20 research outputs found
Hypertension treatment preferences in long-term dialysed children in Poland - a survey of pediatric nephrologists
Wst臋p Przewlek艂a choroba nerek prowadzi do rozwoju
nadci艣nienia t臋tniczego u wi臋kszo艣ci chorych.
Leczenie nadci艣nienia towarzysz膮cego niewydolno艣ci
nerek jest utrudnione przez ograniczenia w stosowaniu
wielu preparat贸w i brak wystarczaj膮cych do艣wiadcze艅
klinicznych, a ponadto istniej膮ce obecnie
rekomendacje nie obejmuj膮 w og贸le chorych ze
schy艂kow膮 niewydolno艣ci膮 nerek. Wyb贸r terapii hipotensyjnej
ogranicza te偶 m艂ody wiek chorych, gdy偶
wielu lek贸w nie mo偶na stosowa膰 u dzieci. Celem
badania by艂a analiza jako艣ci leczenia przeciwnadci艣nieniowego
u dzieci ze schy艂kow膮 niewydolno艣ci膮
nerek poddawanych przewlek艂ej dializoterapii.
Materia艂 i metody Analiz膮 obj臋to wszystkie dzieci dializowane
w Polsce w dniu 30 listopada 2004 roku (n = 134).
Uzyskano informacje dotycz膮ce grup stosowanych lek贸w
oraz dawek preparat贸w, a tak偶e opinie lekarzy na
temat doboru lek贸w stosowanych przy nag艂ym wzro艣cie
ci艣nienia t臋tniczego oraz tych, kt贸rych dzieciom
dializowanym nie powinno si臋 podawa膰.
Wyniki Nadci艣nienie t臋tnicze stwierdzono u 74 (55%)
dzieci (47 ch艂opc贸w, 27 dziewczynek). Najcz臋stsz膮
przyczyn膮 niewydolno艣ci nerek w grupie dzieci z nadci艣nieniem
by艂o k艂臋buszkowe zapalenie nerek (27/74).
W badanej grupie 65% dzieci leczono za pomoc膮 kilku
lek贸w hipotensyjnych, 32% za pomoc膮 jednego
leku, a 3% jedynie metodami niefarmakologicznymi.
Mimo aktywnego leczenia, zaledwie u 58% dializowanych
dzieci prowadzi艂o ono do obni偶enia warto艣ci
ci艣nienia t臋tniczego poni偶ej 95 percentyla dla wzrostu
i wieku. Najmniejsz膮 skuteczno艣膰 kontroli ci艣nienia
t臋tniczego obserwowano w przypadku leczenia skojarzonego,
zw艂aszcza wielolekowego.
Najcz臋艣ciej stosowanymi lekami byli antagoni艣ci
wapnia, kt贸re podawano u og贸艂em 73% dzieci, w tym
u 43/48 w politerapii, a 11/24 w monoterapii. Inhibitory konwertazy angiotensyny by艂y najcz臋艣ciej stosowane
w monoterapii (50%). Mimo znanych kontrowersji,
przy nag艂ym wzro艣cie ci艣nienia t臋tniczego stosowano
najcz臋艣ciej nifedipin臋.
Wnioski Badanie wykaza艂o, 偶e w Polsce odsetek dializowanych
dzieci wymagaj膮cych leczenia nadci艣nieniowego
si臋ga 55%, w tym wi臋kszo艣膰 z nich wymaga
podawania kilku lek贸w. Pomimo 偶e zasady leczenia
s膮 podobne we wszystkich o艣rodkach, skuteczno艣膰
leczenia pozostaje niezadowalaj膮ca (58%).Background Chronic kidney disease is associated with the
development of arterial hypertension in a vast majority of
patients. The treatment of hypertension in these subjects is
difficult and challenging due to a limited clinical experience
with most drugs and no widely recognised recommendations
for patients with end-stage renal disease. A choice of
antihypertensive drugs is further narrowed by the young age
of the patients since almost all drugs are not recommended
in children with renal failure. The aim of this nationwide
retrospective analysis was to assess the hypertension treatment
patterns in the population of children with chronic
kidney diseases (CKD) undergoing hemodialysis or peritoneal
dialysis in Poland.
Material and methods Among all 134 children dialysed on
30th November 2004 in 13 pediatric dialysis centres in Poland
seventy four (55%; 47M, 27F) children were hypertensive.
For each patients the treating physicians filled a questionnaire
that allowed to collect the following data: the primary
kidney disease, chronic dialysis treatment, diagnostic
criteria of hypertension and present antihypertensive medication
if any. Additionally we asked of the doctors’ preference
for a therapy for the acute rise in blood pressure and
suggestions which drugs, in their opinion, should not be
used in dialysed children. Results In the hypertensive dialysed patients the most frequent
causes of chronic kidney disease were chronic
glomerulopathies (27/74). Thirty two percent of children
were on monotherapy whereas 65% required combined treatment.
The therapy was adequate only in 58% of subjects.
The lowest rate of efficacy was detected in patients requiring
a combined antihypertensive therapy.
