predictors of cognitive functioning.Undergoing Mini Nutritional Assessment by patients could be an effective tool to improve their nutrition status, possibly by indirectly influencing on their diet habits. Moreover, genotype examination could be worth to include into CGA due to, inter alia, examination of possible causes of dietary deficits.Aerobic examination could be done by cost-free tests, which sensitivity and specify are on tolerable level. It could help lowering CGA costs, which will help make it widely available for patients. Keywords: Comprehensive Geriatric Assessment, cognitive functioning, older people

Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status

Malnutrition is classified as one of the Giant Geriatric Syndromes. It carries serious consequences, such as sarcopenia or depression, which lead to functional disability. The main objective of this study was to identify parameters of oxidative stress and adipokines, which may be potential biomarkers of malnutrition in hospitalized older patients. During the study, selected parameters were determined in 137 senile patients, taking into account their nutritional status determined according to the Mini Nutritional Assessment (MNA), as well as an additional tool, namely the Geriatric Nutritional Risk Index (GNRI). Leptin and resistin were determined as the parameters with statistically significant differences between the patients classified according to the MNA. This phenomenon was confirmed using the GNRI classification. However, additional parameters for which differences were observed include the oxidized low-density lipoprotein level and activity of glutathione peroxidase. In conclusion, the determination of the mentioned markers in hospitalized senile patients as an adjunct to the routine assessment of nutritional status might be suggested to identify the early risk of malnutrition so that a personalized nutritional therapy can be implemented as early as possible