Re atumela phetogo1: Africanisation in Embodied Actor-training Performance Platforms Incorporating Multimodal Learning Janine Lewis Karina Lemmer Abstract This article reports on the implementation of multimodal creative training employed for embodied per

This article reports on the implementation of multimodal creative training employed for embodied performance courses that include physical theatre and voice studies for actors. Awareness of embodiment is imperative for training actors, which in turn underpins the inherent nature of a visceral African performer and conceptual performance. However, attention to embodiment as a site of learning has been sporadic and paradoxically under-documented with-in the area of adult performing arts education. This article focuses on the potential of multimodality to challenge and re-imagine actor-training through implementation of performance platforms incorporating embodied-learning/ performance/ space(s) (embodied-LPS). The performance platform training was initially designed for the physical theatre training of Tshwane University of Technology (TUT) students in 2000, and this article reflects on how this multimodal training approach may be validated when reflecting on its application to the voice course since 2011. Using a reflective research design, association of practice was identified through lecturer’s observation and reflection on the teaching and assessment strategies employed to cluster sample groups of acting-training Bachelor of Technology (BTech) students. Strategies embrace multimodal, self-directed and cooperative learning, that integrate reflexive practice-based principles. The performance platforms are primarily practical applications of theoretical underpinnings that are explored, reflected upon and interpreted. Within the South African higher-education environment, the documentation and reflection in this article serve to validate that such multimodal (re)conceptual performance creativity facilitates transformation for the creative student through ownership learning and co-creation of new knowledge

Political economy model forecast: the left will win a comfortable victory in the Danish general election

With the Danish general election only a few days away, what can forecasting models tell us about the outcome? Drawing on a model that features economic growth, Richard Nadeau, Michael S. Lewis-Beck and Karina Kosiara-Pedersen predict a comfortable win for a left coalition led by the ruling Social Democrats

Increased IgG4-Positive Plasma Cells in Granulomatosis with Polyangiitis: A Diagnostic Pitfall of IgG4-Related Disease

Granulomatosis with polyangiitis (Wegener's) (GPA) may mimic IgG4-related disease (IgG4-RD) on histologic examination of some biopsies, especially those from head and neck sites. IgG4 immunostain is often performed in this context for differential diagnosis with IgG4-RD. However, the prevalence of IgG4+ cells in GPA has not been explored. We examined the IgG4+ cells in 26 cases confirmed as GPA by a thorough clinical and pathologic assessment. Twenty-six biopsies consisted of 14 sinonasal/oral cavity/nasopharynx, 7 orbit/periorbital, 3 lung/pleura, 1 iliac fossa/kidney, and 1 dura specimens. Eight of 26 (31%) biopsies revealed increased IgG4+ cells (>30/HPF and >40% in IgG4+/IgG+ ratio). The IgG4+ cells and IgG4+/IgG+ ratio ranged 37–137/hpf and 44–83%, respectively. Eight biopsies with increased IgG4+ cells were from sinonasal (n = 4) or orbital/periorbital (n = 4) sites. In conclusion, increased IgG4+ cells are not uncommonly seen in sinonasal or orbital/periorbital biopsies of GPA, which could pose as a diagnostic pitfall

Perceptions of Precision Agriculture Technologies in the U.S. Fresh Apple Industry

Advances in precision agriculture technologies provide opportunities to improve the efficiency of agricultural production systems, especially for high-value specialty crops such as fresh apples (Malus domestica). We distributed an online survey to apple growers in Washington, New York, and Michigan to elicit stakeholder perceptions of precision agriculture technologies. Findings from this study demonstrated that growers are willing to adopt precision agriculture technologies when they receive results from applied research projects and are engaged with active extension programs. The availability of customized services and purchasing and rental options may minimize the effects of the economies of size that create barriers to adopting increasing access to technologies. Finally, respondents deemed collaborative efforts between industry and academic institutions crucial for adapting the innovation to better address the needs of growers

Effects of Concurrent Depressive Symptoms and Perceived Stress on Cardiovascular Risk in Low‐ and High‐Income Participants: ...

Background: Psychosocial risk for cardiovascular disease (CVD) may be especially deleterious in persons with low socioeconomic status. Most work has focused on psychosocial factors individually, but emerging research suggests that the confluence of psychosocial risk may be particularly harmful. Using data from the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study, we examined associations among depressive symptoms and stress, alone and in combination, and incident CVD and all‐cause mortality as a function of socioeconomic status. Methods and Results At baseline, 22 658 participants without a history of CVD (58.8% female, 41.7% black, mean age 63.9±9.3 years) reported on depressive symptoms, stress, annual household income, and education. Participants were classified into 1 of 3 psychosocial risk groups at baseline: (1) neither depressive symptoms nor stress, (2) either depressive symptoms or stress, or (3) both depressive symptoms and stress. Cox proportional hazards models were used to predict physician‐adjudicated incident total CVD events (nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death) and all‐cause mortality over a median of 7.0 years (interquartile range 5.4–8.3 years) of follow‐up. In fully adjusted models, participants with both depressive symptoms and stress had the greatest elevation in risk of developing total CVD (hazard ratio 1.48, 95% CI 1.21–1.81) and all‐cause mortality (hazard ratio 1.33, 95% CI 1.13–1.56) but only for those with low income (< $35 000) and not high (≥$35 000) income. This pattern of results was not observed in models stratified by education. Conclusions Findings suggest that screening for a combination of elevated depressive symptoms and stress in low‐income persons may help identify those at increased risk of incident CVD and mortality

