Differences in Neuromuscular Adaptations After Two Weeks of Conventional vs Blood Flow Restriction Resistance Training

PURPOSE: The purpose of the study was to determine the neuromuscular changes in the rectus femoris (RF) muscle as measured by electromyography (EMG) following short-term resistance training with and without blood flow restriction (BFR). METHODS: 12 males (age = 27.4 ± 6.3 years; height = 171 ± 7 cm; weight = 79.8 ± 13.2 kg) performed six sessions of lower body unilateral resistance training using a leg extension machine. The leg on which BFR was applied was determined through randomization leg dominance Each training session consisted of unilateral knee extensions with and without blood flow restriction. Electromyography data was recorded for each participant during two isometric maximum voluntary contractions (MVC) and two isokinetic knee extension tests (180°/s and 60°/s) using a Biodex System 4 Pro™. EMG was recorded from the RF during these tests. Resistance training consisted of six non-consecutive sessions of knee extension exercises performed in a time frame of two weeks. For the BFR group, subjects trained for a total of four sets (30, 15, 15, 15) at an intensity of 20% 1RM. The contralateral limb was trained with two sets of 11 repetitions at an intensity of 70% 1RM without BFR. The volume of exercises was similar for both conditions. RESULTS: No condition*time interactions or condition and time main effects were observed for root mean square (RMS), mean RMS, yMax, and median frequency (MDF) in both MVC and isokinetic 180°/s and 60°/s (p\u3e0.05). CONCLUSIONS: Both training conditions resulted in insignificant changes and there was no significant difference found between time points. It could be concluded that this was not enough time or stimulus to note major differences across modalities in relation to neuromuscular adaptations of the RF as measured by EMG. Further studies should investigate the effects of higher volume load on neuromuscular adaptations

The volume fraction of brain ventricles to total brain volume: a computed tomography stereological study

This study has been designed to estimate the volume fraction of the brain ventricles volume to total brain volume and to correlate them with gender and age in normal subjects. Cranial computed tomography (CT) images of 80 normally evaluated subjects (five female and five male for each decade) were selected from 1,073 CT examinations. The volumes of total brain, cerebral aqueduct, fourth, third, and lateral ventricles and their ratios were estimated using the Cavalieri method and volume fraction-stereological methods. The ratio of total brain ventricle volume to total brain volume was comparable between the two genders (p > 0.05, independent t test). Mean volume fraction of total ventricle volume to total brain volume was found to be 1.21% in the first and 3.37% in the last decades. Mean volume fraction was found to increase significantly with age (p < 0.01, r = 0.630, Pearson). In conclusion, the mean percentage of total ventricle volume within the total brain volume was found to be 2%. We demonstrated the volume fraction of total ventricle to total brain in normal subjects. Total ventricle volume to total brain volume fractions can be important tools in determining ventricle volumes, which denote variability in some diseases (Alzheimer, schizophrenia, neurodegenerative disorders, etc.) and can be estimated by stereological methods. (Folia Morphol 2010; 69, 4: 193-200

Acute Effects of Aerobic Exercise with Blood Flow Restriction on Pulse Wave Velocity in Females

PURPOSE: To investigate the acute effects of a 20-minute walk/run at 40% VO2 with and without blood flow restriction on pulse wave velocity (PWV). METHODS: Seventeen female subjects, between the ages of 18 and 40, signed informed consent and were familiarized with the study protocol, on the same day measurements were assessed: height, weight, body composition, and thigh circumference. Followed by each subject performing the Bruce Protocol on a treadmill. Subjects were asked to come back to the lab hydrated and 8 hours fasted on two different days (separated by at least 48 hours). After reaching hydration, participants were asked to lie down in the supine position for a minimum of 10 minutes and baseline hemodynamics and measurement of PWV using SphygmoCor® CPV Pulse Wave Analyzer. The sites tested were carotid to radial (C-R), carotid to femoral (C-F), and femoral to posterior tibial (F-PT). The randomized testing sessions consisted of two 20-minute walk/run sessions at 40% VO2 intensity with BFR cuffs inflated (BFR), and the BFR cuffs un-inflated (CON). Tightness of the cuffs was set at 55-60 mmHg for BFR, and the cuffs were placed snug enough that they don’t move during exercise for the CON session. The final cuff pressures were achieved by starting at 120 mmHg and increasing progressively by 20 mmHg with 10 s rest in between increments. Upon completion of exercise, post exercise PWV was assessed at immediately, 15, 25, and 45 minutes. RESULTS: No condition*time interaction or condition and time main effects were observed for C-R and C-F sites (p\u3e0.05). There were no significant condition*time interaction or time main effect for the F-PT site (p\u3e0.05), but a significant condition main effect was detected at the 15 minute mark post exercise following the BFR session (p\u3c.01). CONCLUSION: The results suggest that the BFR session resulted in an improved arterial compliance at the F-PT site. This may have been caused by the increased shear stress from blood pooling during the BFR session resulting in a greater release of nitric oxide therefore vasodilation in the lower body. There may be a practical application of using this combination of exercise and settings to help improve cardiovascular health. Since this was an acute study, future training studies should look at the chronic effects on pulse wave velocity using these settings

Mycobacterial infection of intraparenchymal bronchogenic cysts

Bronchogenic cysts (BCs) may rarely cause some interesting and unusual complications. Although infection is a common complication of BCs, there are only two patients with BC infected with mycobacterium in English literature. Two intraparencymal BCs infected with mycobacterium are presented here as unusual complications. Cystectomy was performed for the cysts. They were given antituberculosis treatment. No complication or recurrences were detected in follow up period. © 2006 Elsevier Ltd. All rights reserved

Effects of Dynamic and Isometric Vibration Exercises on Hemodynamics, Flexibility, and Stress Hormone Levels

