Paediatric Behçet’s Disease: Data From A Single Center Experience In Turkey

ABSTRACT Objectives: Behçet’s disease (BD) is a multisystemic inflammatory disease with unknown etiology. It is characterized by recurrent oral and genital ulcerations, uveitis, and skin lesions, various musculoskeletal, gastrointestinal, central nervous system, and vascular manifestations. The aim of this study was to analyse the demographic characteristics and clinical features, treatment in Turkish paediatric BD from a single center experience.   Methods: The records 36 patients with BD who were diagnosed according to the International Study Group criteria between January 2017 and January 2019 in the department of paediatric rheumatology, were retrospectively reviewed. Data on demographic, clinical features and therapy were collected. Results: A total of 36 (19 male) patients were included in this study. Mean age at disease onset was 9.36 ± 4.45 years and mean age at diagnosis 13.99 ± 2.83 years. The frequencies of signs/symptoms were: recurrent oral aphtosis 100%, genital ulcers 80.6%, musculoskeletal 30.6%, ocular 16.7%, neurological 11.1% and vascular involvement 11.1%, gastrointestinal 2.8%. Colchicine and corticosteroids were the main treatments. Conclusions: In this single-center retrospective study, we analyzed the data of paediatric BD and their treatment from a single center in Turkey. The presented small series and the literature review suggest that paediatric BD is a heterogeneous disease with varied clinical manifestations

Crizotinib efficacy and safety in patients with advanced NSCLC harboring MET alterations: A real-life data of Turkish Oncology Group

Crizotinib is a multikinase inhibitor, effective in non-small cell lung cancer (NSCLC) harboring mesenchymal-epidermal transition (MET) alterations. Although small prospective studies showed efficacy and safety of crizotinib in NSCLC with MET alterations, there is limited real-life data. Aim of this study is to investigate real-life efficacy and safety of crizotinib in patients with advanced NSCLC harboring MET alterations. This was a retrospective, multicenter (17 centers) study of Turkish Oncology Group. Patients' demographic, histological data, treatment, response rates, survival outcomes, and toxicity data were collected. Outcomes were presented for the study population and compared between MET alteration types. Total of 62 patients were included with a median age of 58.5 (range, 26-78). Major histological type was adenocarcinoma, and 3 patients (4.8%) had sarcomatoid component. The most common MET analyzing method was next generation sequencing (90.3%). MET amplification and mutation frequencies were 53.2% (n = 33) and 46.8% (n = 29), respectively. Overall response rate and disease control rate were 56.5% and 74.2% in whole study population, respectively. Median progression free survival (PFS) was 7.2 months (95% confidence interval [CI]: 3.8-10.5), and median overall survival (OS) was 18.7 months (95% CI: 13.7-23.7), regardless of treatment line. Median PFS was 6.1 months (95% CI: 5.6-6.4) for patients with MET amplification, whereas 14.3 months (95% CI: 6.7-21.7) for patients with MET mutation (P = .217). Median PFS was significantly longer in patients who have never smoked (P = .040), have good performance score (P < .001), and responded to the treatment (P < .001). OS was significantly longer in patients with MET mutation (25.6 months, 95% CI: 15.9-35.3) compared to the patients with MET amplification (11.0 months; 95% CI: 5.2-16.8) (P = .049). In never-smokers, median OS was longer than smoker patients (25.6 months [95% CI: 11.8-39.3] vs 16.5 months [95% CI: 9.3-23.6]; P = .049). The most common adverse effects were fatigue (50%), peripheral edema (21%), nausea (29%) and diarrhea (19.4%). Grade 3 or 4 adverse effects were observed in 6.5% of the patients. This real-life data confirms efficacy and safety of crizotinib in the treatment of advanced NSCLC harboring MET alteration

Examen de los factores que afectan los niveles de agresión de los fanáticos del fútbol: muestras en Turquía

