398 research outputs found
The Onset of Phase Transitions in Condensed Matter and Relativistic QFT
Kibble and Zurek have provided a unifying causal picture for the appearance
of topological defects like cosmic strings or vortices at the onset of phase
transitions in relativistic QFT and condensed matter systems respectively.
There is no direct experimental evidence in QFT, but in condensed matter the
predictions are largely, but not wholly, supported in superfluid experiments on
liquid helium. We provide an alternative picture for the initial appearance of
strings/vortices that is commensurate with all the experimental evidence from
condensed matter and consider some of its implications for QFT.Comment: 37 pages, to be published in Condensed Matter Physics, 200
Development of three dimensional constitutive theories based on lower dimensional experimental data
Most three dimensional constitutive relations that have been developed to
describe the behavior of bodies are correlated against one dimensional and two
dimensional experiments. What is usually lost sight of is the fact that
infinity of such three dimensional models may be able to explain these
experiments that are lower dimensional. Recently, the notion of maximization of
the rate of entropy production has been used to obtain constitutive relations
based on the choice of the stored energy and rate of entropy production, etc.
In this paper we show different choices for the manner in which the body stores
energy and dissipates energy and satisfies the requirement of maximization of
the rate of entropy production that leads to many three dimensional models. All
of these models, in one dimension, reduce to the model proposed by Burgers to
describe the viscoelastic behavior of bodies.Comment: 23 pages, 6 figure
Slow Quenches Produce Fuzzy, Transient Vortices
We examine the Zurek scenario for the production of vortices in quenches of
liquid in the light of recent experiments. Extending our previous
results to later times, we argue that short wavelength thermal fluctuations
make vortices poorly defined until after the transition has occurred. Further,
if and when vortices appear, it is plausible that that they will decay faster
than anticipated from turbulence experiments, irrespective of quench rates.Comment: 4 pages, Revtex file, no figures Apart from a more appropriate title,
this paper differs from its predecessor by including temperature, as well as
pressure, quenche
A thermodynamic framework to develop rate-type models for fluids without instantaneous elasticity
In this paper, we apply the thermodynamic framework recently put into place
by Rajagopal and co-workers, to develop rate-type models for viscoelastic
fluids which do not possess instantaneous elasticity. To illustrate the
capabilities of such models we make a specific choice for the specific
Helmholtz potential and the rate of dissipation and consider the creep and
stress relaxation response associated with the model. Given specific forms for
the Helmholtz potential and the rate of dissipation, the rate of dissipation is
maximized with the constraint that the difference between the stress power and
the rate of change of Helmholtz potential is equal to the rate of dissipation
and any other constraint that may be applicable such as incompressibility. We
show that the model that is developed exhibits fluid-like characteristics and
is incapable of instantaneous elastic response. It also includes Maxwell-like
and Kelvin-Voigt-like viscoelastic materials (when certain material moduli take
special values).Comment: 18 pages, 5 figure
Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize.
Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing radiation (IR). In theory, more potent radiosensitizing drugs should increase tumour kill and improve patient outcomes. In practice, clinical utility of potent radiosensitizing drugs is curtailed by off-target side effects. Here we report potent anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize to tumours based on surface receptor expression. While two classes of potent anti-tubulins, auristatins and maytansinoids, indiscriminately radiosensitize tumour cells, conjugating these potent anti-tubulins to anti-ErbB antibodies restrict their radiosensitizing capacity. Of translational significance, we report that a clinically used maytansinoid ADC, ado-trastuzumab emtansine (T-DM1), with IR prolongs tumour control in target expressing HER2+ tumours but not target negative tumours. In contrast to ErbB signal inhibition, our findings establish an alternative therapeutic paradigm for ErbB-based radiosensitization using antibodies to restrict radiosensitizer delivery
Dynamics of defect formation
A dynamic symmetry-breaking transition with noise and inertia is analyzed.
Exact solution of the linearized equation that describes the critical region
allows precise calculation (exponent and prefactor) of the number of defects
produced as a function of the rate of increase of the critical parameter. The
procedure is valid in both the overdamped and underdamped limits. In one space
dimension, we perform quantitative comparison with numerical simulations of the
nonlinear nonautonomous stochastic partial differential equation and report on
signatures of underdamped dynamics.Comment: 4 pages, LaTeX, 4 figures. Submitted to Physical Revie
How Phase Transitions induce classical behaviour
We continue the analysis of the onset of classical behaviour in a scalar
field after a continuous phase transition, in which the system-field, the long
wavelength order parameter of the model, interacts with an environment, of its
own short-wavelength modes and other fields, neutral and charged, with which it
is expected to interact. We compute the decoherence time for the system-field
modes from the master equation and directly from the decoherence functional
(with identical results). In simple circumstances the order parameter field is
classical by the time the transition is complete.Comment: 10 pages, 1 figure: To be published in the International Journal of
Theoretical Physics (2005) as part of the Proceedings of the "Peyresq Physics
9" meeting (2004) on "Micro and Macro structures of spacetime",ed. E.
Verdague
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