Low dietary intake of magnesium is associated with increased externalising behaviours in adolescents

Objective: Adequate Zn and Mg intakes may be beneficial for the prevention and treatment of mental health problems, such as depression, anxiety and attention-deficit hyperactivity disorder. We aimed to investigate the prospective association between dietary intakes of Zn and Mg and internalising and externalising behaviour problems in a population-based cohort of adolescents. Design: Prospective analysis (general linear mixed models) of dietary intakes of Zn and Mg assessed using a validated FFQ and mental health symptoms assessed using the Youth Self-Report (YSR), adjusting for sex, physical activity, family income, supplement status, dietary misreporting, BMI, family functioning and energy intake. Setting: Western Australian Pregnancy Cohort (Raine) Study. Subjects: Adolescents (n 684) at the 14- and 17-year follow-ups. Results: Higher dietary intake of Mg (per SD increase) was significantly associated with reduced externalising behaviours (β=−1·45; 95 % CI −2·40, −0·50; P=0·003). There was a trend towards reduced externalising behaviours with higher Zn intake (per SD increase; β=−0·73; 95 % CI −1·57, 0·10; P=0·085).Randomised controlled trials are necessary to determine any benefit of micronutrient supplementation in the prevention and treatment of mental health problems in adolescents.The study shows an association between higher dietary Mg intake and reduced externalising behaviour problems in adolescents. We observed a similar trend, although not statistically significant, for Zn intake. Randomised controlled trials are necessary to determine any benefit of micronutrient supplementation in the prevention and treatment of mental health problems in adolescents

The role of herbivorous insects and pathogens in the regeneration dynamics of Guazuma ulmifolia in Panama

A significant proportion of the mortality of rainforest trees occurs during early life stages (seeds and seedlings), but mortality agents are often elusive. Our study investigated the role of herbivorous insects and pathogens in the early regeneration dynamics of Guazuma ulmifolia (Malvaceae), an important tree species in agroforestry in Central America. We reared pre-dispersal insect seed predators from G. ulmifolia seeds in Panama. We also carried out an experiment, controlling insects and pathogens using insecticide and/or fungicide treatments, as well as seed density, and compared survivorship of G. ulmifolia seeds and seedlings among treatments and relative to untreated control plots. We observed (1) high pre-dispersal attack (92%) of the fruits of G. ulmifolia, mostly by anobiine and bruchine beetles; (2) negligible post-dispersal attack of isolated seeds by insects and pathogens; (3) slow growth and high mortality (> 95%) of seedlings after 14 weeks; (4) low insect damage on seedlings; and (5) a strong positive correlation between seedling mortality and rainfall. We conclude that for G. ulmifolia at our study site the pre-dispersal seed stage is by far the most sensitive stage to insects and that their influence on seedling mortality appears to be slight as compared to that of inclement weather. Thus, the regeneration of this important tree species may depend on effective primary dispersal of seeds by vertebrates (before most of the seed crop is lost to insects), conditioned by suitable conditions in which the seedlings can grow

Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery : Combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds

Objectives: To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods: Health Assessment Questionnaire (HAQ) disability scores were collected from two longitudinal early RA inception cohorts in routine care; Early Rheumatoid Arthritis Study and Early Rheumatoid Arthritis Network from 1986 to 2012. The incidence of major and intermediate orthopaedic surgical episodes over 25 years was collected from national data sets. Disease activity was categorised by mean disease activity score (DAS28) annually between years 1 and 5; remission (RDAS≤2.6), low (LDAS>2.6-3.2), low-moderate (LMDAS≥3.2-4.19), high-moderate (HMDAS 4.2-5.1) and high (HDAS>5.1). Results: Data from 2045 patients were analysed. Patients in RDAS showed no HAQ progression over 5 years, whereas there was a significant relationship between rising DAS28 category and HAQ at 1 year, and the rate of HAQ progression between years 1 and 5. During 27 986 person-years follow-up, 392 intermediate and 591 major surgeries were observed. Compared with the RDAS category, there was a significantly increased cumulative incidence of intermediate surgery in HDAS (OR 2.59 CI 1.49 to 4.52) and HMDAS (OR 1.8 CI 1.05 to 3.11) categories, and for major surgery in HDAS (OR 2.48 CI 1.5 to 4.11), HMDAS (OR 2.16 CI 1.32 to 3.52) and LMDAS (OR 2.07 CI 1.28 to 3.33) categories. There was no significant difference in HAQ progression or orthopaedic episodes between RDAS and LDAS categories. Conclusions: There is an association between disease activity and both poor function and long-term orthopaedic episodes. This illustrates the far from benign consequences of persistent moderate disease activity, and supports European League Against Rheumatism treat to target recommendations to secure low disease activity or remission in all patients.Peer reviewedFinal Published versio

A reference genome for the Chinese hamster based on a hybrid assembly strategy

Accurate and complete genome sequences are essential in biotechnology, especially to facilitate genome-based cell engineering efforts for the main production host of biotherapeutic proteins, Chinese hamster ovary (CHO) cells. While genome-enabled CHO cell engineering efforts promise to enhance drug production, the current genome assemblies for Cricetulus griseus, the Chinese hamster, are highly fragmented and replete with gap sequences and misassemblies, consistent with most short-read based assemblies. Here we have completely re-sequenced the Chinese hamster, C. griseus, using Single Molecule Real Time (SMRT) long-read technology and merged this assembly with Illumina-based assemblies. Please download the file below for full content