Mixed CO2-Water Injection Into Geothermal Reservoirs: A Numerical Study

ABSTRACT Heat recovery from deep/ultra-deep geothermal reservoirs and CO 2 storage in geologic formations are promising techniques for reducing CO 2 emissions. Both techniques involve injection of fluid into deep saline aquifers, oil/gas reservoirs, or stimulated fractured crystalline formations. A potential alternative to storing CO 2 in aquifers involves dissolution of CO 2 in the return (cold) water stream of geothermal doublets. The efficiency of injection and sweep, as well as the safety of operations highly depends on reservoir physical, thermal, and compositional properties, which may change following CO 2 and/or cooled water injection and potential reaction. However, although there is convincing evidence that thermal, flow, and chemical processes are strongly coupled, the nature of the coupling is not yet fully understood. In order to understand the spatial and temporal hydrothermal and chemical effects on targeted geologic media of CO 2 injection, a geometrically flexible approach for solving reactive non-isothermal densityviscosity-dependent flow and reactive transport in low-enthalpy geothermal systems is utilized. The method is applied to simulate the non-isothermal reactive flow transport in a doublet geothermal system. Several injection scenarios are analyzed. The overall heat recovery and CO 2 -storage capacity are calculated for different formations. Furthermore, the influence of both the induced viscosity and porosity changes on flow and heat transfer in such systems are investigated

Reflection of Scandinavian Ice Sheet Fluctuations in Norwegian Sea Sediments during the Past 150,000 Years

The record of glacier fluctuations in western Scandinavia, as reconstructed from continental data, has been correlated with records of ice-rafted detritus (IRD) from well-dated sediment cores from the Norwegian Sea covering the past 150,000 yr B.P. The input of IRD into the ocean is used as a proxy for ice sheet advances onto the shelf and, thus, for the calibration of a glaciation curve. The marine results generally support land-based reconstructions of glacier fluctuations and improve the time-control on glacial advances. The Saalian ice sheet decayed very rapidly approximately 125,000 yr B.P. In the Early Weichselian, a minor but significant IRD maximum indicates the presence of icebergs in isotope substage 5b (especially between 95,000 and 83,000 yr B.P.). Reduced amounts of calcareous nannofossils indicate that surface waters were influenced by meltwater discharges during isotope substages 5d and 5b. An extensive build-up of inland ice began again during isotope stage 4, but maximum glaciation was reached only in early stage 3 (58,000-53,000 yr B.P.). Marine sediments have minimum carbonate content, indicating strong dilution by lithogenic ice-rafted material. Generally, the IRD accumulation rate was considerably higher in stages 4-2 than in stage 5. A marked peak in IRD accumulation rates from 47,000 to 43,000 yr B.P. correlates well with a second Middle Weichselian ice sheet advance dated by the Laschamp/Olby paleomagnetic event. Minimum ice extent during the Ålesund interstade (38,500-32,500 yr B.P.) and several glacial oscillations during the Late Weichselian are also seen in the IRD record. Of several late Weichselian glacial oscillations on the shelf, at least four correspond to the North Atlantic Heinrich events. Ice sheet behavior was either coupled or linked by external forcing during these events, whereas internal ice sheet mechanisms may account for the noncoherent fluctuations

CRISTOPH – A cluster-randomised intervention study to optimise the treatment of patients with hypertension in General Practice

<p>Abstract</p> <p>Background</p> <p>Recent guidelines for the management of hypertension focus on treating patients according to their global cardiovascular risk (CVR), rather than strictly keeping blood pressure, or other risk factors, below set limit values. The objective of this study is to compare the effect of a simple versus a complex educational intervention implementing this new concept among General Practitioners (GPs).</p> <p>Methods/design</p> <p>A prospective longitudinal cluster-randomised intervention trial with 94 German GPs consecutively enroling 40 patients each with known hypertension. All GPs then received a written manual specifically developed to transfer the global concept of CVR into daily General Practice. After cluster-randomisation, half of the GPs additionally received a clinical outreach visit, with a trained peer discussing with them the concept of global CVR referring to example study patients from the respective GP. Main outcome measure is the improvement of calculated CVR six months after intervention in the subgroup of patients with high CVR (but no history of cardiovascular disease), defined as 10-year-mortality ≥ 5% employing the European SCORE formula. Secondary outcome measures include the intervention's effect on single risk factors, and on prescription rates of drugs targeting CVR. All outcome measures are separately studied in the three subgroups of patients with 1. high CVR (defined as above), 2. low CVR (SCORE < 5%), and 3. a history of cardiovascular disease. The influence of age, sex, social status, and the perceived quality of the respective doctor-patient-relation on the effects will be examined.</p> <p>Discussion</p> <p>To our knowledge, no other published intervention study has yet evaluated the impact of educating GPs with the goal to treat patients with hypertension according to their global cardiovascular risk.</p> <p>Trial registration</p> <p>ISRCTN44478543</p

