Evaluación del consumo de carnes procesadas en niños (6-10 años): Muestra de una escuela primaria en Estambul, Turquía

ABSTRACT Introduction: Processed meat has undesirable effects on overall diet quality especially in children and adolescents because the high consumption could increase the prevalence of obesity, cardiovascular disease, diabetes, and cancer. This study was carried out to evaluate the processed meat consumption of children (between 6-10 ages) and to observe their parents' attitudes on processed meat consumption and purchasing. Material and methods: A cross-sectional study was conducted with 297 children in the 1st to 4th classes of an elementary school in İstanbul and their parents. Children processed meat consumption and parents’ opinion about processed meat, attitudes during shopping were analyzed. Chi-square, Spearman correlation, Kruskal Wallis (Tamhane) analyses were applied with Statistical Package for the Social Sciences (SPSS). Results were assessed in 95% confidence interval (CI) and p < 0.05 significance level. Results: The first parents’ attitude during shopping was analyzed expiration date. The price tag on the package was the last attitude. Body Mass Index (BMI) of children and processed meat consumption wasn’t related statistically (p>0.05), but increasing age was statistically related to higher processed meat consumption (p<0.05). Parents of children who believe in the adverse effect of processed meat consumed less (p<0.05). Conclusions: Most of the parents decreased processed meat consumption because of its adverse health effect. Parents prepared lunch boxes and preferred homemade food for their children. While the educational level of parents decreased, the amount of processed meat consumption of children increased.Introducción: La carne procesada tiene efectos indeseables en la calidad de la dieta especialmente en niños y adolescentes, ya que el alto consumo podría aumentar la prevalencia de obesidad, enfermedades cardiovasculares, diabetes y cáncer. El objetivo del estudio fue registrar el consumo de carne procesada en niños (entre 6 y 10 años de edad) y observar las actitudes de sus padres sobre el consumo y compra de carne procesada. Material y métodos: Estudio transversal con la participación de 297 escolares de 1º a 4º año de una escuela primaria de Estambul y sus padres. Se registró el consumo de carne procesado por los niños, así como las opiniones y actitudes durante la compra de carne procesada de los padres. Se realizó análisis de Chi-cuadrado, correlación de Spearman, Kruskal Wallis (Tamhane) en el programa estadístico SPSS. Los resultados se evaluaron en el intervalo de confianza (IC) del 95% y en el nivel de significancia de p < 0,05. Resultados: Durante las compras, lo primero que analizaban los padres era la fecha de caducidad, mientras que el precio era analizado al final. No se observó relación estadísticamente significativa entre el Índice de Masa Corporal (IMC) de los niños y el consumo de carne procesada (p>0.05). Sin embargo, la edad y el consumo de carne procesada mostraron relación positiva estadísticamente significativa (p<0.05). Los hijos de padres que renocían el efecto adverso del consumo de carne procesada presentaron mejor consumo de carne procesada (p < 0.05). Conclusiones: La mayoría de los padres disminuyeron el consumo de carne procesada debido a loa efectos adversos sobre la salud, prefiriendo la preparación de comida en casera. Los padres con mayor nivel educativo disminuyeron el consumo de carne procesada de sus hijos

Prospective evaluation of free radicals and antioxidant activity following 6-month risedronate treatment in patients with postmenopausal osteoporosis

In addition to the well-described implications of estrogen deficiency in postmenopausal osteoporosis (PMO), free radicals are also effective on bone metabolism. The antioxidant vitamins C and E play an important role in the production of collagen, mesenchymal cell differentiation into osteoblasts, and bone mineralization. Therefore, the incidence of osteoporosis and the risk of fractures were decreased with vitamin C and E. It was proposed that free oxygen radicals are responsible for biological aging, atherosclerosis, carcinogenesis, and osteoclastic activity via their negative effects on the cell and DNA. In this study, we aimed to investigate and compare the levels of free radicals and serum antioxidant activity in patients with PMO and healthy subjects before and after six-month treatment with risedronate, which is an inhibitor of bone resorption. Twenty-three postmenopausal patients aged between 52–83 (mean [± standard deviation] 67.6 ± 8.17) with T scores below -2.5 in femur neck or L1-L4, and 23 postmenopausal healthy subjects were enrolled into the study. Patients who had received any medications within the last 6 months that could alter bone metabolism were excluded. Serum malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels were analyzed in both groups. The patients with PMO were commenced on 5 mg of risedronate, 1,200 mg of calcium, and 800 IU of vitamin D daily. The patients were reevaluated at the end of the sixth month. MDA and SOD levels were similar in patients with PMO when compared to the healthy group before the treatment, while the GPx levels were lower in patients with PMO (P = 0.014). GPx (P = 0.028) and MDA (P = 0.04) levels were increased in patients with PMO after the treatment. In contrast, SOD levels were decreased when compared to the initial levels (P = 0.006). There may be an insufficiency in different steps of the enzymatic antioxidant systems in patients with PMO without treatment. We observed an increment in lipid peroxidation levels and GPx levels with risedronate. We think that the decrement in SOD levels may be related with the utilized antioxidants due to the increased free radicals and the compensatory increment in the other steps of the antioxidant system

