Impulse Generation by an Open Shock Tube

We perform experimental and numerical studies of a shock tube with an open end. The purpose is to investigate the impulse due to the exhaust of gases through the open end of the tube as a model for a partially filled detonation tube as used in pulse detonation engine testing. We study the effects of the pressure ratio (varied from 3 to 9.2) and the volume ratio (expressed as fill fractions) between the driver and driven section. Two different driver gases, helium and nitrogen, and fill fractions between 5 and 100% are studied; the driven section is filled with air. For both driver gases, increasing the pressure ratio leads to larger specific impulses. The specific impulse increases for a decreasing fill fraction for the helium driver, but the impulse is almost independent of the fill fraction for the nitrogen driver. Two-dimensional (axisymmetric) numerical simulations are carried out for both driver gases. The simulation results show reasonable agreement with experimental measurements at high pressure ratios or small fill fractions, but there are substantial discrepancies for the smallest pressure ratios studied. Empirical models for the impulse in the limits of large and small fill fractions are also compared with the data. Reasonable agreement is found for the trends with fill fractions using the Gurney or Sato model at large fill fractions, but only Cooper’s bubble model is able to predict the small fill fraction limit. Computations of acoustic impedance and numerical simulations of unsteady gas dynamics indicate that the interaction of waves with the driver-driven gas interface and the propagation of waves in the driven gas play an essential role in the partial-fill effect

Composition of primary cosmic rays at energies 10(15) to approximately 10(16) eV

The sigma epsilon gamma spectrum in 1 approx. 5 x 1000 TV observed at Mt. Fuji suggests that the flux of primary protons 10 to the 15 approx 10th eV is lower by a factor of 2 approx. 3 than a simple extrapolation from lower energies; the integral proton spectrum tends to be steeper than around to the power V and the spectral index tends to be steeper than Epsilon to the -17th power around 10 to the 14th power eV and the spectral index becomes approx. 2.0 around 10 to the 15th power eV. If the total flux of primary particles has no steepening up to approx 10 to the 15th power eV, than the fraction of primary protons to the total flux should be approx 20% in contrast to approx 45% at lower energies

High energy gamma-rays and hadrons at Mount Fuji

The energy spectra of high energy gamma-rays and hadrons were obtained by the emulsion chamber with 40 c.u. thickness at Mt. Fuji (3750 m). These results are compared with the Monte Carlo calculation based on the same model which is used in a family analysis. Our data are compatible with the model of heavy-enriched primary and scaling in the fragmentation region

Particle interactions at energies over 1000 TeV inferred from gamma-families observed at Mount Fuji

Scaling, mean P sub t, high P sub t jets and others at energies over 1000 TeV are discussed on the basis of gamma-family data with sigma E sub gamma 100 TeV, observed at Mt. Fuji (3750 m). These quantities were examined in connection with the primary composition

Line nodes in the superconducting gap function of noncentrosymmetric CePt_3Si

The superconducting gap structure of recently discovered heavy fermion CePt_3Si without spatial inversion symmetry was investigated by thermal transport measurements down to 40 mK. In zero field a residual T-linear term was clearly resolved as T-> 0, with a magnitude in good agreement with the value expected for a residual normal fluid with a nodal gap structure, together with a T^2-dependence at high temperatures. With an applied magnetic fields, the thermal conductivity grows rapidly, in dramatic contrast to fully gapped superconductors, and exhibits one-parameter scaling with T/sqrt{H}. These results place an important constraint on the order parameter symmetry, that is CePt_3Si is most likely to have line nodes.Comment: 5pages, 3figures, accpted for publication in Phys. Rev. Let

Anisotropic Superconducting Properties of Optimally Doped BaFe2_2(As0.65_{0.65}P0.35_{0.35})2_2 under Pressure

Magnetic measurements on optimally doped single crystals of BaFe$_2$(As$_{1-x}$P$_{x}$)$_2$ ($x\approx0.35$) with magnetic fields applied along different crystallographic axes were performed under pressure, enabling the pressure evolution of coherence lengths and the anisotropy factor to be followed. Despite a decrease in the superconducting critical temperature, our studies reveal that the superconducting properties become more anisotropic under pressure. With appropriate scaling, we directly compare these properties with the values obtained for BaFe$_2$(As$_{1-x}$P$_{x}$)$_2$ as a function of phosphorus content.Comment: 5 pages, 3 figure

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model.

