The biology of toxoplasma

Thesis (M.A.)--Boston University This item was digitized by the Internet Archive

Health-related quality of life in patients with pulmonary arterial hypertension

BACKGROUND: Improved outcomes with expanding treatment options for patients with pulmonary arterial hypertension present the opportunity to consider additional end-points in approaching therapy, including factors that influence health-related quality of life. However, comparatively little is known about health-related quality of life and its determinants in patients with pulmonary arterial hypertension. METHODS: Health-related quality of life was evaluated in a cross sectional study of 155 outpatients with pulmonary arterial hypertension using generic and respiratory-disease specific measurement tools. Most patients had either World Health Organization functional Class II or III symptoms. Demographic, hemodynamic and treatment variables were assessed for association with health-related quality of life scores. RESULTS: Patients with pulmonary arterial hypertension suffered severe impairments in both physical and emotional domains of health-related quality of life. Patients with idiopathic ("primary") pulmonary arterial hypertension had the best, and those with systemic sclerosis the worst health-related quality of life. Greater six-minute walk distance correlated with better health-related quality of life scores, as did functional Class II versus Class III symptoms. Hemodynamic measurements, however, did not correlate with health-related quality of life scores. No differences in health-related quality of life were found between patients who were being treated with calcium channel antagonists, bosentan or continuously infused epoprostenol at the time of quality of life assessment. CONCLUSION: Health-related quality of life is severely impaired in patients with pulmonary arterial hypertension and is associated with measures of functional status. Specific associations with impaired health-related quality of life suggest potential areas for targeted intervention

Semiclassical Theory of Coulomb Blockade Peak Heights in Chaotic Quantum Dots

We develop a semiclassical theory of Coulomb blockade peak heights in chaotic quantum dots. Using Berry's conjecture, we calculate the peak height distributions and the correlation functions. We demonstrate that the corrections to the corresponding results of the standard statistical theory are non-universal and can be expressed in terms of the classical periodic orbits of the dot that are well coupled to the leads. The main effect is an oscillatory dependence of the peak heights on any parameter which is varied; it is substantial for both symmetric and asymmetric lead placement. Surprisingly, these dynamical effects do not influence the full distribution of peak heights, but are clearly seen in the correlation function or power spectrum. For non-zero temperature, the correlation function obtained theoretically is in good agreement with that measured experimentally.Comment: 5 color eps figure

Chaos in Quantum Dots: Dynamical Modulation of Coulomb Blockade Peak Heights

The electrostatic energy of an additional electron on a conducting grain blocks the flow of current through the grain, an effect known as the Coulomb blockade. Current can flow only if two charge states of the grain have the same energy; in this case the conductance has a peak. In a small grain with quantized electron states, referred to as a quantum dot, the magnitude of the conductance peak is directly related to the magnitude of the wavefunction near the contacts to the dot. Since dots are generally irregular in shape, the dynamics of the electrons is chaotic, and the characteristics of Coulomb blockade peaks reflects those of wavefunctions in chaotic systems. Previously, a statistical theory for the peaks was derived by assuming these wavefunctions to be completely random. Here we show that the specific internal dynamics of the dot, even though it is chaotic, modulates the peaks: because all systems have short-time features, chaos is not equivalent to randomness. Semiclassical results are derived for both chaotic and integrable dots, which are surprisingly similar, and compared to numerical calculations. We argue that this modulation, though unappreciated, has already been seen in experiments.Comment: 4 pages, 3 postscript figs included (2 color), uses epsf.st

The Deglaciation of Maine, USA

The glacial geology of Maine records the northward recession of the Late Wisconsinan Laurentide Ice Sheet, followed by development of a residual ice cap in the Maine-Québec border region due to marine transgression of the St. Lawrence Lowland in Canada. The pattern of deglaciation across southern Maine has been reconstructed from numerous end moraines, deltas and submarine fans deposited during marine transgression of the coastal lowland. Inland from the marine limit, a less-detailed sequence of deglaciation is recorded by striation patterns, meltwater channels, scattered moraines and waterlain deposits that constrain the trend of the ice margin. There is no evidence that the northern Maine ice cap extended as far south-west as the Boundary Mountains and New Hampshire border. Newly-obtained radiocarbon ages from marine and terrestrial ice-proximal environments have improved the chronology of glacial recession in Maine. Many of these ages were obtained by coring late-glacial sediments beneath ponds and lakes. Data from this study show that the state was deglaciated between about 14.5 and 11.0 ka BP (14C years). The coastal moraine belt in southern Maine was deposited by oscillatory ice-margin retreat during the cold pre-Bølling time. Rapid ice recession to northern Maine then occurred between 13 and 11 ka BP, during the warmer Bølling/Allerød chronozones. Radiocarbon-dated pond sediments in western and northern Maine show lithologic evidence of Younger Dryas climatic cooling and persistence of the northern ice cap into Younger Dryas time. A large discrepancy still exists between radiocarbon ages of deglaciation in coastal south-western Maine and the timing of ice retreat indicated by New England varve records in areas to the west. Part of this problem may stem from the uncertainty of reservoir corrections applied to the radiocarbon ages of marine organics

Hispanics/Latinos With Type 2 Diabetes Have Functional and Symptomatic Pulmonary Impairment Mirroring Kidney Microangiopathy: Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Type 2 diabetes mellitus (DM) has been associated with lung dysfunction, but this association has not been explored in Hispanics/Latinos. The relation between diabetic nephropathy and lung function and symptoms has not been explored

Asthma

Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICSs) represent the standard of care for the majority of patients. Combination ICS/long-acting beta2-agonists (LABA) inhalers are preferred for most adults who fail to achieve control with ICS therapy. Allergen-specific immunotherapy represents a potentially disease-modifying therapy for many patients with asthma, but should only be prescribed by physicians with appropriate training in allergy. Regular monitoring of asthma control, adherence to therapy and inhaler technique are also essential components of asthma management. This article provides a review of current literature and guidelines for the appropriate diagnosis and management of asthma