Hashimoto thyroiditis in children with diabetes mellitus type 1

Choroba Hashimoto jest najczęstszą postacią autoimmunologicznych schorzeń tarczycy oraz jednocześnie najczęstszą chorobą autoimmunologiczną współwystępującą z cukrzycą typu 1. W pracy przedstawiono aktualne światowe doniesienia dotyczące etiologii, obrazu klinicznego, badań przesiewowych, diagnostyki i leczenia choroby Hashimoto u dzieci z cukrzycą typu 1. Podjęto ponadto dyskusję dotyczącą włączenia leczenia substytucyjnego hormonami tarczycy u dzieci z cukrzycą typu 1 i współistniejącym autoimmunologicznym zapaleniem tarczycy. (Diabet. Prakt. 2010; 11, 3: 89–93)Hashimoto thyroiditis is the most common autoimmune thyroid disease as well as the most often concomitant autoimmune disorder coexisting with diabetes mellitus type 1 (DM1). In this paper etiology, screening methods, symptoms and management of Hashimoto thyroiditis are discussed. Discussion involves the right point of beginning thyroid hormone replacement treatment in children with DM1. (Diabet. Prakt. 2010; 11, 3: 89–93

Dietary supplementation in type II diabetes mellitus in the light of the recent studies

Stan przedcukrzycowy stanowi istotny czynnik ryzyka rozwoju cukrzycy typu 2, dlatego istotne jest wczesne wykrywanie zaburzeń gospodarki węglowodanowej oraz działania prewencyjne na podstawie zmiany stylu życia. W ciągu ostatnich trzech lat opublikowano badania wskazujące na korzystny wpływ suplementacji składników dietetycznych na insulinowrażliwość tkanek.Pre-diabetes is an import ant risk factor for the development of type 2 diabetes, therefore early detection of glucose metabolism disorders and disease prevention by lifestyle changes are very important. In the past three years studies showing beneficial effect of dietary supplementation on insulin sensitivity were published

The structure-catalytic activity relationship for the transient layered zeolite MCM-56 with MWW topology

Zeolite MCM-56 is a high alumina, monolayered form of the commercially useful framework MWW but it is a transient product during crystallization, so many factors influence its state and quality. This work examines properties of a series of MCM-56 and MCM-49 samples synthesized for different times using Aerosil, Ultrasil and Ludox as silica sources, hexamethyleneimine as the structure directing agent and additionally aniline as structure promoting agent. It was found that the most important parameter, governing the catalytic activity in the test reaction of Friedel-Crafts alkylation of mesitylene with benzyl alcohol, was availability of the Brønsted acid centers located at the external surfaces of the crystals. The key role in correlating physical characteristic with activity was played by infrared spectroscopy as it enabled the study of many properties of the tested materials, starting from the total concentration of acid centers, and their type (Brønsted or Lewis acids) through the concentration of centers available for the reagent molecules, to investigating the correlation of acidity with the degree of zeolite crystallinity

Galectin-3: a potential biomarker for diagnostics of heart failure

Heart failure is a dysfunction with varied ethology; one of possible causes is anticancer treatment with anthracyclines. Rapid diagnosis is important because the disease is associated with high mortality and morbidity. The only biomarkers fully approved for diagnostics of heart failure are natriuretic peptides. They are secreted by ventricular muscle cells in response to volume and pressure overload. However, their concentration can be influenced by other factors, such as age or gender. A potential marker, not affected by these issues might be galectin-3. Current studies showed that galectin can play particularly significant role in myocardial fibrosis and inflammation. Elevated galectin-3 concentration has been observed in such cardiovascular diseases as heart failure,  atherosclerosis, stroke and myocardial infarction. The review summarizes results of studies which indicate the role of galectin-3 in inducing fibrosis and cardiac remodelling (processes which influence disease progression and prognosis) and showed its potential diagnostic value.Heart failure is a dysfunction with varied ethology; one of possible causes is anticancer treatment with anthracyclines. Rapid diagnosis is important because the disease is associated with high mortality and morbidity. The only biomarkers fully approved for diagnostics of heart failure are natriuretic peptides. They are secreted by ventricular muscle cells in response to volume and pressure overload. However, their concentration can be influenced by other factors, such as age or gender. A potential marker, not affected by these issues might be galectin-3. Current studies showed that galectin can play particularly significant role in myocardial fibrosis and inflammation. Elevated galectin-3 concentration has been observed in such cardiovascular diseases as heart failure,  atherosclerosis, stroke and myocardial infarction. The review summarizes results of studies which indicate the role of galectin-3 in inducing fibrosis and cardiac remodelling (processes which influence disease progression and prognosis) and showed its potential diagnostic value