Retrospective analysis of Turkish AML registry database, on behalf of AML working group of Turkish society of hematology

Abstract Introduction: To investigate the demographics and treatment details of the acute myeloid leukemia (AML) patients who were diagnosed and followed up in Turkey. Methods: Patients who were recorded on the database of Turkish AML Registry project were included in this study retro- spectively if they were diagnosed before 1st of Jan 2022. Demographics, patient, and disease related parameters both at the time of diagnosis and at the follow up and treatment outcomes were presented

Clinical outcomes and treatment patterns of primary central nervous system lymphoma: Multicenter retrospective analysis

Objectives: Primary central nervous system lymphoma (PCNSL) is a rare malignant disease with poor prognosis. Its low incidence leads to challenges in decision-making for treatment. As a matter of fact, there is still no consensus on the appropriate treatment modalities. In this context, the objective of this study is to investigate and comparatively assess the efficacies of several treatment modalities in the treatment of PCNSL. Methods: Thirty-four patients diagnosed with PCNSL at 5 different hematology centers between 2007 and 2021 were included in the study. Patients’ data from all five centers were collected retrospectively. Since ibrutinib is not approved for this indication in Turkey, consent for off-label use of ibrutinib is obtained from each patient. Ethics committee ap-proval was obtained on June 9, 2021 with decision number 2021/18-05. Results: The median age of the patients was 59 (min.: 22, max.: 78) years. The male-to-female ratio was 1.26/1. Nineteen (55.9%) patients had Eastern Cooperative Oncology Group (ECOG) performance score of ≥2. Fifteen (44.1%) patients had normal lactate dehydrogenase (LDH) levels and only 14.7% of the patients had B symptoms at the time of diagnosis. Magnetic resonance imaging (MRI) revealed a single mass lesion in 14 (41.2%) patients. As an induction therapy, meth-otrexate-based regimen was administered in 29 (85.3%) patients. Only 14 of the 34 patients received 4 or more cycles of high-dose methotrexate (MTX). About 32.4% of the patients received radiation therapy (RT) during follow-up as a part of induction therapy. Five patients received only RT due to poor performance status. Ibrutinib was administered in 5 patients for refractory disease. It was determined that four or more cycles of MTX treatment increased progression-free survival (PFS) (p=0.031) and overall survival (OS) (p=0.012). Moreover, RT improved PFS (p=0.023). Considering that the complete response achieved by induction therapy influences long-term survival, achievement of the best response to the treatment regimens administered in combination with new agents may prolong survival (PFS: p=0.01, OS: p=0.023). Conclusion: The findings of this study indicate that the initial response to treatment is crucial. Additionally, it was found that high-dose MTX treatment should be administered for 4 cycles or more in order to achieve the best results. Furthermore, it was determined that ibrutinib monotherapy was well-tolerated in our patients with relapsed/refractory disease, with excellent clinical benefits. In conclusion, a combination therapy consisting of high-dose MTX, ibrutinib, and rituximab appears to be a promising initial treatment approach in appropriate patients

Assessment of processed meat consumption in children (6 -10 years old): Sample of an elementary school in Istanbul, Turkey

Introducción: La carne procesada tiene efectos indeseables en la calidad de la dieta especialmente en niños y adolescentes, ya que el alto consumo podría aumentar la prevalencia de obesidad, enfermedades cardiovasculares, diabetes y cáncer. El objetivo del estudio fue registrar el consumo de carne procesada en niños (entre 6 y 10 años de edad) y observar las actitudes de sus padres sobre el consumo y compra de carne procesada. Material y métodos: Estudio transversal con la participación de 297 escolares de 1º a 4º año de una escuela primaria de Estambul y sus padres. Se registró el consumo de carne procesado por los niños, así como las opiniones y actitudes durante la compra de carne procesada de los padres. Se realizó análisis de Chi-cuadrado, correlación de Spearman, Kruskal Wallis (Tamhane) en el programa estadístico SPSS. Los resultados se evaluaron en el intervalo de confianza (IC) del 95% y en el nivel de significancia de p < 0,05. Resultados: Durante las compras, lo primero que analizaban los padres era la fecha de caducidad, mientras que el precio era analizado al final. No se observó relación estadísticamente significativa entre el Índice de Masa Corporal (IMC) de los niños y el consumo de carne procesada (p>0.05). Sin embargo, la edad y el consumo de carne procesada mostraron relación positiva estadísticamente significativa (p<0.05). Los hijos de padres que reconocían el efecto adverso del consumo de carne procesada presentaron mejor consumo de carne procesada (p < 0.05). Conclusiones: La mayoría de los padres disminuyeron el consumo de carne procesada debido a loa efectos adversos sobre la salud, prefiriendo la preparación de comida casera. Los padres con mayor nivel educativo disminuyeron el consumo de carne procesada de sus hijos