Do rBST-Free and Organic Milk Stigmatize Conventionally Produced Milk?

Producers are continually seeking to differentiate their products in the marketplace. A common approach is via labeling where differences in production methods are marketed. Yet, positive labeling for the new product has the potential to stigmatize the conventionally produced product by highlighting perceived problems with the product. The net economic result can be negative to producers as the conventional product that dominates the market is stigmatized by the new product that has little market share, and this leads to consumers decreasing their willingness to pay for the conventional product. This experimental research identifies this stigma effect in the case of milk, where the presentation of rBST-Free milk reduces consumers' willingness to purchase conventional milk.Demand and Price Analysis,

Identifying Significant Characteristics of Organic Milk Consumers: A CART Analysis of an Artefactual Field Experiment

The organic dairy category is one the fastest growing categories of organic production in the U.S. Organic milk consumers generally cite perceived health benefits and lower risk of food contamination, as well as perceived superior quality and low environmental impact of organic farming methods, as the major motivations for preference of organic over conventional milk. While the properties of organic milk that are valued by consumers are fairly well-known, there is more ambiguity regarding the demographic characteristics of the typical organic milk consumer. This research makes use of experimental data and utilizes a relatively novel non-parametric modeling approach, the CART analysis, in identifying how willingness to pay for organic milk varies with the demographic profile of experiment participants. A more traditional econometric approach utilizing a Tobit regression is also performed to compare the results of the two models. The study finds that perceived taste of organic milk and concern for the risk of consuming conventional milk are major factors that separate experiment participants into groups with high and low WTP for organic milk.Consumer/Household Economics,

Desarrollo de una plataforma digital para el giagnóstico del nivel de seguridad de la información basado en la norma ISO 27001

T1-2020Desarrollo de una plataforma digital para el diagnóstico del nivel de seguridad de la información basado en la norma ISO/IEC 27001. Esta tesis presenta el desarrollo de una plataforma digital para el diagnóstico del nivel de seguridad de la información basado en la norma ISO/IEC 27001, el cual tiene el objetivo de proporcionar un diagnóstico inicial a una empresa independientemente del rubro o nivel actual de seguridad de la información que tenga. Adicionalmente, la optimización del proceso considera que los resultados del diagnóstico serán claros, esto con el propósito de que se puedan llevar a cabo mejoras y reducir el riesgo que produce el no contar un plan de contingencia y/o mejora respecto a la seguridad de la información. En particular, la optimización del proceso consiste en el análisis de un gestor de información convencional y así lograr la propuesta de una plataforma personalizada para empresas que requieran estar normadas con la ISO/IEC 27001. Por lo tanto, se propone un sistema y proceso optimizado el cual será la base para el desarrollo de la plataforma digital. Como resultados preliminares, la reducción de elementos necesarios para un diagnóstico inicial del nivel de seguridad de la información promueve la simplicidad de la aplicación y por tanto, incrementa la posibilidad de aplicar la ISO/IEC 27001 a una mayor cantidad de usuarios, lo que significa que sus niveles de seguridad de la información ha incrementado.Maestri

Is There a Patient Profile That Characterizes a Patient With Adult Spinal Deformity as a Candidate for Minimally Invasive Surgery?

Study designRetrospective review.ObjectivesThe goal of this study was to evaluate the baseline characteristics of patients chosen to undergo traditional open versus minimally invasive surgery (MIS) for adult spinal deformity (ASD).MethodsA multicenter review of 2 databases including ASD patients treated with surgery. Inclusion criteria were age >45 years, Cobb angle minimum of 20°, and minimum 2-year follow-up. Preoperative radiographic parameters and disability outcome measures were reviewed.ResultsA total of 350 patients were identified: 173 OPEN patients and 177 MIS. OPEN patients were significantly younger than MIS patients (61.5 years vs 63.74 years, P = .013). The OPEN group had significantly more females (87% vs 76%, P = .006), but both groups had similar body mass index. Preoperative lumbar Cobb was significantly higher for the OPEN group (34.2°) than for the MIS group (26.0°, P < .001). The mean preoperative Oswestry Disability Index was significantly higher in the MIS group (44.8 in OPEN patients and 49.8 in MIS patients, P < .011). The preoperative Numerical Rating Scale value for back pain was 7.2 in the OPEN group and 6.8 in the MIS group preoperatively, P = .100.ConclusionsPatients chosen for MIS for ASD are slightly older and have smaller coronal deformities than those chosen for open techniques, but they did not have a substantially lesser degree of sagittal malalignment. MIS surgery was most frequently utilized for patients with an sagittal vertical axis under 6 cm and a baseline pelvic incidence and lumbar lordosis mismatch under 30°

Broadband amplitude squeezing in a periodically poled KTiOPO_4 waveguide

We generated -2.2 dB of broadband amplitude squeezing at 1064 nm in a periodically poled KTiOPO_4 (PPKTP) waveguide, by coupling of the fundamental and second harmonic continuous-wave fields. This is the largest amount of squeezing obtained to date in a KTP waveguide, limited by propagation losses. This result paves the way for further improvements by use of lower-loss buried ion-exchanged waveguides.Comment: 3 pages, 2 figures, submitted for publicatio

Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases

Catalysis of human phosphoglycerate mutase is dependent on a 2,3-bisphosphoglycerate cofactor (dPGM), whereas the nonhomologous isozyme in many parasitic species is cofactor independent (iPGM). This mechanistic and phylogenetic diversity offers an opportunity for selective pharmacologic targeting of glycolysis in disease-causing organisms. We previously discovered ipglycermide, a potent inhibitor of iPGM, from a large combinatorial cyclic peptide library. To fully delineate the ipglycermide pharmacophore, herein we construct a detailed structure–activity relationship using 280 substituted ipglycermide analogs. Binding affinities of these analogs to immobilized Caenorhabditis elegans iPGM, measured as fold enrichment relative to the index residue by deep sequencing of an mRNA display library, illuminated the significance of each amino acid to the pharmacophore. Using cocrystal structures and binding kinetics, we show that the high affinity of ipglycermide for iPGM orthologs, from Brugia malayi, Onchocerca volvulus, Dirofilaria immitis, and Escherichia coli, is achieved by a codependence between (1) the off-rate mediated by the macrocycle Cys14 thiolate coordination to an active-site Zn2+ in the iPGM phosphatase domain and (2) shape complementarity surrounding the macrocyclic core at the phosphotransferase–phosphatase domain interface. Our results show that the high-affinity binding of ipglycermide to iPGMs freezes these structurally dynamic enzymes into an inactive, stable complex

Muscle Loss Is Associated with Overall Survival in Patients with Metastatic Colorectal Cancer Independent of Tumor Mutational Status and Weight Loss

Background: Survival in patients with metastatic colorectal cancer (mCRC) has been associated with tumor mutational status, muscle loss, and weight loss. We sought to explore the combined effects of these variables on overall survival. Materials and methods: We performed an observational cohort study, prospectively enrolling patients receiving chemotherapy for mCRC. We retrospectively assessed changes in muscle (using computed tomography) and weight, each dichotomized as >5% or ≤5% loss, at 3, 6, and 12 months after diagnosis of mCRC. We used regression models to assess relationships between tumor mutational status, muscle loss, weight loss, and overall survival. Additionally, we evaluated associations between muscle loss, weight loss, and tumor mutational status. Results: We included 226 patients (mean age 59 ± 13 years, 53% male). Tumor mutational status included 44% wild type, 42% RAS-mutant, and 14% BRAF-mutant. Patients with >5% muscle loss at 3 and 12 months experienced worse survival controlling for mutational status and weight (3 months hazard ratio, 2.66; p 5% muscle loss with BRAF-mutational status at 6 and 12 months. Weight loss was not associated with survival nor mutational status. Conclusion: Increased muscle loss at 3 and 12 months may identify patients with mCRC at risk for decreased overall survival, independent of tumor mutational status. Specifically, >5% muscle loss identifies patients within each category of tumor mutational status with decreased overall survival in our sample. Our findings suggest that quantifying muscle loss on serial computed tomography scans may refine survival estimates in patients with mCRC. Implications for practice: In this study of 226 patients with metastatic colorectal cancer, it was found that losing >5% skeletal muscle at 3 and 12 months after the diagnosis of metastatic disease was associated with worse overall survival, independent of tumor mutational status and weight loss. Interestingly, results did not show a significant association between weight loss and overall survival. These findings suggest that muscle quantification on serial computed tomography may refine survival estimates in patients with metastatic colorectal cancer beyond mutational status

The use of standardized patients for mock oral board exams in neurology: a pilot study

BACKGROUND: Mock oral board exams, fashioned after the live patient hour of the American Board of Psychiatry and Neurology exam, are commonly part of resident assessment during residency training. Exams using real patients selected from clinics or hospitals are not standardized and do not allow comparisons of resident performance across the residency program. We sought to create a standardized patient mock oral board exam that would allow comparison of residents' clinical performance. METHODS: Three cases were created and then used for this mock oral boards exercise utilizing trained standardized patients. Residents from the University of Cincinnati and Indiana University participated in the exam. Residents were scored by attending physician examiners who directly observed the encounter with the standardized patient. The standardized patient also assessed each resident. A post-test survey was administered to ascertain participant's satisfaction with the examination process. RESULTS: Resident scores were grouped within one standard deviation of the mean, with the exception of one resident who was also subjectively felt to "fail" the exam. In exams with two faculty "evaluators", scores were highly correlated. The survey showed satisfaction with the examination process in general. CONCLUSION: Standardized patients can be used for mock oral boards in the live patient format. Our initial experience with this examination process was positive. Further testing is needed to determine if this examination format is more reliable and valid than traditional methods of assessing resident competency

The (in)compatibility of identities: Understanding gender differences in work-life conflict through the fit with leaders

This is the final version. Available on open access from Wiley via the DOI in this recordData availability statement: The data that support the findings of these studies are available from the corresponding author upon request.Women’s concerns about work-life balance are cited as a key factor underlying their continued underrepresentation in particular domains and roles. This gendered pattern is often attributed to factors in the home, such as women’s disproportionate share of domestic work and childcare responsibilities. We offer an additional explanation that focuses on workplace identities. Across four studies we demonstrate that perceptions of work-life balance are not only a matter of balancing time, but also a matter of balancing identity, and that the availability of attainable leaders plays a key role in determining these processes. More specifically, a survey study (Study 1, N=1223) among participants working in a historically male-dominated profession shows that gender differences in work-life balance perceptions are, in part, explained by women’s perceived lack of fit with leaders and, in turn, their perceptions of incompatibility between who they are at home and who they are at work. In Studies 2 (N=207), 3a (N=209), and 3b (N=191) we demonstrate that gender differences in anticipated work-life balance can be ameliorated through exposure to attainable female leaders. These findings have implications for organisations that seek to recruit and retain women and demonstrate that issues of identity are crucial for facilitating work-life balance.British AcademyEuropean CommissionDutch Science Foundatio

Universal WBC reduction

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75583/1/j.1537-2995.2000.40060751.x.pd