[Abstract] Fan aggression is a societal problem that affects many sports clubs worldwide. It should be handled in all dimensions to prevent individual and social aggression in sports environments. The study aims to examine the factors affecting the aggression levels of football fans. The study sample consisted of 909 people, 474 males, and 435 females. In addition to the personal information form, the "Buss-Perry Aggression Questionnaire" and "Football Fanaticism Scale" were used as data collection tools. Pearson Product Moment Correlation Analysis was used to determine the relationships between variables, and Multiple Linear Regression Analysis was used to examine the predictive power of independent variables on aggression. In addition, the Independent Samples T-Test was conducted to compare aggression in terms of gender. The results show that aggression predicts fanaticism positively, team identity, age, and education level negatively. In addition, it was observed that males exhibited high levels of physical and verbal aggression, while the females had high team identities. As a result, it can be said that fanaticism, team identity, age, education level, and gender are the main predictors of aggression (40%).[Resumen] La agresión de los fanáticos es un problema social que afecta a muchos clubes deportivos en todo el mundo. Debe ser manejado en todas sus dimensiones para prevenir agresiones individuales y sociales en ambientes deportivos. El estudio tiene como objetivo examinar los factores que afectan los niveles de agresión de los aficionados al fútbol. La muestra del estudio estuvo compuesta por 909 personas, 474 hombres y 435 mujeres. Además del formulario de información personal, se utilizaron como herramientas de recolección de datos el "Cuestionario de agresión de Buss-Perry" y la "Escala de fanatismo por el fútbol". Se utilizó el análisis de correlación producto-momento de Pearson para determinar las relaciones entre las variables, y se utilizó el análisis de regresión lineal múltiple para examinar el poder predictivo de las variables independientes sobre la agresión. Además, se realizó la prueba T de muestras independientes para comparar la agresión en términos de género. Los resultados muestran que la agresión predice positivamente el fanatismo, negativamente la identidad del equipo, la edad y el nivel educativo. Además, se observó que los hombres exhibían altos niveles de agresión física y verbal, mientras que las mujeres tenían altas identidades de equipo. Como resultado, se puede decir que el fanatismo, la identidad del equipo, la edad, el nivel educativo y el género son los principales predictores de agresión (40%)

Conservation of cultural landscapes in historical cities: the case study of Edirne Macedonia tower and archaeological site

Historical cities struggle to accommodate to rapid alteration and development under the influence of globalization and urbanization on the one hand, and on the other hand strive to conserve historical and cultural values. Cultural landscapes are the most important cultural heritage reflecting the layered cultural heritage of a historical city and helping to understand the traces of a society's life, which needs to be reevaluated and maintained in order to meet today's requirements. Today, cultural landscapes are the areas that are mainly affected by rapid social and economic changes in historic cities and are under threat. From the past to the present day, the foundation such as Council of Europe, UNESCO, USA The National Park Service and Parks Canada aimed to ensure the preservation and continuity of cultural landscapes by publishing various documents. In this context, in the research, the cultural landscape of the Macedonian Tower and its surrounding Archaeological Site, located in Edirne, which has a layered urban pattern with different cultural and architectural accumulations of different civilizations, has been investigated in the framework of the conservation policies and strategies of cultural landscapes. In the direction of literature data and visual examination, the current situation of the research area has been analysed and suggestions have been offered to ensure the cultural continuity by considering the balance of protection-use. © Peter Lang AG 2020

Analysis of bioclimatic comfort of tekirdag (Turkey) province with geographical information systems

Bioclimatic comfort is climate conditions in which human feel himself healthier and dynamic. The methodology for bioclimatic comfort mapping is presented to the need of urban decision makers and planners. The comfort maps use to an urban environment at the scale of neighbourhood and aim to assist in predicting and assessing bioclimatic conditions. In this study, the temperature from 11 meteorological stations in and around the province of Tekirdag, humidity and wind data are used. Data were evaluated with Kriging technical and climatic maps were generated. Then overlay analysis has been put forward in terms of comfort and bioclimatic areas.Namik Kemal University Scientific Research ProjectNamik Kemal University [NKUBAP.08.GA.16.015]This article is supported by Namik Kemal University Scientific Research Project (NKUBAP.08.GA.16.015) 'Analysis of Bioclimatic Comfort of Tekirdag Province with Geographical Information Systems'

Preparation of noise maps of Balkan Campus of Trakya University (Edirne-Turkey) by using geographic information systems

Noise in cities is a global problem which has been studied extensively around the world. Today, noise pollution is considered a public health problem for cities and it has many harmful effects on the citizens. There are varieties of noise generation sources of which the traffic noise could be a major source. The point which is perhaps less noticed is that sound level is not the only parameter to indicate the extent and intensity of noise pollution. Noise modeling is also used to determine the impact assessment from large geographical areas to a street. The noise maps generated at ground level over such areas are important tools for assessing the impact of traffic, human, industrial, domestic and transportation sources based noise on human populations at the surrounding. To produce an accurate noise maps, usage of validated and representative noise model is an essential step for the purposes of noise analysis. These maps are a cartographic representation of the noise level distribution in a determined area and period of time. The study area, Edirne is near-by to Greece and Bulgaria. Therefore, there is more car entrance to Edirne from these countries and especially the city main roadway/transport route is used. This is one of the factors that increases the noise pollution in the city. The aim of the study was to explore sources of noise pollution and to make environmental noise measurements in Balkan Campus of Trakya University of Edirne which is located near the main roadway of the city. Noise levels will be measured on 12 different points (at the intersection of the main axis of the campus and the roadway) between 8.00-18.00 h and the results will be analysed statistically. According to this analysis noise maps were generated. Noise maps were evaluated and planting design intended for noise pollution reduction were suggested for the campus area. @ 2018 Scibulcom Ltd. All Rights Reserved

