Investigating the Distinctions in Physical Well-being and Life Satisfaction between Women with Hypothyroidism and Healthy Individuals: A Focus on Rehabilitation School Attendees

Introduction: Hypothyroidism, characterized by an underactive thyroid, is a prevalent condition often accompanied by metabolic changes and goiter. Despite successful treatment, previous research suggests that the quality of life for many patients may be reduced. This study aims to investigate the quality of life in women with hypothyroidism, specifically those treated with levothyroxine, by comparing them to a control group. Materials and Methods: A case-control study involving 61 women aged 18 to 65 with hypothyroidism treated with levothyroxine was conducted. The World Health Organization Quality of Life-26 questionnaire (WHO/QOL-BREF) was used to assess health-related quality of life (HRQOL). The collected data from the WHO/QOL-BREF questionnaires were compared between the patient group and a healthy control group. Serum T4 and TSH levels were also measured in both groups. Results: The average WHO/QOL-BREF score for the patient group was 84.7±10.9, while the healthy control group scored 88.3±12.1. Although there was no significant difference in overall HRQOL, significant differences were observed between the two groups in the physical health (13.75±2.54 for patients and 14.9±2.1 for healthy individuals) and psychological health domains (11.84±2.69 for patients and 13.2±2.3 for healthy individuals). No significant differences were found in the social and environmental health domains (social: patients 12.51±3.15, healthy individuals 12.1±3.4; environmental: patients 13.62±1.75, healthy individuals 13.3±2.2) (P-value=0.74). Conclusion: In this study, significant differences were observed only in the physical and psychological health domains of women with treated hypothyroidism, with their average scores being lower than those of healthy individuals. However, no significant differences were found in the social and environmental health domains between the two groups

Studies in anthraquinone: Synthesis of 3-amino/3-alkyl-2,4-dioxo-1,2,3,4- tetrahydropyrimido[4,5-a]anthraquinone derivatives

1290-129

Studies in anthraquinones: Preparation of 2-substituted-pyrimido anthraquinones and related fused 1,2,4-triazolo, tetrazolo and pyrazolino derivatives

651-65

Studies in anthraquinones: Preparation of l-aminoanthraquinone-2-carbohydrazide, 1,3,4-oxidiazoles, pyrazoles, pyrimidines and phthalazines

778-78

Simple methodology for the quantitative analysis of fatty acids in human red blood cells

In the last years, there has been an increasing interest in evaluating possible relations between fatty acid (FA) patterns and the risk for chronic diseases. Due to the long life span (120 days) of red blood cells (RBCs), their FA profile reflects a longer term dietary intake and was recently suggested to be used as an appropriate biomarker to investigate correlations between FA metabolism and diseases. Therefore, the aim of this work was to develop and validate a simple and fast methodology for the quantification of a broad range of FAs in RBCs using gas chromatography with flame ionization detector, as a more common and affordable equipment suitable for biomedical and nutritional studies including a large number of samples. For this purpose, different sample preparation protocols were tested and compared, including a classic two-step method (Folch method) with modifications and different one-step methods, in which lipid extraction and derivatization were performed simultaneously. For the one-step methods, different methylation periods and the inclusion of a saponification reaction were evaluated. Differences in absolute FA concentrations were observed among the tested methods, in particular for some metabolically relevant FAs such as trans elaidic acid and eicosapentaenoic acid. The one-step method with saponification and 60 min of methylation time was selected since it allowed the identification of a higher number of FAs, and was further submitted to in-house validation. The proposed methodology provides a simple, fast and accurate tool to quantitatively analyse FAs in human RBCs, useful for clinical and nutritional studies.This work received financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT, Fundação para a Ciência e Tecnologia) through project PTDC/SAU-ENB/116929/2010 and EXPL/EMS-SIS/2215/2013. ROR acknowledges PhD scholarship SFRH/BD/97658/2013 attributed by FCT (Fundação para a Ciência e Tecnologia).info:eu-repo/semantics/publishedVersio