Facile synthesis of bis(indolyl)methanes using iron(III) phosphate

A new, convenient and high yielding procedure for the preparation of bis(indolyl)methanes in glycerol by electrophilic substitution reaction of indole with aldehydes in the presence of catalytic amount of FePO4 (5.0 mol%) as a highly stable and reusable catalyst is described

Fe(III)-Catalyzed Cycloaddition Reaction of <i>In Situ</i> Formed Imines With Cyclic Enol Ethers

<div><p>Fe(ClO₄)₃ and silica gel adsorbed Fe(ClO₄)₃ are reported as catalysts for [4+2] cycloaddition reactions of imines (formed in situ from anilines and enol ethers) with cyclic enol ethers to afford the corresponding pyrano- and furano[3,2-c]quinolines in good to excellent yields. Also, the catalytic activity of Fe(ClO₄)₃ in different solvents was compared with the other iron catalysts such as FePO₄, Fe₂(SO₄)₃.XH₂O, (NH₄)Fe(SO₄)₂.12H₂O, Fe(acac)₃, Fe(DS)₃, Fe(OH)₃, FeCl₃.6H₂O, and Fe(NO₃)₃.9H₂O.</p></div

Computational investigation of the solvent and temperature effects on the tautomerization of 7-amino-1,3-dioxo-2,5-diphenyl-2,3-dihydro-1H, 5H-pyrazolo[1,2-a][1,2,4]triazole-6-carbonitrile

617-622This research examines the effects of solvent polarity and temperature on the tautomerization of 7-amino-1,3-dioxo-2, 5-diphenyl-2,3-dihydro-1H,5H-pyrazolo[1,2-a][1,2,4]triazole-6-carbonitrile at CAM-B3LYP/6-311G (d,p) level of theory. The selected solvents are n-hexane, diethyl ether, pyridine, ethanol, methanol, and water. The solvent effects have been examined by the self-consistent reaction field theory (SCRF) based on conductor-like polarizable continuum model (CPCM). The solvent effects have been explored on the energy barrier, frontier orbitals energies, and HOMO-LUMO gap. Dependencies of thermodynamic parameters (G andH) on the dielectric constants of solvents have also been tested. Specifically, the temperature dependencies of the thermodynamics parameters have been studied within 100-1000 K range. The rate constant of the tautomerism reaction is computed from 300 to 1200 K, in the gas phase

Computational investigation of the solvent and temperature effects on the tautomerization of 7-amino-1,3-dioxo-2,5-diphenyl-2,3-dihydro-1H, 5H-pyrazolo[1,2-a][1,2,4]triazole-6-carbonitrile

This research examines the effects of solvent polarity and temperature on the tautomerization of 7-amino-1,3-dioxo-2, 5-diphenyl-2,3-dihydro-1H,5H-pyrazolo[1,2-a][1,2,4]triazole-6-carbonitrile at CAM-B3LYP/6-311G (d,p) level of theory. The selected solvents are n-hexane, diethyl ether, pyridine, ethanol, methanol, and water. The solvent effects have been examined by the self-consistent reaction field theory (SCRF) based on conductor-like polarizable continuum model (CPCM). The solvent effects have been explored on the energy barrier, frontier orbitals energies, and HOMO-LUMO gap. Dependencies of thermodynamic parameters (DG andDH) on the dielectric constants of solvents have also been tested. Specifically, the temperature dependencies of the thermodynamics parameters have been studied within 100-1000 K range. The rate constant of the tautomerism reaction is computed from 300 to 1200 K, in the gas phase

Assessment of adaptive response of gamma radiation in the operating room personnel exposed to anesthetic gases by measuring the relative gene expression changes KU80, LIGASE1 and P53

Background: Some operating room personnel are occupationally exposed to genotoxic agents such as anesthetic gases and ionizing radiation. Adaptive response, as a defense mechanism, will occur when cells become exposed to a low dose of factors harming DNA (priming dose), which in the subsequent exposure to higher dose of those factors (challenging dose), show more resistance and sensibility. Objective: The aim of this study was to investigate adaptive response or synergy of ionizing radiation in the operating room personnel exposed to anesthetic gases by evaluation of the relative gene expression changes of effective genes for DNA repair such as Ku80, Ligase1 and P53. Material and Methods: In this case-control study, 20 operating room personnel and 20 nurses (who were not present in the operating room) as controls were studied. Venous blood samples were drawn from participants. In order to evaluate the adaptive response, a challenging dose of 2Gy gamma radiation was applied to blood samples. Moreover, RNA extraction and cDNA synthesis were performed. Gene expression level was studied by RT-qPCR and compared with the control group. Results: Ligase1 and P53 expression in the operating room personnel was signifi-cantly higher than that of the control group before irradiation (P�0.001). Statistically, there was no significant difference in the Ku80 and P53 expression in the operating room personnel before and after irradiation. Conclusion: Given the findings of this study, exposure to challenging dose of gamma radiation can induce adaptive response in expression of Ku80 and P53 genes in operating room personnel. © 2020, Shiraz University of Medical Sciences. All rights reserved

The Effects of Processing Instruction and Output-Based Activities on Grammar Learning: The Mediating Role of Working Memory

Processing instruction (PI) is an input-based approach to grammar education based on input processing theory, and output is another element needed for second-language acquisition to be successful. This study sought to examine the impact of PI and output-based activities with the mediating role of working memory (WM) capacity on learning English future tense. To this end, 99 subjects with preintermediate command of English based on an Oxford Placement Test were recruited for the study, and they were divided into three groups: PI, output, and control, with 33 learners in each group. Using a reading-span test, it was revealed that 14 subjects in the PI group, 15 participants in the output group, and 13 learners in the comparison group had low WM, while the rest individuals had high WM capacity. Then, a two-way between-group analysis of variance and a Bonferroni adjustment post hoc test were performed. The results of the analyses showed that both PI and output groups outperformed the control group. Additionally, there was no difference in grammar gain between PI and output groups. Besides, learners with high WM outperformed low WM individuals. The pedagogical implication of this research is that PI and output-based activities can assist teachers in implementing effective strategies to raise L2 learners’ knowledge and consciousness