L-arginina w chorobach układu sercowo-naczyniowego

L-arginine is an aminoacid which has many functions in humanorganism. It is the precursor for the synthesis of moleculesof great biological importance e.g nitric oxide or creatine.The discovery of the metabolic route L-arginine–nitrogenoxide disclosed new, wide possibilities of the therapeuticuse of the L-arginine especially in diseases with the dysfunctionof the endothelium, eg. arterial hypertension.L-arginina to aminokwas pełniący wiele funkcjiw organizmie człowieka. Jest prekursorem syntezy wieluważnych związków, np. tlenku azotu czy kreatyny.Odkrycie szlaku metabolicznego L-arginina–NOujawniło nowe, szerokie możliwości terapeutycznegozastosowania L-argininy zwłaszcza w chorobachprzebiegających z dysfunkcją śródbłonka, m.in. nadciśnieniutętniczym

Pulmonary embolism after anti-SARS-CoV-2 vaccines in two female patients

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. To protect people from severe COVID-19 course, vaccines have been recently developed. Vaccines’ safety was confirmed during clinical trials; however, massive vaccination action resulted in rare cases of adverse effects emerging, such as thromboses associated with thrombocytopenia. We present two cases of pulmonary embolism after anti-SARS-CoV-2 vaccines in two female patients, with negative history of SARS-CoV-2 infections. In both patients additional risk factors for thrombotic events (hormonal contraception, varicose veins) were present. Pulmonary embolism occurs when a blood vessel in the lungs becomes blocked by a blood clot. It is a very rare adverse effect associated with COVID-19 vaccines and is often accompanied by thrombocytopenia. However, recent studies have found that he incidence of pulmonary embolism after COVID-19 vaccines was not increased compared to the general population. Moreover, the risk of PE after vaccination is significantly lower than the incidence of thrombotic events during COVID-19

Antioxidant, Organoleptic and Physicochemical Changes in Different Marinated Oven-Grilled Chicken Breast Meat

The antioxidant, organoleptic, and physicochemical changes in different marinated oven-grilled chicken breast meat were investigated. Specifically, the chicken breast meat samples were procured from a local retailer in Wroclaw, Poland. The antioxidant aspects involved 2,2′-azinobis-(3-ethylbenzthiazolin-6-sulfonic acid) (ABTS), 1,1-diphenyl-2-pierylhydrazy (DPPH), and ferric-reducing antioxidant power (FRAP). The organoleptic aspects involved sensory and texture aspects. The physicochemical aspects involved the pH, thiobarbituric acid reactive substance (TBARS), cooking weight loss, L* a* b* color, and textural cutting force. Different marination variants comprised incremental 0.5, 1, and 1.5% concentrations of Baikal skullcap (BS), cranberry pomace (CP), and grape pomace (GP) that depicted antioxidants, and subsequently incorporated either African spice (AS) or an industrial marinade/pickle (IM). The oven grill facility was set at a temperature of 180 °C and a constant cooking time of 5 min. Results showed various antioxidant, organoleptic and physicochemical range values across the different marinated oven-grilled chicken breast meat samples, most of which appeared somewhat limited. Incorporating either AS or IM seemingly widens the ABTS and FRAP ranges, with much less for the DPPH. Moreover, with increasing CP, GP, and BS concentrations, fluctuations seemingly persist in pH, TBARS, cooking weight loss, L* a* b* color, and textural cutting force values even when either AS or IM was incorporated, despite resemblances in some organoleptic sensory and texture profiles. Overall, the oven-grilling approach promises to moderate the antioxidant, organoleptic, and physicochemical value ranges in the different marinated chicken breast meat samples in this study.info:eu-repo/semantics/publishedVersio