Among antihypertensive drug classes calcium channel blockers
were administered most frequently (in 73% of children, in 11/24 cases in monotherapy and in 43/48 patients in combination).
Angiotensin converting enzyme inhibitors were most
frequently administered in monotheraphy (50%). Nifedipine
was preferred in acute blood pressure rise in children.
Conclusion We conclude that incidence of hypertension
in dialysed children in Poland is relatively high. The pattern
of the treatment was quite uniform, although the efficacy
was relatively low (58%)
Perception of health-related quality of life in children with chronic kidney disease by the patients and their caregivers: Multicentre national study results
Stress Analysis of Steel Beams Made of Sigma Cross-Section
This paper presents a stress analysis of elements made of a steel cold-formed sigma cross-section, uniformly loaded in a plane parallel to the web and not passing through the shear centre. Such an application of a load very often occurs in engineering practice and corresponds to the application of a load to the upper flange of the cross-section. It usually result in an additional torsional moment. In this paper, special attention is paid to normal stresses from the bi-moment, and shear stresses from restrained and free torsion. The contribution of these stresses to the section utilization was evaluated on the example of a sigma cross-section with different thicknesses of the wall. Furthermore, the paper also included the stresses analysis concerning different load locations at the upper flange. All numerical calculations were made using analytical approach based on Vlasov beam theory
Expression of RUNX2 and its signaling partners TCF7, FGFR1/2 in cleidocranial dysplasia
RUNX2 is a member of the PEBP2/CBF transcription factors family controlling the expression of genes whose products are essential for bone formation. Mutations in the RUNX2 gene may be associated with cleidocranial dysplasia (CCD), a rare skeletal disease characterized by stature aberrations, delayed closure of the cranial sutures, hypoplastic or aplastic clavicles, and multiple dental abnormalities. As RUNX2 is involved in many signaling pathways, we hypothesize that CCD may be associated with their changes. We determined the expression of RUNX2 and its signaling partners TCF7, involved in canonical Wnt signaling, and fibroblast growth factor receptors, FGFR1 and FGFR2 in periodontum of CCD patients and control individuals. We did not observe any differences between the level of RUNX2, TCF7 and FGFR1/2 mRNA, determined by real-time PCR, in CDD patients and controls. Therefore, RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis
Unveiling the Factors of Green Human Resources in Manufacturing Industries
The severe consequences of climate change have left many unanswered questions about the environmental performance of businesses. Appropriate measures must be taken to tackle the problems conquered due to climate change. This study supports exploring the factors needed to get the Employees Environmental Performance (EEP). It includes Green Human Resources (GHR), Green Creativity (GC) and Proactive Environmental Management (PEM). The relationship among the variables was explored in the existing literature. This study aims to test the relationship between GHR and GC. Further, it also examined the mediating role of GC and moderating role of PEM. For this purpose, data were collected from employees of manufacturing companies (automobiles, food processing, chemicals, textiles, machinery and equipment) in India. More specifically, ISO 14001-certified companies were selected. Among the different institutions, 35 are manufacturing in India. Out of 35, 24 companies agreed to conduct a survey in their company. Totally 5376 employees were considered as a population for the study. With 95% confidence interval, 400 samples were selected, and a questionnaire was distributed among them using simple random sampling. 305 (76.25%) cases finalized for further analysis. The collected data analyzed using PLS-SEM with R software. The results highlighted the essential role of GHR practices in the manufacturing industry to enhance EEP since GHR positively influences EEP. Moreover, it was found that GC partially mediates the relationship between GHR and EEP. It indicates the importance of GC鈥檚 existence in increasing EEP through GHR. Finally, it was also found that PEM moderates the relationship between GHR and EEP. It suggested the role of pro-environmental management and their active pace in improving EEP. Managerial implications and future scope were discussed in this study
Familial juvenile hyperuricemic nephropathy as rare cause of dialysis-dependent chronic kidney disease鈥攁 series of cases in two families
Optimal designs under a multivariate linear model with additional nuisance parameters
Multivariate model, Estimable function, Kiefer optimality, Information matrix, Precision matrix, 62K05, 62K10,
Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
Anxiety is a troublesome symptom for many patients, especially those suffering from schizophrenia. Its regulation involves serotonin receptors, targeted e.g. by antipsychotics or psychedelics such as LSD. 5-HT(2A) receptors are known for an extremely long LSD residence time, enabling minute doses to exert a long-lasting effect. In this work, we explore the changes in anxiety-like processes induced by the previously reported antipsychotic, D2AAK1. In vivo studies revealed that the effect of D2AAK1 on the anxiety is mediated through serotonin 5-HT(1A) and 5-HT(2A) receptors, and that it is time-dependent (anxiogenic after 30聽min, anxiolytic after 60聽min) and dose-dependent. The funnel metadynamics simulations suggest complicated ligand-5HT(2A)R interactions, involving an allosteric site located under the third extracellular loop, which is a possible explanation of the time-dependency. The binding of D2AAK1 at the allosteric site results in a broader opening of the extracellular receptor entry, possibly altering the binding kinetics of orthosteric ligands