Expression of PRB, FKBP52 and HB-EGF Relating with Ultrasonic Evaluation of Endometrial Receptivity

Background: To explore the molecular basis of the different ultrasonic patterns of the human endometrium, and the molecular marker basis of local injury. Methodology/Principal Findings: The mRNA and protein expression of FKBP52, progesterone receptor A (PRA), progesterone receptor B (PRB), and HB-EGF were detected in different patterns of the endometrium by real-time RTPCR and immunohistochemistry. There were differences in the mRNA and protein expression of FKBP52, PRB, and HB-EGF in the triple line (Pattern A) and homogeneous (Pattern C) endometrium in the window of implantation. No difference was detected in PRA expression. After local injury, the mRNA expression of HB-EGF significantly increased. In contrast, there was no difference in the mRNA expression of FKBP52, PRB, or PRA. The protein expression of FKBP52, PRB, and HB-EGF increased after local injury. There was no difference in the PRA expression after local injury. Conclusions: PRB, FKBP52, and HB-EGF may be the molecular basis for the classification of the ultrasonic patterns. HB-EGF may be the molecular basis of local injury. Ultrasonic evaluation on the day of ovulation can be effective in predicting the outcome of implantation

The United States COVID-19 Forecast Hub dataset

Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, the United States Centers for Disease Control and Prevention (CDC) partnered with an academic research lab at the University of Massachusetts Amherst to create the US COVID-19 Forecast Hub. Launched in April 2020, the Forecast Hub is a dataset with point and probabilistic forecasts of incident cases, incident hospitalizations, incident deaths, and cumulative deaths due to COVID-19 at county, state, and national, levels in the United States. Included forecasts represent a variety of modeling approaches, data sources, and assumptions regarding the spread of COVID-19. The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data can be used to develop ensemble models, communicate forecasts to the public, create visualizations, compare models, and inform policies regarding COVID-19 mitigation. These open-source data are available via download from GitHub, through an online API, and through R packages

Comparision of the Efficacy of Vit B1 (Thiamine) and Ibuprofen in Treatment of Primary Dysmenorrhea in Young Girls, Yazd, 2003

Introduction: This study was performed in order to compare the efficacy of vitamin B1and Iboprofen in the treatment of primary dysmenorrhea. Methods: 180 women aged between 11-17 years with primary dysmenorrhea were divided to 2 groups: Group A: (n: 60) received 100mg vit B1 daily in leuteal phase for 3 months . Grope B :( n: 60) Received 400mg Ibuprofen 3 times/day for 5days (3 days before and 2 days after start of menses) for 3 months. Results: 80% of group A and 88.4% of group B were treated as compared to control (P=0001 ), but in group B, side effects were more and the regimen was less tolerated as compared to group A. Conclusion: Vit B (Thiamine) is well tolerated and effective drug without side effects in primary dysmenorrhea

Evaluation of Fluoxtinfor Treatm Ent of Menopausal Hot Flashes

Introduction: Hot flashes can be prominent problem in menopausal women. The treatment of hot flashes is hormonal thrapies but in some patients that are unable to use estrogen other treating hot flashes are required. Based on anecdotal information reqarding the efficacy of fluoxtin for treating hot flashes , the present trial was developed . Methods: This trial used a double Blinded randomized to study the effecacy of fluoxetin (20mg/day) and comparing with placebo in treating hot flash in 4 week treatment. Results: 310 women began protocol thrapy. in two group: A (flouxetine) and B-( placebo ) By the end of protocol hot flashes frequeney decreased 77.5 % with floxetin versus 13.7 % whith placebo( p=.0001)The flouxetin was well tolerated . Conclusion: Flouxetin resulted well improvent in hot flashes

Relationship among temporary separation, attachment styles, and adjustment in first-grade Iranian children

Siyamak Tahmasebi,1 Saman Mafakheri Bashmaq,2 Mansoureh Karimzadeh,3 Robab Teymouri,4 Mahdi Amini,5 Maryam Sadat M vaghefi,6 M Ali Mazaheri7 1Department of Preschool Education, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; 2Department of Psychology and Exceptional Children’s Education, Faculty of Psychology and Educational Sciences, Allameh Tabataba’i University, Tehran, Iran; 3Department of Preschool Education, Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; 4Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; 5Addiction Department, Center of Excellence in Psychiatry and Clinical Psychology, School of Behavioral Sciences and Mental Health, Institute of Tehran Psychiatry, Iran University of Medical Sciences, Tehran, Iran; 6Department of Speech Therapy, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; 7Department of Clinical Psychology, Shahid Beheshti University, Tehran, Iran Abstract: If mothers work outside the home, some degree of mother–child separation will be experienced and mother–child attachment will be affected. In this study, regarding the attachment styles, sociobehavioral problems in first-grade children with experience of preschool and in those taught by their mothers at-home are compared. A casual-comparative method was used to compare children in the two groups. A total of 320 first-grade children participated in the study. The study measures included a separation anxiety test, an adaptive behavior scale, and a children’s symptom inventory. Data were analyzed using multivariate statistics. Secure attachment in the group with experience of preschool was significantly higher than that in the at-home group. None of the variables, including parents’ education and father’s income, significantly affected attachment style. Neither father’s education, father’s income, or attachment significantly influenced adjustment. Father’s education significantly influenced children’s symptoms. Attachment style and hours of preschool attendance had no effect on Child Symptom Inventory scores. Associations among age at joining preschool, attachment style, and behavioral and adaptive problems in first-grade children were nonlinear and multivariate. By taking into account parents’ awareness, sensitivity, and responsiveness, relative welfare, appropriate quality of child-care centers, and having fewer hours of preschool attendance, the risk factors for early parent–child separation and institutional care can be reduced. Keywords: separation, attachment, adjustment, pathological symptoms, first-grade childre