Correctional Change Through Neuroscience

Currently, the U.S. criminal justice system is under intense scrutiny. High- profile cases question the appropriateness of specific types of evidence, decision making in sentencing, and the treatment of convicted offenders. Clearly, these issues are not new. And, as has been historically the case, the justice system looks toward science for assistance in addressing and redressing problems with the delivery of justice

Foreword

This Foreword provides an overview of Criminal Behavior and the Brain: When Law and Neuroscience Collide, a symposium hosted by the Fordham Law Review and cosponsored by the Fordham Law School Neuroscience and Law Center. While the field of neuroscience is vast—generally constituting “the branch of the life sciences that studies the brain and nervous system”— this symposium focused on the cutting-edge ties between neuroscience evidence and the different facets of criminal law. Such an intersection invited commentary from an expert group on a wide span of topics, ranging from the historical underpinnings between law and neuroscience to the treatment of young adults to the different roles of neuroscience in the context of sentencing, expert testimony, defenses, prediction, punishment, and rehabilitation, as well as the civil and criminal divide. These diverse subjects have an overarching theme in common: each pertains in some way to the criminal justice system’s effort to punish or rehabilitate more fairly and effectively

Simultaneous detection rates of binary neutron star systems in advanced Virgo/LIGO and GRB detectors

The coalescence of two compact objects is a key target for the new gravitational wave observatories such as Advanced-Virgo (AdV), Advanced-LIGO (aLIGO) and KAGRA. This phenomenon can lead to the simultaneous detection of electromagnetic waves in the form of short GRBs (sGRBs) and gravitational wave transients. This will potentially allow for the first time access to the fireball and the central engine properties. We present an estimation of the detection rate of such events, seen both by a Swift-like satellite and AdV/ALIGO. This rate is derived only from the observations of sGRBs. We show that this rate, if not very high, predicts a few triggers during the whole life time of Advanced LIGO-Virgo. We discuss how to increase it using some dedicated observational strategies. We apply our results to other missions such as the SVOM French-Chinese satellite project or LOFT.Comment: 7 pages, 1 figure, 7th Huntsville Gamma-Ray Burst Symposium, GRB 2013: paper 18 in eConf Proceedings C130414

Simultaneous event detection rates by electromagnetic and gravitational wave detectors in the Advanced Era of LIGO and Virgo

We present several estimates of the rate of simultaneous detection of the merging of a binary system of neutron stars in the electromagnetic and the gravitational wave domains, assuming that they produce short GRBs. We have based our estimations on a carefully selected sample of short gamma-ray bursts, corrected from redshift effects. The results presented in this paper are based on actual observation only. In the electromagnetic spectrum, we considered observations by current (Swift and Fermi}) and future (LOFT and SVOM) missions. In the gravitational wave domain, we consider detections by the Advanced Virgo instrument alone and the network of both Advanced LIGO and Advanced Virgo. We discuss on the possible biases present in our sample, and how to fix them. For present missions, assuming a detection in the following years, we find that we should observe simultaneously between 0.11 and 4.2 gravitational wave events per year with Swift} and Fermi} respectively. For future projects (LOFT and SVOM) we can expect less than one common detection per year. We check the consistency of our results with several previously published rate of detection of gravitational waves.Comment: 7 pages, accepted for publication in MNRAS, with note added in proof correcting the rates for Fermi/SVOM experiment. Added tables 5 and 6 that are corrected and replace tables 2 and

A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method

Determine the inhibition mechanism through which cyclosporine inhibits the uptake and metabolism of atorvastatin in fresh rat hepatocytes using mechanistic models applied to data generated using a high throughput oil spin method. Atorvastatin was incubated in fresh rat hepatocytes (0.05–150 nmol/ml) with or without 20 min pre-incubation with 10 nmol/ml cyclosporine and sampled over 0.25–60 min using a high throughput oil spin method. Micro-rate constant and macro-rate constant mechanistic models were ranked based on goodness of fit values. The best fitting model to the data was a micro-rate constant mechanistic model including non-competitive inhibition of uptake and competitive inhibition of metabolism by cyclosporine (Model 2). The association rate constant for atorvastatin was 150-fold greater than the dissociation rate constant and 10-fold greater than the translocation into the cell. The association and dissociation rate constants for cyclosporine were 7-fold smaller and 10-fold greater, respectively, than atorvastatin. The simulated atorvastatin-transporter-cyclosporine complex derived using the micro-rate constant parameter estimates increased in line with the incubation concentration of atorvastatin. The increased amount of data generated with the high throughput oil spin method, combined with a micro-rate constant mechanistic model helps to explain the inhibition of uptake by cyclosporine following pre-incubation

The macroeconomic foundations of inclusive middle-class growth :

Poverty reduction, Hunger, Inclusive growth, Middle-class, Pro-poor growth, Global Markets, Fiscal discipline, Fair tax,

Reflections on the Macro Foundations of the Middle Class in the Developing World

In this working paper I define inclusive growth as growth conducive to increasing the size and economic command of the middle class. I suggest a definition of the middle class based on absolute and relative measures of country-based income distributions, and present evidence of change in the size of the “middle class” for selected developing countries. I then review how macroeconomic policies shape the environment and incentives for inclusive growth, focusing on three areas: fiscal discipline, the more rule-based the better; a fair tax and redistribution system; and a business friendly exchange rate. The adoption of macro policies that favor the middle class lays the foundation for more economically and politically sustainable development. While on the whole sound macro policy that is good for the middle class is also likely to be pro-poor, tradeoffs may exist with respect to tax, expenditure and transfer programs and responses to economic shocks. Governments should consider the weighted welfare outcomes of alternative approaches to macro policy, rather than un-weighted growth or overly weighted poverty outcomes.macroeconomics, sustainable development, middle class

A Bayesian dose-finding design for drug combination clinical trials based on the logistic model

International audienceIn early phase dose-finding cancer studies, the objective is to determine the maximum tolerated dose, defined as the highest dose with an acceptable dose-limiting toxicity rate. Finding this dose for drug-combination trials is complicated because of drug–drug interactions, and many trial designs have been proposed to address this issue. These designs rely on complicated statistical models that typically are not familiar to clinicians, and are rarely used in practice. The aim of this paper is to propose a Bayesian dose-finding design for drug combination trials based on standard logistic regression. Under the proposed design, we continuously update the posterior estimates of the model parameters to make the decisions of dose assignment and early stopping. Simulation studies show that the proposed design is competitive and outperforms some existing designs. We also extend our design to handle delayed toxicities. Copyright © 2014 John Wiley & Sons, Ltd