3 research outputs found
Successful management of severe intrahepatic cholestasis of pregnancy: report of a first Japanese case
Microdissection testicular sperm extraction in five Japanese patients with nonâmosaic Klinefelter's syndrome
Abstract Cases Microdissection testicular sperm extraction (microâTESE) was performed on five Japanese men with nonâmosaic Klinefelter's syndrome (KS) and nonâobstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases where spermatozoa could be acquired. Also encountered was a man with nonâmosaic KS with the partial deletion of azoospermia factor (AZF)b. Because this is rare, it is reported in detail in the context of the previous literature. This case series describes the first experience of microâTESE by gynecologists in the current department. Outcome The egg collection date was adjusted to the microâTESE day by using the modified ultraâlong method. Intracytoplasmic sperm injection (ICSI) was implemented for two men whose spermatozoa were acquired by microâTESE, with these progressing to the blastocyst stage. Subsequently, one case conceived after the transfer of fresh embryos and a healthy baby was delivered. However, spermatozoa could not be retrieved from the man with nonâmosaic KS who was harboring the partial deletion of AZFb. Conclusion These findings suggest that ovulation induction by using the modified ultraâlong method with microâTESE and ICSI on the same day represents an effective treatment option for men with nonâmosaic KS. As there are cases where AZF deletion is recognized among patients with nonâmosaic KS, screening before microâTESE is strongly recommended