Cardiotoxicity of anticancer treatments

 Kardiotoksyczność chemioterapii lub radioterapii ma istotny wpływ na jakość życia oraz przedwcze­sny zgon pacjentów onkologicznych. Pacjenci przyjmujący chemioterapię stanowią grupę pod­wyższonego ryzyka zdarzeń sercowych — wśród nich najczęściej pojawiającym się powikłaniem jest dysfunkcja lewej komory z niewydolnością serca lub bez niej. W zależności od zastosowanej terapii toksyczność ta może być przemijająca lub trwała. Najlepiej poznane są powikłania kardiolo­giczne indukowane antracyklinami i trastuzuma­bem, lecz ich diagnostyka, prewencja i leczenie pozostają przedmiotem dalszych badań. W ni­niejszej pracy przedstawiono aktualny stan wie­dzy dotyczący definicji, czynników ryzyka oraz diagnostyki powikłań kardiologicznych terapii przeciwnowotworowej.Cardiotoxicity of chemotherapy or radiation the­rapy has a significant impact on quality of life and premature death of cancer patients. Patients receiving chemotherapy are at a higher risk of cardiac events, most commonly left ventricular dysfunction with or without heart failure. De­pending on the applied therapy, toxicity may be transient or permanent. Cardiac complications induced by anthracyclines and trastuzumab are the best know ones but their diagnosis, preven­tion and treatment remain the subject of further research. This paper presents the current state of knowledge concerning the definition, risk fac­tors and diagnosis of cardiac complications of cancer therapy

Quality attributes of different marinated oven-grilled pork neck meat

Whereas herbs/spices serve as natural preservatives, and thermal processing makes animal meat products edible, combining them should complement each other. Additionally, the application of oven grilling to meat products continues to increase in popularity. However, there is a paucity of relevant published information specific to different marinated oven-grilled pork neck meat. Therefore, the quality attributes of different marinated oven-grilled pork neck meat were investigated, which involved chemical (pH, thiobarbituric acid reactive substance [TBARS], 2,2′-azinobis(3-ethylbenzothiaziline-6-sulfonate) [ABTS], 1,1-diphenyl-2-pierylhydrazy [DPPH], ferric reducing antioxidant power [FRAP]), physical (cooking weight loss, L*a*b* color, and textural cutting force), as well as organoleptic (sensory: flavor, appearance, tenderness, taste, and off-flavor; texture: hardness, chewiness, gumminess, graininess, and greasiness) aspects. In particular, the pork neck meat was procured from a porcine farm in Poland. Different marinated variants comprised constituent 0.5, 1, and 1.5% quantities of cranberry pomace (CP), grape pomace (GP), and Baikal skullcap (BS) that subsequently incorporated either African spice (AS) or industrial marinade/pickle (IM). Results showed decreases in ABTS, DPPH, FRAP, and TBARS in some marinated oven-grilled pork neck meat samples, alongside pH variations by difference that seemingly associated with increasing concentrations of either CP, BS, or GP, which might not always coincide with L*a*b* color trends as AS and IM were incorporated. Despite the many resemblances (p > .05), the sensory aspects fluctuated as textural chewiness, gumminess, and hardness increased in some samples, more evident when incorporating AS compared to IM. Overall, oven-grilling promises to moderate the range values of key quality attributes of different marinated pork neck meat samples in this study.info:eu-repo/semantics/publishedVersio