In situ decoration of Au NPs over polydopamine encapsulated GO/Fe3O4 nanoparticles as a recyclable nanocatalyst for the reduction of nitroarenes

Abstract A new and efficient catalyst has been designed and prepared via in situ immobilization of Au NPs fabricated polydopamine (PDA)-shelled Fe3O4 nanoparticle anchored over graphene oxide (GO) (GO/Fe3O4@PDA/Au). This novel, architecturally interesting magnetic nanocomposite was fully characterized using different analytical techniques such as Field Emission Scanning Electron Microscopy, Energy Dispersive X-ray Spectroscopy, elemental mapping, Transmission Electron Microscopy, Fourier Transformed Infrared Spectroscopy, X-ray Diffraction and Inductively Coupled Plasma-Atomic Electron Spectroscopy. Catalytic activity of this material was successfully explored in the reduction of nitroarenes to their corresponding substituted anilines, using NaBH4 as reducing agent at ambient conditions. The most significant merits for this protocol were smooth and clean catalysis at room temperature with excellent productivity, sustainable conditions, ease of separation of catalyst from the reaction mixture by using a magnetic bar and most importantly reusability of the catalyst at least 8 times without any pre-activation, minimum loss of activity and considerable leaching

Panax ginseng leaf aqueous extract mediated green synthesis of AgNPs under ultrasound condition and investigation of its anti-lung adenocarcinoma effects

Panax ginseng has many therapeutic uses in medicine. In the recent research, silver nanoparticles (AgNPs) were formulated by the Panax ginseng aqueous extract. The synthesized AgNPs’ characterization was analyzed using UV-Vis spectrophotometry, energy dispersive X-ray spectroscopy, scanning electron microscopy, fourier transformed infrared spectroscopy, transmission electron microscopy, and elemental mapping. The AgNPs were analyzed for their surface morphology by SEM. The successful synthesis of AgNPs was evident with TEM images. The AgNPs had a uniform distribution and homogenous spherical shaped morphology with mean diameter in the range of 20–30 nm. The cytotoxic and anti-lung adenocarcinoma ‎potentials of biologically formulated AgNPs‎ against NCI-H1563‎, NCI-H1437‎, NCI-H1299‎, and NCI-H2126 cells were determined. The anti-lung adenocarcinoma ‎ properties of the AgNPs ‎ removed NCI-H1563‎, NCI-H1437‎, NCI-H1299‎, and NCI-H2126 cells. The AgNPs’ IC50‎ were 193, 156, 250, and 278 µg/mL against NCI-H1563‎, NCI-H1437‎, NCI-H1299‎, and NCI-H2126 cells, respectively. Also, AgNPs presented high antioxidant potential

Treatment of gastric cancer by green mediated silver nanoparticles using Pistacia atlantica bark aqueous extract

We herein demonstrate a novel green mediated silver nanoparticles (AgNPs) using Pistacia atlantica bark aqueous extract for the treatment of gastric cancer under in vitro conditions. Physicochemical and structural features of the nanocomposite biomaterial were assessed by several techniques like UV-Vis spectrum, transmission electron spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and inductively coupled plasma-optical emission spectroscopy. The Ag NPs showed high antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH). The IC50 of Ag NPs and Butylated hydroxytoluene against DPPH were 132 and 77 µg/mL, respectively. In the oncological part of this research, the status of normal and gastric cancer AGS and KATO III cell lines was determined. The IC50 of AgNPs was 193 and 250 µg/mL against AGS and KATO III. It seems that the prepared NP have stopped the growth of gastric cancer cells and the recent cancer cells have been removed with high concentration of NPs

Green synthesis of Ag/Fe3O4 nanoparticles using Mentha longifolia flower extract: evaluation of its antioxidant and anti-lung cancer effects

Herein, a bio-inspired synthetic method for Ag NP adorned biofunctionalized magnetic nanocomposite has been demonstrated. In the procedure, Mentha longifolia flower extract was employed as a template for the green reduction of immobilized Ag ions to corresponding NPs and subsequent stabilization. The phytochemical modification also facilitated the Fe3O4 NPs to protect from self-aggregation. The as-synthesized Ag/Fe3O4 nanocomposite material was characterized by SEM, TEM, EDX, elemental mapping, VSM, XRD and ICP-OES methods. Towards the biological application, the material was first explored in the anti-oxidant study following DPPH assay and it exhibited a significant radical scavenging capacity. The application of Ag/Fe3O4 nanocomposite was further progressed in the anticancer study against standard human lung cancer cell lines (A549 and H358). Cytotoxicity of the material against the cell lines were determined in terms of % cell viability following MTT method and was found to decrease with increase in the material load

Sonochemical synthesis of gold nanoparticles mediated by potato starch: Its performance in the treatment of esophageal cancer

Economically viable and eco-friendly potato starch (PS) was employed to synthesize Au NPs under ultrasound irradiation. PS phytochemicals have the function of a green reductant as well as an efficient stabilizer template to cap and synthesize gold nanoparticles. Transmission electron microscopy (TEM), UV-Vis spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) were applied to investigate the structure of the synthesized PS-Au NPs nanocomposite. FESEM results showed that the obtained Au NPs were spherical and ∼30 nm in diameter; their crystalline nature was detected by XRD and TEM data. PS-Au NP nanocomposite shows high antioxidant effects against DPPH. The colorimetric MTT investigation was followed in the determination of anti-esophageal cancer properties of the PS-Au NP nanocomposite against KYSE-30 and FLO-1 cell lines. The findings indicate that in 3 days, the cancer cell survival percentage in various dilations reduced as much as the PS-Au NP nanocomposite concentration increased. The best anti-cancer effect of the PS-Au NP nanocomposite was reported at 1,000 μg/mL dilation. Through MTT cytotoxicity analysis the half-maximal inhibitory concentration of PS-Au nanocomposite or IC50 values against the KYSE-30 and FLO-1 esophageal carcinoma cells were found as 125 and 176 μg/mL, respectively. The data indicated that these PS-Au NP nanocomposites inhibited esophageal cancer cells more strongly than normal cells

Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug

In this research article we have demonstrated the sustainable green synthesis of a novel starch templated CuO NP following a clean and non-hazardous pathway. Ultrasonic irradiation was used to promote the reaction in alkaline medium. The numerous hydroxyl groups present in starch was exploited in the green reduction of immobilized copper ions in situ. They also helped to stabilize the as synthesized Cu NPs by encapsulation or capping. The morphology and physicochemical characteristics were ascertained over an array of analytical techniques like Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDS), Elemental Mapping, Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), and Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES). Biologically, the nanocomposite exhibited excellent cytotoxicity against human renal cell carcinoma (RCC-GH, CaKi-2 and HEK293) cell lines without affecting the normal (HUVEC) cell line. IC50 values of the nanocomposite were found at 139, 208and 125 against RCC-GH, CaKi-2 and HEK293 cell lines respectively and accordingly, HEK293 afforded the best adenocarcinoma activity