403 research outputs found
The effect of varying volume fraction of microcapsules on fresh, mechanical and self-healing properties of mortars
Spherical polymeric microcapsules, carrying liquid sodium silicate, were used for autonomic self-healing of mortars. Microcapsules were added at varying volume fractions (V), with respect to the cement volume, from as low as 4% up to 32% and their effect on fresh, mechanical and self-healing properties was investigated. For this purpose a series of techniques were used ranging from static mechanical testing, ultrasonic measurements, capillary sorption tests and optical microscopy. A detailed investigation was also carried out at the microstructural level utilising scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Results showed that although increasing V resulted in a ~27% reduction in the mechanical properties, the corresponding improvement in the self-healing potential was significantly higher. Areal crack mouth healing reached almost 100%. Also, the measured crack depth and sorptivity coefficient reduced to a maximum of 70% and 54% respectively in microcapsule-containing specimens. SEM/EDX observations showed that the regions in the periphery of fractured microcapsules are very dense. In this region, high healing product formation is also observed. Elemental analysis revealed that these products are mainly ettringite and calcium-silicate-hydrate (C-S-H).Engineering and Physical Sciences Research Council (Project Ref. EP/K026631/1 – ‘‘Materials for Life”)This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.conbuildmat.2016.06.11
Assessing the adaptation of arable farmers to climate change using DEA and bio-economic modelling
The objective of this article is to assess the impact of climate change on arable farming systems in Flevoland (the Netherlands) and to explore the adoption of different adaptation strategies. Data Envelopment Analysis (DEA) is applied that uses empirical data from individual farms to identify “best” current farm practices and derive relationships regarding current farm managemen
Polymeric microcapsules with switchable mechanical properties for self-healing concrete: synthesis, characterisation and proof of concept
Microcapsules, with sodium silicate solution as core, were produced using complex coacervation in a double, oil-in-water-in oil, emulsion system. The shell material was a gelatin–acacia gum crosslinked coacervate and the produced microcapsules had diameters ranging from 300 to 700 μm. The shell material designed with switchable mechanical properties. When it is hydrated exhibits soft and ‘rubbery’ behaviour and, when dried, transitions to a stiff and ‘glassy’ material. The microcapsules survived drying and rehydrating cycles and preserved their structural integrity when exposed to highly alkaline solutions that mimic the pH environment of concrete. Microscopy revealed that the shell thickness of the microcapsules varies across their perimeter from 5 to 20 μm. Thermal analysis showed that the produced microcapsules were very stable up to 190 °C. Proof of concept investigation has demonstrated that the microcapsules successfully survive and function when exposed to a cement-based matrix. Observations showed that the microcapsules survive mixing with cement and rupture successfully upon crack formation releasing the encapsulated sodium silicate solution.Financial support from the Engineering and Physical Sciences Research Council (EPSRC—United Kingdom) for this study (Project Ref. EP/K026631/1—‘Materials for Life’) is gratefully acknowledged
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First UK field application and performance of microcapsule-based self-healing concrete
Maintaining the health and reliability of our infrastructure is of strategic importance. The current state of the UK infrastructure, and the associated huge costs of inspection, maintenance, repair and eventual replacement, is not sustainable and is no longer environmentally viable. The design of infrastructure, mainly concrete, remains traditional and poor material performance continues to be the main cause of deterioration and failure in our infrastructure systems. Biomimetic materials, that emulate natural biological systems in their ability to self-healing, provide an exciting and plausible solution. Embedding cementitious materials with in-built capabilities to sense and respond to their environmental triggers could potentially eliminate all external interventions and deliver a resilience infrastructure. The work presented in this paper forms part of a national initiative that has been developing biomimetic cementitious infrastructure materials which culminated in the first large-scale field trials of self-healing concrete in the UK testing four different but complementary technologies that were developed. This paper focuses on one self-healing technology, namely microcapsules, which contain a healing agent that is released on their rupture as a result of crack propagation. The paper will present details of the microcapsules used, their implementation in concrete and in the field trials and time-related, field and laboratory, assessment of the self-healing process. It also highlights challenges faced and improvements that are now on-going to produce the next generation of the microcapsule self-healing cementitious system
Climate change adaptation in agriculture; the use of multi-scale modelling and stakeholder participation in the Netherlands
Abstract about a research project to develop a methodology to assess adaptation of agriculture to climatic and socio-economic changes at multiple scales, with a first application in the Province of Flevoland, the Netherlands
Side-Chain Modified [<sup>99m</sup>Tc]Tc-DT1 Mimics:A Comparative Study in NTS<sub>1</sub>R-Positive Models
Radiolabeled neurotensin analogs have been developed as candidates for theranostic use against neurotensin subtype 1 receptor (NTS1R)-expressing cancer. However, their fast degradation by two major peptidases, neprilysin (NEP) and angiotensin-converting enzyme (ACE), has hitherto limited clinical success. We have recently shown that palmitoylation at the ε-amine of Lys7 in [99mTc]Tc-[Lys7]DT1 (DT1, N4-Gly-Arg-Arg-Pro-Tyr-Ile-Leu-OH, N4 = 6-(carboxy)-1,4,8,11-tetraazaundecane) led to the fully stabilized [99mTc]Tc-DT9 analog, displaying high uptake in human pancreatic cancer AsPC-1 xenografts but unfavorable pharmacokinetics in mice. Aiming to improve the in vivo stability of [99mTc]Tc-DT1 without compromising pharmacokinetics, we now introduce three new [99mTc]Tc-DT1 mimics, carrying different pendant groups at the ε-amine of Lys7: MPBA (4-(4-methylphenyl)butyric acid)—[99mTc]Tc-DT10; MPBA via a PEG4-linker—[99mTc]Tc-DT11; or a hydrophilic PEG6 chain—[99mTc]Tc-DT12. The impact of these modifications on receptor affinity and internalization was studied in NTS1R-positive cells. The effects on stability and AsPC-1 tumor uptake were assessed in mice without or during NEP/ACE inhibition. Unlike [99mTc]Tc-DT10, the longer-chain modified [99mTc]Tc-DT11 and [99mTc]Tc-DT12 were significantly stabilized in vivo, resulting in markedly improved tumor uptake compared to [99mTc]Tc-DT1. [99mTc]Tc-DT11 was found to achieve the highest AsPC-1 tumor values and good pharmacokinetics, either without or during NEP inhibition, qualifying for further validation in patients with NTS1R-positive tumors using SPECT/CT.</p
Key-protease inhibition regimens promote tumor targeting of neurotensin radioligands
Neurotensin subtype 1 receptors (NTS1R) represent attractive molecular targets for directing radiolabeled neurotensin (NT) analogs to tumor lesions for diagnostic and therapeutic purposes. This approach has been largely undermined by the rapid in vivo degradation of linear NT-based radioligands. Herein, we aim to increase the tumor targeting of three99mTc-labeled NT analogs by the in-situ inhibition of two key proteases involved in their catabolism. DT1 ([N4- Gly7]NT(7-13)), DT5 ([N4-βAla7,Dab9]NT(7-13)), and DT6 ([N4-βAla7,Dab9,Tle12]]NT(7-13)) were labeled with99mTc. Their profiles were investigated in NTS1R-positive colon adenocarcinoma WiDr cells and mice treated or not with the neprilysin (NEP)-inhibitor phosphoramidon (PA) and/or the angiotensin converting enzyme (ACE)-inhibitor lisinopril (Lis). Structural modifications led to the partial stabilization of99mTc-DT6 in peripheral mice blood (55.1 ± 3.9% intact), whereas99mTc-D
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Exploring adaptation strategies for climate change in the Netherlands: a bio-economic farm level analysis
PowerPoint presentation given at the European meeting of the international Microsimulation Association, Dublin, 17-19 May 2012
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