Phenolic composition, antioxidant capacity of Salvia verticcilata and effect on multidrug resistant bacteria by flow-cytometry

Background: Antioxidants are of great importance for preventing oxidative stress that may cause several degenerative diseases. Studies have indicated phytochemicals have high free-radical scavenging activity, which helps to reduce the risk of chronic diseases. The aim of the present study is the determination of antioxidant properties, polyphenolic content and multidrug resistant bacteria of Salvia verticcilata L.Materials and Methods: Methanol was used as the extraction solvent. The total phenolic content was calculated using Folin-Ciocalteau method and phenolic composition was determined by HPLC. The radical scavenging activity of plant was evaluated in vitro based on the reduction of the stable DPPH free radical. The reducing capacity was identified by using the FRAP method. The ability of Salvia verticcilata L. to increase the permeability of multidrug resistant bacterial cells was conducted by flow cytometric assay on Listeria innocua and E-coli.Results: The amount of total phenolics was found to be 347.5 mg GA/g extract. The IC50 value and FRAP assay are 0.61, and 0.944 respectively, Free radical scavenging effect and FRAP values are less than synthetic antioxidant compounds (BHA and BHT). Eight phenolic compounds were found in Salvia verticcilata L. Intense concentration of S. verticcilata L. has destroyed 97 % of living cells for Listeria innocua and 94.86% for E-coliConclusion: This studyshows that methanolic extracts of Salvia verticcilata L. is a potential source of natural antioxidants and antimicrobial agent and can form the basis for pharmacological studies.Key words: Salvia verticcilata, medicinal plant, antioxidant, phenolic composition, multidrug resistan

Preliminary estimation of rock mass strength using diamond bit drilling operational parameters

In many mining engineering applications such as prospecting, development, production and grouting, diamond bit drilling is widely used due to high penetration rate, core recovery and its ability to drill with less deviation. It has been well known that the operational parameters of diamond bit drilling are closely related with rock mass strength properties. One of the most widely discussed subjects in drilling is the possibility of using diamond drill bit operational parameters for preliminary estimation of rock mass strength and deformability properties used in many mining engineering design projects. Once such rock properties are estimated, it will be possible to make tactical planning decisions as mining progresses. In this study two different techniques, multiple regression and adaptive neuro-fuzzy inference system (ANFIS) were used to develop the models for preliminary estimation of rock mass strength. The variables used in the models are widely known and recorded operational parameters of diamond bit drilling such as bit load, bit rotation and penetration rate. To develop the models, a database covering the rock properties and the machine operational parameters collected from seven different drill holes in Turkey was constructed. Results indicate that both regression and ANFIS-based models can successfully be used to predict the rock mass strength. Adaptive neuro-fuzzy inference model exhibits better performance according to statistical performance indicators. By means of the developed models it is possible to estimate the strength of rock mass during drilling operation, especially in weak and highly fractured rock masses. The estimated strength parameters can be related to further mining engineering applications such as the assessment of excavatability, blast design and even mine design studies

Histopathologic evaluation of prophylactic effects of zofenopril, enalapril and valsartan against doxorubicin cardiotoxicity in rats

World Congress of Cardiology -- MAY 18-21, 2008 -- Buenos Aires, ARGENTINAWOS: 000259224800846…World Heart Federat, Argentine Soc Cardiol, Argentine Federat Cardio

A rippability classification system for marls in lignite mines

This paper describes the development of a rippability classification system for marls in lignites mines based on direct ripping runs, specific energy concept and indirect rippability assessment methods. Extensive field and laboratory studies were undertaken in six different panels of Turkish Coal Enterprises and Sivas-Kangal Lignite mines. Rock mass descriptions were made, seismic P-wave velocities are measured at the field, direct cutting tests and rock material property determination tests were carried out in the laboratory. The proposed method includes rock parameters such as uniaxial compressive strength, seismic P-wave velocity, discontinuity spacing and Schmidt hammer hardness value. In the developed method, rock properties are graded separately and rippability classes of rocks are determined according to the final grade. Appropriate dozer types and their productions are also proposed. Hence, both main components of rippability, rock and equipment properties are satisfied in the proposed system

Dysfonction diastolique du ventricule gauche: de la physiopathologie au traitement. [Diastolic dysfunction of the left ventricle: from physiopathology to treatment]

Our understanding of cardiac failure has greatly changed over the last 15 years. Left ventricular diastolic dysfunction, which is now recognised as one of the primary causes of certain types of cardiac failure (1). Abnormal left ventricular diastolic function is the common determinant and indeed the earliest sign of all chronic left ventricular failures whether systolic left ventricular dysfunction is associated with it or not (2). In this paper, we review the basis of diastolic dysfunction and its impact on diagnosis and treatment of cardiac failure