BackgroundToca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5-fluorouracil (5-FU). This therapeutic approach is being tested in a randomized phase II/III trial in recurrent glioblastoma and anaplastic astrocytoma (NCT0241416). The aim of this study was to identify the immune cell subsets contributing to antitumor immune responses following treatment with 5-FC in Toca 511-expressing gliomas in a syngeneic mouse model.MethodsFlow cytometry was utilized to monitor and characterize the immune cell infiltrate in subcutaneous Tu-2449 gliomas in B6C3F1 mice treated with Toca 511 and 5-FC.ResultsTumor-bearing animals treated with Toca 511 and 5-FC display alterations in immune cell populations within the tumor that result in antitumor immune protection. Attenuated immune subsets were exclusive to immunosuppressive cells of myeloid origin. Depletion of immunosuppressive cells temporally preceded a second event which included expansion of T cells which were polarized away from Th2 and Th17 in the CD4+ T cell compartment with concomitant expansion of interferon gamma-expressing CD8+ T cells. Immune alterations correlated with clearance of Tu-2449 subcutaneous tumors and T cell-dependent protection from future tumor challenge.ConclusionsTreatment with Toca 511 and 5-FC has a concentrated effect at the site of the tumor which causes direct tumor cell death and alterations in immune cell infiltrate, resulting in a tumor microenvironment that is more permissive to establishment of a T cell mediated antitumor immune response

Coexistence of orbital and quantum critical magnetoresistance in FeSe1−x_{1-x}Sx_{x}

The recent discovery of a non-magnetic nematic quantum critical point (QCP) in the iron chalcogenide family FeSe$_{1-x}$S$_{x}$ has raised the prospect of investigating, in isolation, the role of nematicity on the electronic properties of correlated metals. Here we report a detailed study of the normal state transverse magnetoresistance (MR) in FeSe$_{1-x}$S$_{x}$ for a series of S concentrations spanning the nematic QCP. For all temperatures and \textit{x}-values studied, the MR can be decomposed into two distinct components: one that varies quadratically in magnetic field strength $\mu_{0}\textit{H}$ and one that follows precisely the quadrature scaling form recently reported in metals at or close to a QCP and characterized by a \textit{H}-linear MR over an extended field range. The two components evolve systematically with both temperature and S-substitution in a manner that is determined by their proximity to the nematic QCP. This study thus reveals unambiguously the coexistence of two independent charge sectors in a quantum critical system. Moreover, the quantum critical component of the MR is found to be less sensitive to disorder than the quadratic (orbital) MR, suggesting that detection of the latter in previous MR studies of metals near a QCP may have been obscured.Comment: 19 pages (including Supplemental Material), 12 figure

Low temperature specific heat of La_{3}Pd_{4}Ge_{4} with U_{3}Ni_{4}Si_{4}-type structure

Low temperature specific heat has been investigated in a novel ternary superconductor La_{3}Pd_{4}Ge_{4} with an U_{3}Ni_{4}Si_{4}-type structure consisting of the alternating BaAl_{4} (ThCr_{2}Si_{2})- and AlB$_{2}$-type layers. A comparative study with the related ThCr_{2}Si_{2}-type superconductor LaPd_{2}Ge_{2}, one of the layers in La_{3}Pd_{4}Ge_{4}, is also presented. From the normal state specific heat, the Sommerfeld coefficient $\gamma_{n} = 27.0$ mJ/mol K^2 and the Debye temperature $\Theta_{\rm D}$ = 256 K are derived for the La_{3}Pd_{4}Ge_{4}, while those for the LaPd_{2}Ge_{2} are $\gamma_{n} =8.26$ mJ/mol K^2 and $\Theta_{\rm D}$ = 291 K. The La_{3}Pd_{4}Ge_{4} has moderately high electronic density of state at the Fermi level. Electronic contribution on the specific heat, $C_{\rm el}$, in each compound is well described by the BCS behavior, suggesting that both of the La_{3}Pd_{4}Ge_{4} and the LaPd_{2}Ge_{2} have fully opened isotropic gap in the superconducting state