PURPOSE: To investigate the acute effects of lower body dynamic (DYN) vs isometric (ISO) exercises on systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate (HR), flexibility using the sit and reach, and cortisol (COR) and amylase (AMY) levels measured pre and post exercise with different variations of frequency and amplitude on a power plate in pre-hypertensive females. METHODS: Nine females (age: 23.8 ± 5.1 yrs) performed the ISO and DYN control sessions with the power plate off and ISO and DYN exercises with a combination of low frequency/high amplitude (LF/HA) and high frequency/low amplitude (HF/LA). A 5-min warm-up at 3.0 mph on the treadmill occurred before testing. DYN exercises were performed from standing position to 120° for squat, 90° for lunge, and 90° for squat for a total of four sets for one-min with metronome set at 40 bpm. ISO exercises were performed at the knee angles mentioned previously. Subjects had a 30 sec rest in-between sets. Blood pressure (BP) and HR were recorded using an automated BP cuff pre, post, post 15-min, and post 30-min. Flexibility was recorded after the warm-up and post testing. The passive drool collection method was used to collect saliva to observe the changes in COR and AMY for a total of 1mL for each session before the warm up and post-exercise. Vials were then placed in the freezer to await analysis. RESULTS: There was a significant condition*time interaction (

Oxygen and Phosphorus Coordination Around Iron in Crystalline Ferric Ferrous Pyrophosphate and Iron-phosphate Glasses with UO₂ or Na₂O

Fe K-edge x-ray absorption fine-structure (XAFS) measurements were performed on glass samples of (Fe3O4)0.3(P2O5)0.7 with various amounts of Na2O or UO2. Near-edge and extended-XAFS regions are studied and comparisons are made to several reference compounds. We find that iron in the base glass is ~25% divalent and that the Fe2+ coordination is predominantly octahedral, while Fe3+ sites are roughly split between tetrahedral and octahedral coordinations. Also, we measure roughly one FeñOñP link per iron. Substitution of Na2O or UO2 up to 15 mo1% primarily affects the first FeñO shell. The results are compared to data from the related material Fe3(P2O7)2

Is there a gender difference in anatomic features of incisive canal and maxillary environmental bone?

Objectives The effect of gender on anatomic structures and various body systems were illustrated in the literature. The purpose of this study was to identify the influence of gender and tooth loss on incisive canal characteristics and buccal bone dimensions in the anterior maxilla. Materials and methods Computed tomographies ( CTs ) of 417 male and 516 female patients in four dental clinics were included in this study. The diameter and the length of the incisive canal; width and the length of the bone anterior to the canal; palatal bone length, root length, and root width of the central incisor teeth were measured and recorded from CT sections. Results Mean incisive canal length was 11.96 ± 2.73 mm and 10.39 ± 2.47 mm in men and women, respectively, ( P  < 0.05). In men, mean canal diameter was 2.79 ± 0.94 mm whereas in women it was 2.43 ± 0.85 mm and this difference was statistically significant ( P  < 0.05). Men had significant higher buccal bone dimensions (length and width of the bone anterior to the canal) than women. Absence of teeth in the anterior maxilla decreased incisive canal length and buccal bone dimensions; however, canal diameter remain unchanged. Conclusions Present results suggested a gender related differences in anatomic features of incisive canal and surrounding buccal bone. In addition, crestal canal diameter, buccal bone length, and thickness parameters might be different in distinct countries.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99051/1/clr2493.pd

Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma

Background: Basal cell carcinomas (BCCs) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of the NM23-H1, NDRG1, E-cadherin, RHOGDI2, CD82/KAI1, MKK4, and AKAP12 metastasis suppressor proteins in BCCs. Methods: A total of 96 BCC and 10 normal skin samples were included for the immunohistochemical study. Eleven frozen BCC samples were also studied by quantitative real time polymerase chain reaction (qRT-PCR) to detect the gene expression profile. Results: NM23-H1 was strongly and diffusely expressed in all types of BCC. Significant cytoplasmic expression of NDRG1 and E-cadherin was also detected. However, AKAP12 and CD82/KAI1 expression was significantly decreased. The expressions of the other proteins were somewhere between the two extremes. Similarly, qRT-PCR analysis showed down-regulation of AKAP12 and up-regulation of NM23-H1 and NDRG1 in BCC. Morphologically aggressive BCCs showed significantly higher cytoplasmic NDRG1 expression scores and lower CD82/KAI1 scores than non-aggressive BCCs. Conclusion: The relatively preserved levels of NM23-H1, NDRG1, and E-cadherin proteins may have a positive effect on the non-metastasizing features of these tumors. © 2014 The International Society of Dermatology

Relation of age and sex with carotid intima media thickness in healthy children

Background/aim: To investigate the age- and sex-associated carotid intima media thickness (cIMT) changes in healthy children to determine the age- and sex-specific normal range of values for childhood. Materials and methods: This study examined 91 healthy school-age children aged 7-15 years prospectively. Standardized sonographic cIMT measurements and analyses were performed. Body mass index and blood pressure were obtained, and atherosclerotic risk factors were investigated. Age- and sex-specific cIMT measurements for different age groups were calculated and the relation with sex was investigated. Results: Regarding the total study group, mean cIMT measurements for age groups 7-9, 10-12, and 13-15 years were 4.1 ± 0.5 mm, 4.4 ± 0.6 mm, and 4.6 ± 0.4 mm, respectively. cIMT did not differ between boys and girls in the same age group. Age related analyses showed significant variations among the age groups with positive correlation between cIMT and age. Conclusion: Our results suggest that age-related physiologic thickening of the carotid artery intima-media occurs not only in adults but also in children and that sex is not a factor for cIMT differences in childhood. © TÜBİTAK