The Role of Early Intervention Programs on Reducing the Negative Effects of Poverty

Children under the age of 18 are the largest age group of people who live in poverty in America. This paper focuses on early intervention programs and how they can help ameliorate the negative effects of poverty. Previous research has demonstrated the negative effects of poverty, such as lower academic performance and achievement and more behavioral problems. Various risk factors for poverty, such as single parents, low maternal education, and lack of resources, and their role in the design of early intervention programs will be explained. The Perry Preschool Project (PPP), Head Start, the Chicago Child-Parent Center (CPC) Program, and the Carolina Abecedarian Project and their effects on child outcomes will be analyzed. Cost-benefit analyses for each early intervention program, as well as future considerations for public policy, will be discussed in this paper

Gamma Radiation and Cold Treatments for the Disinfestation of the Mediterranean Fruit Fly in California-Grown Oranges and Lemons

Low-dose gamma radiation and cold treatments were tested for their effectiveness in the disinfestation of the Mediterranean fruit fly, Ceratitis capitata, from California-grown navel oranges and Calfame lemons. Cold treatments were applied for 7, 14, or 21 days to simulate postharvest storage and/or shipment durations and temperatures (5.5°C for oranges and 11.1°C for lemons). Low-dose gamma radiation treatments were applied at various dosages, both independent of and in tandem with cold treatments. The results of egg hatchability and larval survival studies show that a synergistic effect is observed when gamma radiation and cold treatments are used in tandem. The data show that infested navel oranges stored for 14-21 days at 5.5°C required a radiation dose of 0.30 kGy or less to result in very low, or no, hatch of mature medfly eggs. Furthermore, identical treatment of mature medfly larvae resulted in no adult eclosion from pupae. Shorter durations of cold storage, however, require considerably higher dosages to observe similar mortality rates and may not be desirable as fruit quality may be affected at these higher do sages . Calfame lemons require higher dosages than oranges to ob serve similar mortality rates at the same cold treatment durations due to the higher temperature 11.1°C) at which they are stored. The data show that irradiation at 0.30 kGy with cold storage of 21 days or irradiation at 0.50 kGy with cold storage of 14 days is sufficient to cause nearly total egg mortality

Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography

Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT). More recently, the radioiodinated (R,S)-stereoisomer of 123I-INER, 123I-NKJ64, has been synthesized and preliminary evaluation in rats has been reported. This article reports the brain distribution and pharmacokinetic properties of 123I-NKJ64 in baboons and compares results with 123I-INER data in the same species. SPECT studies were conducted in two ovariectomized adult female baboons using two different protocols: (1) bolus of 123I-INER or 123I-NKJ64; and (2) bolus plus constant infusion of 123I-NKJ64 with reboxetine (2.0 mg/kg) administration at equilibrium. Following bolus injection, both radiotracers rapidly and avidly entered the baboon brain. The regional brain accumulation of 123I-NKJ64 did not match the known distribution of NAT in baboon brain, contrasting with previous results obtained in rats. Conversely, the regional distribution of 123I-INER was consistent with known distribution of NAT in baboon brain. No displacement of 123I-NKJ64 was observed following administration of reboxetine. This contrasts with previous data obtained for 123I-INER, where 60% of specific binding was displaced by a lower dose of reboxetine. These data suggest that 123I-NKJ64 may lack affinity and selectivity for NAT in baboon brain and 123I-INER is the most promising iodinated reboxetine analogue developed to date for in vivo imaging of NAT in brain using SPECT. This study highlights the importance of species differences during radiotracer development and the stereochemical configuration of analogues of reboxetine in vivo. Synapse, 2012. -® 2012 Wiley Periodicals, In

Hydrophobic interactions at subsite S1′ of human dipeptidyl peptidase IV contribute significantly to the inhibitory effect of tripeptides

Functional inhibitory peptides of human dipeptidyl peptidase 4 (hDPP4) have been highly anticipated as the active ingredient of functional food for type II diabetes; however, the molecular mechanism of hDPP4 inhibition remains unclear. In this study, we focused on dipeptides and tripeptides, which display structure-function correlations that are relatively easy to analyze, and examined their interactions with hDPP4 on an atomic level using a combination of docking studies and an hDPP4 inhibition assay. First, we performed comprehensive binding mode analysis of the dipeptide library and demonstrated that the formation of a tight interaction with the S1 subsite composing part of the substrate pocket is essential for dipeptides to compete with the substrate and strongly inhibit hDPP4. Next, we synthesized tripeptides by adding various amino acids to the C-terminus of Ile-Pro and Val-Pro, which have especially high inhibitory activity among compounds in the dipeptide library, and measured the hDPP4 inhibitory activity of the tripeptides. When hydrophobic amino acids (Ile, Met, Val, Trp) were added, the inhibitory activity increased several-fold. This phenomenon could be explained as follows: the C-terminal amino acid of the tripeptide formed hydrophobic interactions with Tyr547 and Trp629, which compose the S1′ subsite located relatively outside the substrate pocket, thereby stabilizing the hDPP4-peptide binding. The structural information on the interaction between hDPP4 and peptide inhibitors attained in this study is anticipated to be useful in the development of a more potent hDPP4 competitive inhibitor

Hepatobiliary and pancreatic imaging in children—techniques and an overview of non-neoplastic disease entities

Imaging plays a major role in the diagnostic work-up of children with hepatobiliary or pancreatic diseases. It consists mainly of US, CT and MRI, with US and MRI being the preferred imaging modalities because of the lack of ionizing radiation. In this review the technique of US, CT and MRI in children will be addressed, followed by a comprehensive overview of the imaging characteristics of several hepatobiliary and pancreatic disease entities most common in the paediatric age group