A New Collaborative Digital Social Space

To understand the web design principles in a Digital Social Space (DSS) that can attract multiple national cultures into one SNS platform, Internet communication users from different cultures were chosen as targets for this investigation, using questionnaires to collect user preferences on a digital social space. Social network sites (SNS) evolved within a short time into a popular Internet-mediated tool that is being used worldwide on a daily basis. Though presumptions in interaction through SNS create bias in web design that does not translate well into foreign cultures. Results revealed that different culture groups have different understandings of online communication tools in a Digital Social Space (DSS)

Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology

Abstract Background In many protein-protein interaction (PPI) networks, densely connected hub proteins are more likely to be essential proteins. This is referred to as the "centrality-lethality rule", which indicates that the topological placement of a protein in PPI network is connected with its biological essentiality. Though such connections are observed in many PPI networks, the underlying topological properties for these connections are not yet clearly understood. Some suggested putative connections are the involvement of essential proteins in the maintenance of overall network connections, or that they play a role in essential protein clusters. In this work, we have attempted to examine the placement of essential proteins and the network topology from a different perspective by determining the correlation of protein essentiality and reverse nearest neighbor topology (RNN). Results The RNN topology is a weighted directed graph derived from PPI network, and it is a natural representation of the topological dependences between proteins within the PPI network. Similar to the original PPI network, we have observed that essential proteins tend to be hub proteins in RNN topology. Additionally, essential genes are enriched in clusters containing many hub proteins in RNN topology (RNN protein clusters). Based on these two properties of essential genes in RNN topology, we have proposed a new measure; the RNN cluster centrality. Results from a variety of PPI networks demonstrate that RNN cluster centrality outperforms other centrality measures with regard to the proportion of selected proteins that are essential proteins. We also investigated the biological importance of RNN clusters. Conclusions This study reveals that RNN cluster centrality provides the best correlation of protein essentiality and placement of proteins in PPI network. Additionally, merged RNN clusters were found to be topologically important in that essential proteins are significantly enriched in RNN clusters, and biologically important because they play an important role in many Gene Ontology (GO) processes.http://deepblue.lib.umich.edu/bitstream/2027.42/78257/1/1471-2105-11-505.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78257/2/1471-2105-11-505-S1.DOChttp://deepblue.lib.umich.edu/bitstream/2027.42/78257/3/1471-2105-11-505.pdfPeer Reviewe

Due-date assignment and single machine scheduling with deteriorating jobs

Author name used in this publication: T. C. E. ChengAuthor name used in this publication: L. KangAuthor name used in this publication: C. T. Ng2003-2004 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Paired domination on interval and circular-arc graphs

Author name used in this publication: C. T. NgAuthor name used in this publication: L. Y. Kang2007-2008 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Single machine due-date scheduling of jobs with decreasing start-time dependent processing times

Published version at http://dx.doi.org/10.1111/j.1475-3995.2005.501_1.xAuthor name used in this publication: T. C. E. ChengAuthor name used in this publication: L. Y. KangAuthor name used in this publication: C. T. Ng2005-2006 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

An improved algorithm for the p-center problem on interval graphs with unit lengths

2006-2007 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Due-date assignment and parallel-machine scheduling with deteriorating jobs

Author name used in this publication: T. C. E. ChengAuthor name used in this publication: L. Y. KangAuthor name used in this publication: C. T. Ng2007-2008 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe