Hearing Evaluation in Solid Waste Workers

Introduction: Hearing loss at work is currently considered the most common cause of permanent hearing loss in adults and one of the most important health problems with economic and psychosocial consequences. The present study has the aim to investigate the prevalence and the determinants of hearing loss among electro production workers. Material and methods: Eight-three (83) solid waste workers underwent audiometric test in the facilities of the Integrated Solid Waste Management Facility (OEDA). For the assessment of hearing, the findings of the audiometers were evaluated, first with the performance of the diagnosis on the pathological findings and then with the use of diagnostic criteria (NIOSH, OYDOS) and includes occupational history, otoscopy and audiogram. Findings: Statistical analysis has shown that 23% of solid waste workers had sensorineural hearing loss located mainly at 4000 Hz. Multivariate analysis confirmed that the intensity of occupational exposure to noise appears to be the strongest predictor of noise-induced hearing loss (p=0.02326) followed by the years of work (p=0.02728). Particularly, the analysis with the NIOSH criterion (probability of having a positive NIOSH criterion in at least 1 of both ears) increased by 1.33 times/year or 32.84%/year on average. Finally, no univariate statistically significant associations were found with any of the two criteria and smoking, BMI, hypertension or tinnitus Estimating exposure through self-reported data is not sufficient and accurate and in fact workers who are exposed to higher risk measures tend to underestimate the risk. Conclusion: Our findings indicate that solid waste workers are occupationally exposed to high levels of noise, and present high rates of noise-induced hearing loss (NIHL). It is necessary to estimate the noise exposure with appropriate measurements in the work environment (individual sound exposure of employees and environmental measurements in the workplace) and take appropriate measures.                                        &nbsp

Gene replacement therapy in two Golgi-retained CMT1X mutants before and after the onset of demyelinating neuropathy

X-linked Charcot-Marie-Tooth disease type 1 (CMT1X) is a demyelinating neuropathy resulting from loss-of-function mutations affecting the GJB1/connexin 32 (Cx32) gene. We previously showed functional and morphological improvement in Gjb1-null mice following AAV9-mediated delivery of human Cx32 driven by the myelin protein zero (Mpz) promoter in Schwann cells. However, CMT1X mutants may interfere with virally delivered wild-type (WT) Cx32. To confirm the efficacy of this vector also in the presence of CMT1X mutants, we delivered AAV9-Mpz-GJB1 by lumbar intrathecal injection in R75W/Gjb1-null and N175D/Gjb1-null transgenic lines expressing Golgi-retained mutations, before and after the onset of the neuropathy. Widespread expression of virally delivered Cx32 was demonstrated in both genotypes. Re-establishment of WT Cx32 function resulted in improved muscle strength and increased sciatic nerve motor conduction velocities in all treated groups from both mutant lines when treated before as well as after the onset of the neuropathy. Furthermore, morphological analysis showed improvement of myelination and reduction of inflammation in lumbar motor roots and peripheral nerves. In conclusion, this study provides proof of principle for a clinically translatable gene therapy approach to treat CMT1X before and after the onset of the neuropathy, even in the presence of endogenously expressed Golgi-retained Cx32 mutants

A Wide Database for a Multicenter Study on Pneumocystis jirovecii Pneumonia in Intensive Care Units

Pneumocystis jirovecii pneumonia (PJP) is an opportunistic fungal infection that may affect patients with immunosuppression. In order to improve the diagnosis accuracy for PJP, facilitating the collection of data across Europe to reliably assess the performance of diagnostic tests for PJP is essential to improve the care of critically ill patients developing this severe condition. Such large data can be collected thanks to the contribution of several European hospitals in the compilation of a dedicated electronic Case Report Form (eCRF). The main focus of this work is to create an interface with high ergonomics both in the compilation and in the subsequent validation of the records

On the use of polymer gels for assessing the total geometrical accuracy in clinical Gamma Knife radiosurgery applications

The nearly tissue equivalent MRI properties and the unique ability of registering 3D dose distributions of polymer gels were exploited to assess the total geometrical accuracy in clinical Gamma Knife applications, taking into account the combined effect of the unit’s mechanical accuracy, dose delivery precision and the geometrical distortions inherent in MR images used for irradiation planning. Comparison between planned and experimental data suggests that the MR-related distortions due to susceptibility effects dominate the total clinical geometrical accuracy which was found within 1 mm. The dosimetric effect of the observed sub-millimetre uncertainties on single shot GK irradiation plans was assessed using the target percentage coverage criterion, and a considerable target dose underestimation was found

Holographic Kondo Model in Various Dimensions

We study the addition of localised impurities to U(N) Supersymmetric Yang-Mills theories in (p+1)-dimensions by using the gauge/gravity correspondence. From the gravity side, the impurities are introduced by considering probe D(8-p)-branes extendingalong the time and radial directions and wrapping an (7-p)-dimensional submanifold of the internal (8-p)-sphere, so that the degrees of freedom are point-like from the gauge theory perspective. We analyse both the configuration in which the branes generate straight flux tubes -corresponding to actual single impurities - and the one in which connected flux tubes are created- corresponding to dimers. We discuss the thermodynamics of both the configurations and the related phase transition. In particular, the specific heat of the straight flux-tube configuration is negative for p<3, while it is never the case for the connected one. We study the stability of the system by looking at the impurity fluctuations. Finally, we characterise the theory by computing one- and two-point correlators of the gauge theory operators dual to the impurity fluctuations. Because of the underlying generalised conformal structure, such correlators can be expressed in terms of an effective coupling constant (which runs because of its dimensionality) and a generalised conformal dimension.Comment: 56 pages, 3 figures; v2: typos correcte

A methodology for assessing and improving the total geometric accuracy in gamma knife radiosurgery

The purpose of the study is to present an end-to-end experimental procedure, based on a polymer gel phantom, capable of assessing the total geometric uncertainty in GK radiosurgery applications, in which MR images are solely used for both target delineation and registration of patient image coordinates to the Leksell space. As a result the study aims to propose a time-efficient method, based on corresponding polymer gel results, which considerably improves the geometric accuracy in GK treatment delivery

New reflection matrices for the U_q(gl(m|n)) case

We examine super symmetric representations of the B-type Hecke algebra. We exploit such representations to obtain new non-diagonal solutions of the reflection equation associated to the super algebra U_q(gl(m|n)). The boundary super algebra is briefly discussed and it is shown to be central to the super symmetric realization of the B-type Hecke algebraComment: 13 pages, Latex. A few alterations regarding the representations. A reference adde

Management of KPC-Producing Klebsiella pneumoniae Infections

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas