Laparoscopic Nephrectomy in Patients Undergoing Hemodialysis Treatment

With an experienced laparoscopic team of surgeons, laparoscopic nephrectomy may be performed safely

Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: A single-blind randomized clinical trial

BACKGROUND: Current knowledge on the ideal local anesthetic concentration for the ultrasound-guided transversus abdominis plane block (TAPB) in pediatrics is scarce. The purpose of this study is to compare the efficacy of US-guided TAPB at two different concentrations of bupivacaine in pediatrics undergoing unilateral inguinal hernia repair. METHODS: After random allocation, 74 children aged 1-8 were randomized to receive US-guided TAPB by using 1 mg.kg RESULTS: Sixty-four children were recruited for the study. Postoperative pain scores were equal between the two groups. There was no need for a rescue analgesic in any group after the postoperative 6 CONCLUSION: TAPB using 1 mg.kg TRIAL REGISTRATION: This trial was retrospectively registered at Clinicaltrals.gov , NCT04202367

Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

Background: Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multicenter, two-arm, international randomized controlled trial. In total, 2013 obese patients with body mass index ≥35 kg/m2 scheduled for at least 2 h of surgery under general anesthesia and at intermediate to high risk for PPCs will be included. Patients are ventilated intraoperatively with a low tidal volume of 7 ml/kg (predicted body weight) and randomly assigned to PEEP of 12 cmH2O with lung recruitment maneuvers (high PEEP) or PEEP of 4 cmH2O without recruitment maneuvers (low PEEP). The occurrence of PPCs will be recorded as collapsed composite of single adverse pulmonary events and represents the primary endpoint. Discussion To our knowledge, the PROBESE trial is the first multicenter, international randomized controlled trial to compare the effects of two different levels of intraoperative PEEP during protective low tidal volume ventilation on PPCs in obese patients. The results of the PROBESE trial will support anesthesiologists in their decision to choose a certain PEEP level during general anesthesia for surgery in obese patients in an attempt to prevent PPCs. Trial registration ClinicalTrials.gov identifier: NCT02148692. Registered on 23 May 2014; last updated 7 June 2016. Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1929-0) contains supplementary material, which is available to authorized users

Ruşeym yağının depolama stabilitesinin kapsüllenerek arttırılması.

Wheat germ oil is a rich source of omega 3 and omega 6-fatty acids, octacosanol and tocopherol which has vitamin E activity. Due to these properties it is very beneficial for health but it is prone to oxidation in free form. Encapsulation provides protection of food ingredients from environmental stresses and increases the stability and functionality of the ingredient, which makes it possible to be used in functional foods. The main objective of this study was to encapsulate wheat germ oil and to investigate its physicochemical properties and stabilities during storage. In encapsulation, aqueous solutions of maltodextrin (MD), gum arabic (GA), whey protein concentrate (WPC), chitosan (CS) and sodium caseinate (NaCa) at different concentrations were used as wall material. Core to coating ratio was constant as 1:8.The effects of different homogenization techniques (ultrasonication (US), high speed blending by silent crusher (SC) and microfluidization (MF)) on particle size distributions of emulsions and efficiency of microcapsules were investigated. The effect of different treatment passes in MF was also studied. In addition, the capsules prepared at the optimum conditions were studied for their storage stability by determining totox value and α tocopherol concentration during storage at 15°C and 45°C at 33.3% RH and 31.10% RH, respectively. NaCa was found to have better encapsulation properties than CS, WPC and GA in encapsulation of wheat germ oil. The SC and MF techniques were better in the formation of stable emulsions as compared to US. The change in treatment passes of MF did not have significant effect on encapsulation efficiencies; on the other hand, the increase in treatment passes decreased particle size of the emulsions. When storage temperature was 15°C, even the non-encapsulated oil was stable to oxidation. Storage stability analyses showed that rate of oxidation of fresh oil was higher than that of encapsulated oil stored at 45°C and microcapsules could maintain their stability for 20 days.M.S. - Master of Scienc

FEN BİLİMLERİ ENSTİTÜSÜ/LİSANSÜSTÜ TEZ PROJESİ

RUŞEYM YAĞININ DEPOLAMA STABİLİTESİNİN KAPSÜLLENENEREK ARTTIRILMAS