Peran Pustakawan Dalam Pengolahan Bahan Pustaka Buku Di Badan Perpustakaan, Arsip Dan Dokumentasi Propinsi Sulawesi Utara

From the results of this study found that the capabilities, performance, and the role that librarians have fulfilled their duties and responsibilities as well as begin to be effective in performing the role of librarians. All of this happens because the librarian did not stop to start meneus continue to learn and develop themselves in the knowledge and skills although there are errors in the classification, and in analyzing the canopy pengkatalogkan subject but it can be covered with tenacity and consistent to keep learning in working in the library. Mistakes are still in process but not stop the librarian intention to continue to grow. Education and background may be different but the desire to move forward always have within themselves so that they can do their roles as librarians to meet the information needed by pemustaka

PERAN OTORITAS JASA KEUANGAN SEBAGAI PENGAWAS APLIKASI PINJAMAN ONLINE DALAM MELINDUNGI DEBITUR YANG CIDERA JANJI AKIBAT FORCE MAJEURE

Penelitian ini bertujuan untuk mengetahui peran daripada Otoritas Jasa Keuangan sebagai pengawas aplikasi pinjaman online dan perlindungan hukum apa yang diberikan oleh Otoritas Jasa Keuangan kepada debitur yang cidera janji akibat force majeure. Metode penelitian yang di gunakan dalam penulisan ini adalah metode pendekatan Yuridis Normatif, dan kesimpulan yang di dapat: 1. Peran Otoritas Jasa Keuangan dalam pengawasan aplikasi pinjaman online meliputi pendaftaran, dan lisensi Perusahaan penyelenggara fintech, verifikasi berkas, penilaian kesesuaian, dan pengawasan operasional Perusahaan; 2. Perlindungan hukum yang diberikan oleh Otoritas Jasa Keuangan bagi debitur pinjaman online yang cidera janji akibat force majeure yaitu menciptakan pengaturan Otoritas Jasa Keuangan bagi debitur-debitur yang melakukan kegiatan jasa keuangan di lingkup layanan pinjam meminjam uang berbasis teknologi informasi. Kata Kunci : Otoritas Jasa Keuangan, Pinjaman Online, Cidera Janji (Wanprestasi), Force Majeur

Perancangan Buku Pengenalan Dan Informasi Tempat Bersejarah Di Surabaya Utara

Perancangan buku ini merupakan sebuah USAha untuk meningkatkan minat wisatawan untuk mengunjungi tempat wisata dan cagar budaya melalui media buku yang berisikan informasi mengenai tempat atau bangunan yang memiliki nilai sejarah terutama yang berada di daerah Surabaya Utara. Bagaimana merancang buku yang efektif dan komunikatif sehingga target audience dapat memahami dan tertarik akan keindahan cagar budaya di Surabaya. Tujuan utama dari perancangan ini adalah mewujudkan perancangan buku yang memberikan informasi mengenai tempat-tempat bersejarah di kawasan Surabaya Utara bagi wisatawan lokal maupun wisatawan asing

Sistem Monitoring Kognitif, Afektif Dan Psikomotorik Siswa Berbasis Android

Skripsi ini berisi tentang proses pembuatan aplikasi mobile berbasis android, dimana aplikasi ini mempermudah pekerjaan para guru di sekolah dalam halmemonitoring dan mengevaluasi tiga aspek penting dalam pembelajaran para peserta didik yaitu aspek kognitif, afektif, dan psikomotorik. Aplikasi ini bertujuan untu membantu para guru dalam memonitoring ketiga aspek pembelajaran tersebut dengan cepat dan mudah dengan mengandalkan kemampuan smartphone saat ini. Metodologi yang digunakan dalam pembuatan aplikasi mobile ini adalah RAD (Rapid ApplicationDevelopment) yang meliputi empat tahap kerja yaitu analisis persyaratan, analisis modeling, desain modeling dan konstruksi.Aplikasi mobile ini diharapkan bisa menjadi solusi atas kelemahan – kelemahan yang ada pada sistem monitoring yang dipakai olehsekolah – sekolah saat ini

Dynamics of neutrophils to lymphocyte ratio (NLR) predict outcomes of PD-1/PD-L1 blockade

Introduction. Baseline neutrophil-to-lymphocyte ratio (NLR) has been repeatedly reported as a significant prognostic factor in advanced cancer patients. We explored whether changes in NLR may predict outcome of advanced cancer patients enrolled into phase 1 trials and treated with PD-1/PD-L1 inhibitors. Patients and Methods. Advanced cancer patients enrolled into phase 1 trials between September 2013 and May 2016 and treated with anti-PD-1/PD-L1 agents were included in this retrospective study. NLR was calculated at baseline and after 2 cycles of treatment. Royal Marsden Hospital (RMH) prognostic score and Eastern Cooperative Group (ECOG) performance status (PS) were determined at baseline. Kaplan-Meier estimation and Cox regression analyses were used to assess the impact of NLR dynamics on PFS. Results. Among the 55 patients eligible, 26 (47%) were treated with anti-PD-L1 monotherapy, 22 (40%) received single agent anti-PD-1, and 7 (13%) were given a tyrosine kinase inhibitor (TKI) plus a PD-1 inhibitor. Neither ECOG PS nor RMH prognostic score was significantly associated with PFS in our cohort, whereas changes in NLR significantly impacted on PFS. Conclusion. Changes in the NLR may be a useful predicting factor in advanced cancer patients treated with anti-PD-1/PD-L1 agents. Further prospective trials are needed to verify these findings

The reporting of studies using routinely collected health data was often insufficient.

OBJECTIVES: To assess reporting quality of studies using routinely collected health data (RCD) to inform the REporting of studies Conducted using Observational Routinely collected health Data (RECORD) guideline development. STUDY DESIGN AND SETTING: PubMed search for observational studies using RCD on any epidemiologic or clinical topic. Sample of studies published in 2012. Evaluation of five items based on the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) guideline and eight newly developed items for RCD studies. RESULTS: Of 124 included studies, 39 (31.5%) clearly described its design in title or abstract. Complete information to frame a focused research question, that is, on the population, intervention/exposure, and outcome, was provided for 51 studies (41.1%). In 44 studies where definitions of codes or classification algorithms would be necessary to operationalize such a research question, only nine (20.5%) reported all items adequately. In 81 studies describing multivariable analyses, 54 (66.7%) reported all variables used for modeling and 34 (42.0%) reported basic details required for replication. Database linkage was reported adequately in 12 of 41 studies (29.3%). Statements about data sharing/availability were rare (5/124; 4%). CONCLUSION: Most RCD studies are insufficiently reported. Specific reporting guidelines and more awareness and education on their use are urgently needed

Planning and reporting of quality-of-life outcomes in cancer trials

BACKGROUND Information about the impact of cancer treatments on patients' quality of life (QoL) is of paramount importance to patients and treating oncologists. Cancer trials that do not specify QoL as an outcome or fail to report collected QoL data, omit crucial information for decision making. To estimate the magnitude of these problems, we investigated how frequently QoL outcomes were specified in protocols of cancer trials and subsequently reported. DESIGN Retrospective cohort study of RCT protocols approved by six research ethics committees in Switzerland, Germany, and Canada between 2000 and 2003. We compared protocols to corresponding publications, which were identified through literature searches and investigator surveys. RESULTS Of the 173 cancer trials, 90 (52%) specified QoL outcomes in their protocol, 2 (1%) as primary and 88 (51%) as secondary outcome. Of the 173 trials, 35 (20%) reported QoL outcomes in a corresponding publication (4 modified from the protocol), 18 (10%) were published but failed to report QoL outcomes in the primary or a secondary publication, and 37 (21%) were not published at all. Of the 83 (48%) trials that did not specify QoL outcomes in their protocol, none subsequently reported QoL outcomes. Failure to report pre-specified QoL outcomes was not associated with industry sponsorship (versus non-industry), sample size, and multicentre (versus single centre) status but possibly with trial discontinuation. CONCLUSIONS About half of cancer trials specified QoL outcomes in their protocols. However, only 20% reported any QoL data in associated publications. Highly relevant information for decision making is often unavailable to patients, oncologists, and health policymaker

Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS.

OBJECTIVES: A recent individual patient data (IPD) meta-analysis suggested that patients with moderate or severe acute respiratory distress syndrome (ARDS) benefit from higher positive end-expiratory pressure (PEEP) ventilation strategies. However, thresholds for continuous variables (eg, hypoxaemia) are often arbitrary and linearity assumptions in regression approaches may not hold; the multivariable fractional polynomial interaction (MFPI) approach can address both problems. The objective of this study was to apply the MFPI approach to investigate interactions between four continuous patient baseline variables and higher versus lower PEEP on clinical outcomes. SETTING: Pooled data from three randomised trials in intensive care identified by a systematic review. PARTICIPANTS: 2299 patients with acute lung injury requiring mechanical ventilation. INTERVENTIONS: Higher (N=1136) versus lower PEEP (N=1163) ventilation strategy. OUTCOME MEASURES: Prespecified outcomes included mortality, time to death and time-to-unassisted breathing. We examined the following continuous baseline characteristics as potential effect modifiers using MFPI: PaO2/FiO2 (arterial partial oxygen pressure/ fraction of inspired oxygen), oxygenation index, respiratory system compliance (tidal volume/(inspiratory plateau pressure-PEEP)) and body mass index (BMI). RESULTS: We found that for patients with PaO2/FiO2 below 150 mm Hg, but above 100 mm Hg or an oxygenation index above 12 (moderate ARDS), higher PEEP reduces hospital mortality, but the beneficial effect appears to level off for patients with very severe ARDS. Patients with mild ARDS (PaO2/FiO2 above 200 mm Hg or an oxygenation index below 10) do not seem to benefit from higher PEEP and might even be harmed. For patients with a respiratory system compliance above 40 mL/cm H2O or patients with a BMI above 35 kg/m(2), we found a trend towards reduced mortality with higher PEEP, but there is very weak statistical confidence in these findings. CONCLUSIONS: MFPI analyses suggest a nonlinear effect modification of higher PEEP ventilation by PaO2/FiO2 and oxygenation index with reduced mortality for some patients suffering from moderate ARDS. STUDY REGISTRATION NUMBER: CRD42012003129