Performance Characterization of a Solenoid-type Gas Valve for the H−H^{-} Magnetron Source at FNAL

The magnetron-style $H^{-}$ ion sources currently in operation at Fermilab use piezoelectric gas valves to function. This kind of gas valve is sensitive to small changes in ambient temperature, which affect the stability and performance of the ion source. This motivates the need to find an alternative way of feeding H2 gas into the source. A solenoid-type gas valve has been characterized in a dedicated off-line test stand to assess the feasibility of its use in the operational ion sources. $H^{-}$ ion beams have been extracted at 35 keV using this valve. In this study, the performance of the solenoid gas valve has been characterized measuring the beam current output of the magnetron source with respect to the voltage and pulse width of the signal applied to the gas valve.Comment: 4 pp. arXiv admin note: text overlap with arXiv:1701.0175

Ceramic and coating applications in the hostile environment of a high temperature hypersonic wind tunnel

A Mach 7, blowdown wind tunnel was used to investigate aerothermal structural phenomena on large to full scale high speed vehicle components. The high energy test medium, which provided a true temperature simulation of hypersonic flow at 24 to 40 km altitude, was generated by the combustion of methane with air at high pressures. Since the wind tunnel, as well as the models, must be protected from thermally induced damage, ceramics and coatings were used extensively. Coatings were used both to protect various wind tunnel components and to improve the quality of the test stream. Planned modifications for the wind tunnel included more extensive use of ceramics in order to minimize the number of active cooling systems and thus minimize the inherent operational unreliability and cost that accompanies such systems. Use of nonintrusive data acquisition techniques, such as infrared radiometry, allowed more widespread use of ceramics for models to be tested in high energy wind tunnels

Implementation of Design Changes Towards a More Reliable, Hands-off Magnetron Ion Source

As the main $H^{-}$ ion source for the accelerator complex, magnetron ion sources have been used at Fermilab since the 1970s. At the offline test stand, new R&D is carried out to develop and upgrade the present magnetron-type sources of $H^{-}$ ions of up to 80 mA and 35 keV beam energy in the context of the Proton Improvement Plan. The aim of this plan is to provide high-power proton beams for the experiments at FNAL. In order to reduce the amount of tuning and monitoring of these ion sources, a new electronic system consisting of a current-regulated arc discharge modulator allow the ion source to run at a constant arc current for improved beam output and operation. A solenoid-type gas valve feeds $H_{2}$ gas into the source precisely and independently of ambient temperature. This summary will cover several studies and design changes that have been tested and will eventually be implemented on the operational magnetron sources at Fermilab. Innovative results for this type of ion source include cathode geometries, solenoid gas valves, current controlled arc pulser, cesium boiler redesign, gas mixtures of hydrogen and nitrogen, and duty factor reduction, with the aim to improve source lifetime, stability, and reducing the amount of tuning needed. In this summary, I will highlight the advances made in ion sources at Fermilab and will outline the directions of the continuing R&D effort.Comment: 4 pp. arXiv admin note: substantial text overlap with arXiv:1701.0175

Improvements on the Stability and Operation of a Magnetron H- Ion Source

The magnetron H- ion sources developed in the 1970s currently in operation at Fermilab provide beam to the rest of the accelerator complex. A series of modifications to these sources have been tested in a dedicated offline test stand with the aim of improving different operational issues. The solenoid type gas valve was tested as an alternative to the piezoelectric gas valve in order to avoid its temperature dependence. A new cesium oven was designed and tested in order to avoid glass pieces that were present with the previous oven, improve thermal insulation and fine tune its temperature. A current-regulated arc modulator was developed to run the ion source at a constant arc current, providing very stable beam outputs during operations. In order to reduce beam noise, the addition of small amounts of N2 gas was explored, as well as testing different cathode shapes with increasing plasma volume. This paper summarizes the studies and modifications done in the source over the last three years with the aim of improving its stability, reliability and overall performance.Comment: 8 pages, 19 figure

Recent Operation of the FNAL Magnetron H−H^{-} Ion Source

This paper will detail changes in the operational paradigm of the Fermi National Accelerator Laboratory (FNAL) magnetron $H^{-}$ ion source due to upgrades in the accelerator system. Prior to November of 2012 the $H^{-}$ ions for High Energy Physics (HEP) experiments were extracted at ~18 keV vertically downward into a 90 degree bending magnet and accelerated through a Cockcroft-Walton accelerating column to 750 keV. Following the upgrade in the fall of 2012 the $H^{-}$ ions are now directly extracted from a magnetron at 35 keV and accelerated to 750 keV by a Radio Frequency Quadrupole (RFQ). This change in extraction energy as well as the orientation of the ion source required not only a redesign of the ion source, but an updated understanding of its operation at these new values. Discussed in detail are the changes to the ion source timing, arc discharge current, hydrogen gas pressure, and cesium delivery system that were needed to maintain consistent operation at >99% uptime for HEP, with an increased ion source lifetime of over 9 months.Comment: 8 p

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

© 2019, The Author(s). Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNFα and anti-α 4 β 7 integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation. Volume 4: System models and data analysis

In this volume, volume 4 (of five volumes), the discussion is focussed on the system models and related data references and has the following subsections: space shuttle main engine, integrated solid rocket booster, orbiter auxiliary power units/hydraulics, and electrical power system

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation, volume 1

This document is the Executive Summary of a technical report on a probabilistic risk assessment (PRA) of the Space Shuttle vehicle performed under the sponsorship of the Office of Space Flight of the US National Aeronautics and Space Administration. It briefly summarizes the methodology and results of the Shuttle PRA. The primary objective of this project was to support management and engineering decision-making with respect to the Shuttle program by producing (1) a quantitative probabilistic risk model of the Space Shuttle during flight, (2) a quantitative assessment of in-flight safety risk, (3) an identification and prioritization of the design and operations that principally contribute to in-flight safety risk, and (4) a mechanism for risk-based evaluation proposed modifications to the Shuttle System. Secondary objectives were to provide a vehicle for introducing and transferring PRA technology to the NASA community, and to demonstrate the value of PRA by applying it beneficially to a real program of great international importance

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation. Volume 5: Auxiliary shuttle risk analyses

Volume 5 is Appendix C, Auxiliary Shuttle Risk Analyses, and contains the following reports: Probabilistic Risk Assessment of Space Shuttle Phase 1 - Space Shuttle Catastrophic Failure Frequency Final Report; Risk Analysis Applied to the Space Shuttle Main Engine - Demonstration Project for the Main Combustion Chamber Risk Assessment; An Investigation of the Risk Implications of Space Shuttle Solid Rocket Booster Chamber Pressure Excursions; Safety of the Thermal Protection System of the Space Shuttle Orbiter - Quantitative Analysis and Organizational Factors; Space Shuttle Main Propulsion Pressurization System Probabilistic Risk Assessment, Final Report; and Space Shuttle Probabilistic Risk Assessment Proof-of-Concept Study - Auxiliary Power Unit and Hydraulic Power Unit Analysis Report

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation. Volume 2: Integrated loss of vehicle model

The application of the probabilistic risk assessment methodology to a Space Shuttle environment, particularly to the potential of losing the Shuttle during nominal operation is addressed. The different related concerns are identified and combined to determine overall program risks. A fault tree model is used to allocate system probabilities to the subsystem level. The loss of the vehicle due to failure to contain energetic gas and debris, to maintain proper propulsion and configuration is analyzed, along with the loss due to Orbiter, external tank failure, and landing failure or error