513 research outputs found
Finite element analysis of a fluid-structure interaction in flexible pipe line
This paper describes the basic theory and computing method for transient flow of liquid in flexible pipe such as rubber tubing and arterial system. A mathematical model taking into account tube wall axial and radial motion (in which the dynamic fluid pressure causes circumferential and axial motion of the tube wall) is presented. The tube wall is assumed to be elastic material and the compressibility of the liquid is neglected. Circumferential and axial strain-stress relationships for the tube are considered. The obtained mathematical system is constituted of four non-linear hyperbolic partial differential equations describing the wave propagation in both pipe wall and liquid flow. The fluid-structure interaction is found to be governed by Poisson’s ratio. In this steady finite element method based on Galerkin formulation is applied. Numerical results show a good similarity with those of the literature obtained by the characteristics method.Key words : Fluid-structure interaction, flexible pipe, rubber, finite element method
Slow Quenches Produce Fuzzy, Transient Vortices
We examine the Zurek scenario for the production of vortices in quenches of
liquid in the light of recent experiments. Extending our previous
results to later times, we argue that short wavelength thermal fluctuations
make vortices poorly defined until after the transition has occurred. Further,
if and when vortices appear, it is plausible that that they will decay faster
than anticipated from turbulence experiments, irrespective of quench rates.Comment: 4 pages, Revtex file, no figures Apart from a more appropriate title,
this paper differs from its predecessor by including temperature, as well as
pressure, quenche
A thermodynamic framework to develop rate-type models for fluids without instantaneous elasticity
In this paper, we apply the thermodynamic framework recently put into place
by Rajagopal and co-workers, to develop rate-type models for viscoelastic
fluids which do not possess instantaneous elasticity. To illustrate the
capabilities of such models we make a specific choice for the specific
Helmholtz potential and the rate of dissipation and consider the creep and
stress relaxation response associated with the model. Given specific forms for
the Helmholtz potential and the rate of dissipation, the rate of dissipation is
maximized with the constraint that the difference between the stress power and
the rate of change of Helmholtz potential is equal to the rate of dissipation
and any other constraint that may be applicable such as incompressibility. We
show that the model that is developed exhibits fluid-like characteristics and
is incapable of instantaneous elastic response. It also includes Maxwell-like
and Kelvin-Voigt-like viscoelastic materials (when certain material moduli take
special values).Comment: 18 pages, 5 figure
Dynamics of defect formation
A dynamic symmetry-breaking transition with noise and inertia is analyzed.
Exact solution of the linearized equation that describes the critical region
allows precise calculation (exponent and prefactor) of the number of defects
produced as a function of the rate of increase of the critical parameter. The
procedure is valid in both the overdamped and underdamped limits. In one space
dimension, we perform quantitative comparison with numerical simulations of the
nonlinear nonautonomous stochastic partial differential equation and report on
signatures of underdamped dynamics.Comment: 4 pages, LaTeX, 4 figures. Submitted to Physical Revie
Electromagnetic response of a static vortex line in a type-II superconductor : a microscopic study
The electromagnetic response of a pinned Abrikosov fluxoid is examined in the
framework of the Bogoliubov-de Gennes formalism. The matrix elements and the
selection rules for both the single photon (emission - absorption) and two
photon (Raman scattering) processes are obtained. The results reveal striking
asymmetries: light absorption by quasiparticle pair creation or single
quasiparticle scattering can occur only if the handedness of the incident
radiation is opposite to that of the vortex core states. We show how these
effects will lead to nonreciprocal circular birefringence, and also predict
structure in the frequency dependence of conductivity and in the differential
cross section of the Raman scattering.Comment: 14 pages (RevTex
Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize.
Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing radiation (IR). In theory, more potent radiosensitizing drugs should increase tumour kill and improve patient outcomes. In practice, clinical utility of potent radiosensitizing drugs is curtailed by off-target side effects. Here we report potent anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize to tumours based on surface receptor expression. While two classes of potent anti-tubulins, auristatins and maytansinoids, indiscriminately radiosensitize tumour cells, conjugating these potent anti-tubulins to anti-ErbB antibodies restrict their radiosensitizing capacity. Of translational significance, we report that a clinically used maytansinoid ADC, ado-trastuzumab emtansine (T-DM1), with IR prolongs tumour control in target expressing HER2+ tumours but not target negative tumours. In contrast to ErbB signal inhibition, our findings establish an alternative therapeutic paradigm for ErbB-based radiosensitization using antibodies to restrict radiosensitizer delivery
Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice
Background
Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely regulated by nutrients and leptin. Nnat pre-mRNA is differentially spliced to create Nnat-α and -β isoforms. Genetic variation of NNAT is associated with severe obesity. Currently, little is known about the long-term regulation of Nnat.
Methods
Expression of Nnat isoforms were examined in the hypothalamus of mice in response to acute fast/feed, chronic caloric restriction, diet-induced obesity and modified gastric bypass surgery. Nnat expression was assessed in the central nervous system and gastrointestinal tissues. RTqPCR was used to determine isoform-specific expression of Nnat mRNA.
Results
Hypothalamic expression of both Nnat isoforms was comparably decreased by overnight and 24-h fasting. Nnat expression was unaltered in diet-induced obesity, or subsequent switch to a calorie restricted diet. Nnat isoforms showed differential expression in the hypothalamus but not brainstem after bypass surgery. Hypothalamic Nnat-β expression was significantly reduced after bypass compared with sham surgery (P = 0.003), and was positively correlated with post-operative weight-loss (R2 = 0.38, P = 0.01). In contrast, Nnat-α expression was not suppressed after bypass surgery (P = 0.19), and expression did not correlate with reduction in weight after surgery (R2 = 0.06, P = 0.34). Hypothalamic expression of Nnat-β correlated weakly with circulating leptin, but neither isoform correlated with fasting gut hormone levels post- surgery. Nnat expression was detected in brainstem, brown-adipose tissue, stomach and small intestine.
Conclusions
Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction. While Nnat isoforms in the hypothalamus are co-ordinately regulated by acute nutrient supply, after modified gastric bypass surgery Nnat isoforms show differential expression. These results raise the possibility that in the radically altered nutrient and hormonal milieu created by bypass surgery, resultant differential splicing of Nnat pre-mRNA may contribute to weight-loss
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