The role of sialoadenectomy and epýdermal growth factor (EGF) in skin development

In this study, the effect of epidermal growth factor (EGF) on skin development was investigated. A total of 24 adult female Spraque-Dawley rats were used in the study. The rats were divided into 3 equal groups as control, sialoadenectomy (SX) and sialoadenectomy+epidermal growth factor (SX+EGF). Sialoadenectomy was performed on the other groups except control. After a 21-day recovery period, subjects were made to mate. SX+EGF group rats were also given 12.5 ìg/day EGF for each animal orally in the 16, 17th, 18th and 19th days of pregnancy. After pregnancy, the offsprings obtained were grown until the 28th day. All 28-day-old offsprings in all groups were weighed and sacrificed. Skin samplesfrom interscapular region were examined under light and electron microscope. In light and electron microscopy, skin sections of SX group, atrophy in epiderm, hyperkeratosis, decrease in hair follicles and sebaceous glands, along with local thinning of basal membrane, hemidesmosome loss and necrotic cells were seen. In skin sections of SX+EGF group, the view was similar to controls. As a result, epidermal growth factor was concluded to have an important role in skin development

Our First Experience on Percutaneous Transvenous Mitral Commissurotomy (PTMC): Case Report

Rheumatic heart disease remains a significant healt problem especially in devaloping countries. In rheumatic heart disease, mitral valve is affected in nearly all cases; mitral stenosis is the most common lesion. Percutaneous Transvenous Mitral Commissurotomy (PTMC) is an important tool in the treatment of rheumatic mitral stenosis. In this study, our first PTMC case is presented, and the PTMC indications and the comparison of patients underwent PTMC with those patients underwent surgical intervention is discussed with the literature

Comparison of Genial Tubercule Anatomy Based on Age and Gender

Objective: In our study, it was aimed to determine whether there were differences in genial tubercle dimensions depending on age and gender.Methods: In this study, 220 cone beam computed tomography (CBCT) images of patients (110 female and 110 male) between the ages of 20-80 years were obtained from the archive of İzmir Katip Çelebi University Faculty of Dentistry. All patients were divided into decade groups according to their age, and each decade group was divided into two subgroups according to gender. The genial tubercle was defined radiologically using axial, coronal and sagittal sections as well as 3D reconstruction image with NNT software program. Sagittal, vertical and horizontal dimensions of the genial tubercle were measured and statistically analyzed.Results: There was a weak negative correlation between age groups and vertical values (r=-0.142; p=0.036) whereas the correlation coefficients between age groups and sagittal and horizontal values were not statistically significant (r=-0.043; p=0.530 and r=-0.039; p=0.563). There was a strong positive correlation between vertical and sagittal values in men (r=0.705, p<0.001) and women (r=0.714, p<0.001) in the whole group. There was a weak positive correlation between horizontal and sagittal, horizontal and vertical values in men (r=0.362, p<0.001; r=0.231, p<0.001) and women (r=0.304, p<0.001; r=0.257, p=0.007) in the whole group.Conclusion: The vertical and horizontal dimensions of genial tubercle of men were higher than that of women. As the age of the patients increased, a decrease in the vertical values of the genial tubercle was observed

COVID 19 Küresel Salgınına Genel Bakış

Kaynakça var

Evaluation of facial soft tissues by stereophotogrammetry method in patients with obstructive sleep apnoea: a morphological study

Background: We aimed to use the “SomnoMed MAS” device, which brings the mandible forward in obstructive sleep apnoea syndrome patients due to mandibular retrognathia, and to examine its effects on facial soft tissues by stereophotogrammetry (3dMD) method. Materials and methods: Thirty-one patients with a mean age of 44 years and 6 months were included in the study. SomnoMed MAS, one of the splint appliances that position the mandible in front, was applied to all patients and the changes in facial soft tissues were examined by overlapping the images taken at different times with the 3dMD face system. The obtained data were analysed statistically and the level of statistical significance was determined as p ≤ 0.05. Results: Mouth width decreased statistically during T0–T1 period. In T0–T2 period, while crista philtri and labiale inferius points moved backwards, Mouth width, nose width decreased and nasal base width increased. In the T0–T3 period, nasal base width increased statistically, the philtrum width and the mouth width decreased, and the soft tissue nasion point came to the fore. Conclusions: Splint treatment, which positions the mandible in front in adult obstructive sleep apnoea syndrome patients, affected the middle and lower facial soft tissues with the forward and downward translational movement of the lower jaw

Bionator ve Forsus uygulanan hastalarda dentofasiyal değişimlerin incelenmesi

Amaç: Bu çalışmanın amacı Sınıf II div 1 vakalarda uygulanan Bionator (B) ve Forsus (F) apareylerinin dentofasiyal sisteme olan etkilerini karşılaştırmaktır. Gereç ve Yöntem: Mandibular retrognatiye sahip ve pubertal gelişim dönemindeki 40 hasta iki gruba ayrıldı. Grup 1'e Bionator apareyi (15 kadın, 5 erkek), Grup 2'ye Forsus apareyi (9 kadın, 11 erkek) uygulandı. Her iki grupta da fonksiyonel aparey kullanımından önce ve sonra sefalometrik filmler alındı. Tedavi uygulanmayan mandibular retrognatiye sahip 20 hastanın sefalometrik kayıtları kontrol grubunun oluşturulmasında kullanıldı. Sefalometrik verilerin karşılaştırılmasında ANOVA ve Tukey HSD post-hoc testi kullanıldı. Bulgular: Bionator ve Forsus kullanımı sonucunda SNA açısında azalma bulundu. Forsus grubundaki azalma anlamlı düzeyde bulundu. Her iki grupta da SNB açısında anlamlı bir artış ve ANB açısında anlamlı bir azalma bulunmuştur (

Metal Bioavailability in the Sava River Water

Metals present one of the major contamination problems for freshwater systems, such as the Sava River, due to their high toxicity, persistence, and tendency to accumulate in sediment and living organisms. The comprehensive assessment of the metal bioavailability in the Sava River encompassed the analyses of dissolved and DGT-labile metal species of nine metals (Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn) in the river water, as well as the evaluation of the accumulation of five metals (Cd, Cu, Fe, Mn, and Zn) in three organs (liver, gills, and gastrointestinal tissue) of the bioindicator organism, fish species European chub (Squalius cephalus L.).This survey was conducted mainly during the year 2006, in two sampling campaigns, in April/May and September, as periods representative for chub spawning and post-spawning. Additionally, metal concentrations were determined in the intestinal parasites acanthocephalans, which are known for their high affinity for metal accumulation. Metallothionein concentrations were also determined in three chub organs, as a commonly applied biomarker of metal exposure. Based on the metal concentrations in the river water, the Sava River was defined as weakly contaminated and mainly comparable with unpolluted rivers, which enabled the analyses of physiological variability of metal and metallothionein concentrations in the chub organs, as well as the establishment of their constitutive levels

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe