国内外关于医疗纠纷处置的利益相关者比较研究*

Objective: We learn about the methods, process, effects of each stakeholder and the principles of the disposition of medical dispute home and abroad through stakeholder analysis. Methods: We investigate the methods, process and the principles of the disposition of medical dispute home and abroad by literature retrieval, key informant interview and depth interview. Results: The stakeholders of medical disputes mainly include patients and families, medical staff and hospitals, pharmaceutical companies, governments, laws, non-government organizations and media. They play different roles in medical disputes and have different effects. Over all, patients and families, medical staff and hospitals have the greatest effect and then laws, media, government, non-government organizations and pharmaceutical companies. Conclusion: Different stakeholders affect the disposition of medical disputes differently. It is crucial to establish harmonious relationship between patients and doctors and to build harmonious society by untangling the responsibility between all the stakeholders and dispose medical disputes quickly and effectively.目的  通过利益相关者分析了解目前国内外医疗纠纷的处置办法、处理流程、各利益相关者的影响和责任推定原则。方法  通过文献检索、知情人访谈和深入访谈法，调查国内外目前医患纠纷处置的方法、流程和责任界定并进行比较。结果  医疗纠纷所涉及的利益相关者主要包括患者及家属、医疗人员和医院、医药公司、政府、法律、非政府组织和媒体，他们对医疗纠纷处置具有不同的立场和影响，其中患者及家属和医疗人员及医院的影响最大，其次为法律和媒体、政府、非政府组织、医药公司。结论  各个利益相关者对医疗纠纷处置的影响程度不同，合理评判各个利益相关者在医疗纠纷中的责任，快速、有效地解决医疗纠纷，是构建和谐医患关系和和谐社会的关键之一

Exclusive Charmonium Production at the Electron-ion collider in China

We investigate the exclusive $J/\psi$ production at the future Electron-ion collider in China by utilizing the eSTARlight event generator. We model the cross-section and kinematics by fitting to the world data of $J/\psi$ photoproduction. Projected statistical uncertainties on $J/\psi$ production are based on the design of a central detector, which consists of a tracker and vertex subsystem. The precision of the pseudo-data allows us to probe the near-threshold mechanism, e.g. the re-scattering effect. The significance of the forward amplitudes is discussed as well. The design and optimization of the detector enhance the potential for exploring the near-threshold region and the realm of high four-momentum transfer squared.Comment: 10 pages, 11 figure

Applications of Neural Organoids in Neurodevelopment and Regenerative Medicine

Recent advances in stem cell technologies have enabled the application of three-dimensional neural organoids for exploring the mechanisms of neurodevelopment and regenerative medicine. Over the past decade, series of studies have been carried out to investigate the cellular and molecular events of human neurogenesis using animal models, while the species differences between animal models and human being prevent a full understanding of human neurogenesis. Human neural organoids provide a new model system for gaining a more complete understanding of human neural development and their applications in regenerative medicine. In this chapter, the recent advances of the neural organoids of the brain and retina as well as their applications in neurodevelopment and regenerative medicine are reviewed

Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

Three observations have suggested that acid-sensing ion channels (ASICs) might be mammalian cutaneous mechanoreceptors; they are structurally related to Caenorhabditis elegans mechanoreceptors, they are localized in specialized cutaneous mechanosensory structures, and mechanical displacement generates an ASIC-dependent depolarization in some neurons. However, previous studies of mice bearing a single disrupted ASIC gene showed only subtle or no alterations in cutaneous mechanosensitivity. Because functional redundancy of ASIC subunits might explain limited phenotypic alterations, we hypothesized that disrupting multiple ASIC genes would markedly impair cutaneous mechanosensation. We found the opposite. In behavioral studies, mice with simultaneous disruptions of ASIC1a, -2 and -3 genes (triple-knockouts, TKOs) showed increased paw withdrawal frequencies when mechanically stimulated with von Frey filaments. Moreover, in single-fiber nerve recordings of cutaneous afferents, mechanical stimulation generated enhanced activity in A-mechanonociceptors of ASIC TKOs compared to wild-type mice. Responses of all other fiber types did not differ between the two genotypes. These data indicate that ASIC subunits influence cutaneous mechanosensitivity. However, it is unlikely that ASICs directly transduce mechanical stimuli. We speculate that physical and/or functional association of ASICs with other components of the mechanosensory transduction apparatus contributes to normal cutaneous mechanosensation

A High Precision and Multifunctional Electro‐Optical Conversion Efficiency Measurement System for Metamaterial‐Based Thermal Emitters

In this study, a multifunctional high-vacuum system was established to measure the electro-optical conversion efficiency of metamaterial-based thermal emitters with built-in heaters. The system is composed of an environmental control module, an electro-optical conversion measurement module, and a system control module. The system can provide air, argon, high vacuum, and other conventional testing environments, combined with humidity control. The test chamber and sample holder are carefully designed to minimize heat transfer through thermal conduction and convection. The optical power measurements are realized using the combination of a water-cooled KBr flange, an integrating sphere, and thermopile detectors. This structure is very stable and can detect light emission at the μW level. The system can synchronously detect the heating voltage, heating current, optical power, sample temperatures (both top and bottom), ambient pressure, humidity, and other environmental parameters. The comprehensive parameter detection capability enables the system to monitor subtle sample changes and perform failure mechanism analysis with the aid of offline material analysis using scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffraction. Furthermore, the system can be used for fatigue and high-low temperature impact tests

Effect of Bi-B-Si-Zn-Al glass additive on the properties of low-temperature sintered silicon carbide ceramics

In this study, the performance of low-temperature sintered Bi-B-Si-Zn-Al glass/SiC composites by vacuum hot-press sintering between 700°C and 1000°C was investigated. The specimen had a relatively preferable density of 95.5% and thermal conductivity of 8.660 Wm−1K−1 after sintering at 900°C for 2 h. The dielectric constant and dielectric loss tangle of the composite were 32.9 and 0.57 at 20 GHz, respectively. The XRD analysis indicated the formation of Bi, Zn and ZnAl2O4 crystals, and the microstructure showed the low contact angle of the glass and SiC grain. Such low-temperature sintered SiC ceramic may have a promising application in the electronic field

SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational pipeline to infer or unscramble the sequence of recombinations that created the observed genomes. Deep sequencing of 64 synIXR SCRaMbLE strains revealed 156 deletions, 89 inversions, 94 duplications, and 55 additional complex rearrangements; several duplications are consistent with a double rolling circle mechanism. Every SCRaMbLE strain was unique, validating the capability of SCRaMbLE to explore a diverse space of genomes. Rearrangements occurred exclusively at designed loxPsym sites, with no significant evidence for ectopic rearrangements or mutations involving synthetic regions, the 99% nonsynthetic nuclear genome, or the mitochondrial genome. Deletion frequencies identified genes required for viability or fast growth. Replacement of 3′ UTR by non-UTR sequence had surprisingly little effect on fitness. SCRaMbLE generates genome diversity in designated regions, reveals fitness constraints, and should scale to simultaneous evolution of multiple synthetic chromosomes.</jats:p