Preparation of Noise Maps of Balkan Campus of Trakya University (Edirne-Turkey) By Using Geographic Information Systems

Noise in cities is a global problem which has been studied extensively around the world. Today, noise pollution is considered a public health problem for cities and it has many harmful effects on the citizens. There are varieties of noise generation sources of which the traffic noise could be a major source. The point which is perhaps less noticed is that sound level is not the only parameter to indicate the extent and intensity of noise pollution. Noise modeling is also used to determine the impact assessment from large geographical areas to a street. The noise maps generated at ground level over such areas are important tools for assessing the impact of traffic, human, industrial, domestic and transportation sources based noise on human populations at the surrounding. To produce an accurate noise maps, usage of validated and representative noise model is an essential step for the purposes of noise analysis. These maps are a cartographic representation of the noise level distribution in a determined area and period of time. The study area, Edirne is near-by to Greece and Bulgaria. Therefore, there is more car entrance to Edirne from these countries and especially the city main roadway/transport route is used. This is one of the factors that increases the noise pollution in the city. The aim of the study was to explore sources of noise pollution and to make environmental noise measurements in Balkan Campus of Trakya University of Edirne which is located near the main roadway of the city. Noise levels will be measured on 12 different points (at the intersection of the main axis of the campus and the roadway) between 8.00-18.00 h and the results will be analysed statistically. According to this analysis noise maps were generated. Noise maps were evaluated and planting design intended for noise pollution reduction were suggested for the campus area

Edirne Saraclar Street Pedestrian Comfort Analysis

Pedestrian areas, one of the essential elements of urban spaces, constitute a platform that allows citizens and visitors to connect and socialise with different people. These areas, where the pedestrians carry out compulsory, optional and social activities, are physical, social and economic contributions to urban life and are places that animate urban life. Especially in the pedestrianised streets which are planned to protect the central functions of the city, to revive the economy, to improve the image of the city and to ensure that the walking functions of the pedestrians at the optimum level and to perform all other activities comfortably depend on the natural characteristics, the built environment, the design elements and function areas of these streets. In this context, it is aimed to present the pedestrian comfort analysis of the 1st stage pedestrian area of Saraclar street which is the first and most important pedestrianisation example of Edirne city. The pedestrian counts were measured at 5 points of Saraclar street at weekends and weekday morning (08.00-09.00), noon (12.00-13.00) and evening (17.00-18.00), and spatial distribution of pedestrians was calculated by Inverse distance weight (IDW) geostatistical interpolation method. In addition to these measurements which provide the analysis of walking comfort of the pedestrians in the study area, flow rate, density and speed of pedestrians were calculated to provide revealing of this analysis. This analysis has helped to determine pedestrian comfort level of the street according to Level of service (LOS) by the Highway capacity manual (HCM). In this context, the structural and plant materials and physical features of the street were evaluated and pedestrian comfort analysis was presented. As a result of the study, proposals were presented considering the characteristics of the pedestrianised areas in order to increase pedestrian comfort of Saraslar street

Predicting Diel, Diurnal and Nocturnal Dynamics of Dissolved Oxygen and Chlorophyll-a Using Regression Models and Neural Networks

Human-induced and natural interruptions with continuous streams of observational data necessitate the development of gap-filling and prediction strategies towards better understanding, monitoring and management of aquatic systems. This study quantified the efficacy of multiple non-linear regression (MNLR) versus artificial neural network (ANN) models as well as the temporal partitioning of diurnal versus nocturnal data for the predictions of chlorophyll-a (chl-a) and dissolved oxygen (DO) dynamics. The temporal partitioning increased the predictive performances of the best MNLR models of diurnal DO by 45% and nocturnal DO by 4%, relative to the best diel MNLR model of diel DO (r(adj)(2) = 68.8%). The ANN-based predictions had a higher predictive power than the MNLR-based predictions for both chl-a and DO except for diurnal DO dynamics. The best ANNs based on independent validations were multilayer perceptron (MLP) for diel chl-a, generalized feedforward (GFF) for diurnal and nocturnal chl-a, MLP for diel DO, GFF for diurnal DO, and MLP for nocturnal DO