The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation

Respiratory syncytial virus (RSV) is an important cause of acute respiratory disease in infants, immunocompromised subjects and the elderly. However, it is unclear why most primary RSV infections are associated with relatively mild symptoms, whereas some result in severe lower respiratory tract infections and bronchiolitis. Since RSV hospitalization has been associated with respiratory bacterial co-infections, we have tested if bacterial Toll-like receptor (TLR) agonists influence RSVA2- GFP infection in human primary cells or cell lines. The synthetic bacterial lipopeptide Pam3-Cys-Ser-Lys4 (Pam3CSK4), the prototype ligand for the heterodimeric TLR1/TLR2 complex, enhanced RSV infection in primary epithelial, myeloid and lymphoid cells. Surprisingly, enhancement was optimal when lipopeptides and virus were added simultaneously, whereas addition of Pam3CSK4 immediately after infection had no effect. We have identified two structurally related lipopeptides without TLR-signaling capacity that also modulate RSV infection, whereas Pam3CSK4-reminiscent TLR1/2 agonists did not, and conclude that modulation of infection is independent of TLR activation. A similar TLR-independent enhancement of infection could also be demonstrated for wild-type RSV strains, and for HIV-1, measles virus and human metapneumovirus. We show that the effect of Pam3CSK4 is primarily mediated by enhanced binding of RSV to its target cells. The Npalmitoylated cystein

Framework and baseline examination of the German National Cohort (NAKO)

The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19–74 years were recruited and examined in 18 study centres in Germany. The baseline assessment included a face-to-face interview, self-administered questionnaires and a wide range of biomedical examinations. Biomaterials were collected from all participants including serum, EDTA plasma, buffy coats, RNA and erythrocytes, urine, saliva, nasal swabs and stool. In 56,971 participants, an intensified examination programme was implemented. Whole-body 3T magnetic resonance imaging was performed in 30,861 participants on dedicated scanners. NAKO collects follow-up information on incident diseases through a combination of active follow-up using self-report via written questionnaires at 2–3 year intervals and passive follow-up via record linkages. All study participants are invited for re-examinations at the study centres in 4–5 year intervals. Thereby, longitudinal information on changes in risk factor profiles and in vascular, cardiac, metabolic, neurocognitive, pulmonary and sensory function is collected. NAKO is a major resource for population-based epidemiology to identify new and tailored strategies for early detection, prediction, prevention and treatment of major diseases for the next 30 years. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10654-022-00890-5

Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study

BACKGROUND: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains limited. OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. METHODS: Within the project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM 2.5), nitrogen dioxide (NO 2), black carbon (BC), and ozone (O 3), as well as 8 PM 2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. RESULTS: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM 2.5 (hazard ratio per 5 µg/m 3: 1.25; 95% confidence interval: 1.01-1.55), NO 2 (1.13; 0.95-1.34 per 10 µg/m 3), and BC (1.12; 0.94-1.34 per 0.5 × 10 -5m -1), and a negative association with O 3 (0.74; 0.58-0.94 per 10 µg/m 3). Associations of PM 2.5, NO 2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM 2.5 remained robust when adjusted for NO 2 (1.24; 0.95-1.62) or BC (1.28; 0.96-1.71), whereas associations with NO 2 or BC attenuated to null. O 3 associations remained negative, but no longer statistically significant in models with PM 2.5. We detected suggestive positive associations with the potassium component of PM 2.5. CONCLUSION: Long-term exposure to PM 2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality