The Impact of Self-reported Visual Disability on Quality of Life among Older Persons in a Rural Area of Northeast Thailand: A Follow-up Study

A population-based cross-sectional study was conducted to follow-up an earlier study which estimated the prevalence of self-reported visual disability and its impact on the quality of life (QOL) of older persons living in a rural area of Northeast Thailand based on a secondary analysis of data collected for another purpose. Self-reported difficulty with seeing was used to determine prevalence of visual disability. The WHOQOL-BREF and WHOQOL-OLD were used to assess the impact of visual disability on QOL. Fifty nine percent reported having difficulty seeing to the extent that it interfered with their daily life. Those who reported having difficulty with seeing were found to be older, disproportionately female, have lower perception of health, and to score lower on QOL than those who did not. The findings of this study differed from the earlier study. It is asserted that the findings from this latter study are likely to be more representative of the situation due to the use of a more systematic and targeted sampling procedure

The Impact of Self-reported Visual Disability on Quality of Life among Older Persons in a Rural Area of Northeast Thailand: A Follow-up Study

A population-based cross-sectional study was conducted to follow-up an earlier study which estimated the prevalence of self-reported visual disability and its impact on the quality of life (QOL) of older persons living in a rural area of Northeast Thailand based on a secondary analysis of data collected for another purpose. Self-reported difficulty with seeing was used to determine prevalence of visual disability. The WHOQOL-BREF and WHOQOL-OLD were used to assess the impact of visual disability on QOL. Fifty nine percent reported having difficulty seeing to the extent that it interfered with their daily life. Those who reported having difficulty with seeing were found to be older, disproportionately female, have lower perception of health, and to score lower on QOL than those who did not. The findings of this study differed from the earlier study. It is asserted that the findings from this latter study are likely to be more representative of the situation due to the use of a more systematic and targeted sampling procedure

Retinal Image Registration and Comparison for Clinical Decision Support

Background For eye diseases, such as glaucoma and age-related macular degeneration (ARMD), involved in long-term degeneration procedure, longitudinal comparison of retinal images is a common step for reliable diagnosis of these kinds of diseases. Aims To provide a retinal image registration approach for longitudinal retinal image alignment and comparison. Method Two image registration solutions were proposed for facing different image qualities of retinal images to make the registration methods more robust and feasible in a clinical application system. Results Thirty pairs of longitudinal retinal images were used for the registration test. The experiments showed both solutions provided good performance for the accurate image registrations with efficiency. Conclusion We proposed a set of retinal image registration solutions for longitudinal retinal image observation and comparison targeting a clinical application environment

Evaluation of cholinergic deficiency in preclinical Alzheimer\u27s disease using pupillometry

Cortical cholinergic deficiency is prominent in Alzheimer’s disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N=14) and cognitively normal healthy control (HC, N=115) participants, with the HC group stratified according to high (N=38) and low (N=77) neocortical amyloid burden (NAB). Constriction phase PFR parameters were significantly reduced in AD compared to HC (maximum acceleration p \u3c 0.05, maximum velocity p \u3c 0.0005, average velocity p \u3c 0.005, and constriction amplitude p \u3c 0.00005). The high-NAB HC subgroup had reduced PFR response cross-sectionally, and also a greater decline longitudinally, compared to the low-NAB subgroup, suggesting changes to pupil response in preclinical AD. The results suggest that PFR changes may occur in the preclinical phase of AD. Hence, pupillometry has a potential as an adjunct for noninvasive, cost-effective screening for preclinical AD

Ocular biomarkers for early detection of Alzheimer\u27s Disease

Alzheimer\u27s disease (AD) is the most common form of dementia and is clinically characterized by a progressive decline in memory, learning, and executive functions, and neuropathologically characterized by the presence of cerebral amyloid deposits. Despite a century of research, there is still no cure or conclusive premortem diagnosis for the disease. A number of symptom-modifying drugs for AD have been developed, but their efficacy is minimal and short-lived. AD cognitive symptoms arise only after significant, irreversible neural deterioration has occurred; hence there is an urgent need to detect AD early, before the onset of cognitive symptoms. An accurate, early diagnostic test for AD would enable current and future treatments to be more effective, as well as contribute to the development of new treatments. While most AD related pathology occurs in the brain, the disease has also been reported to affect the eye, which is more accessible for imaging than the brain. AD-related proteins exist in the normal human eye and may produce ocular pathology in AD. There is some homology between the retinal and cerebral vasculatures and the retina also contains nerve cells and fibers that form a sensory extension of the brain. The eye is the only place in the body where vasculature or neural tissue is available for non-invasive optical imaging. This article presents a review of current literature on ocular morphology in AD and discusses the potential for an ocular-based screening test for AD

MEDLINE versus EMBASE and CINAHL for telemedicine searches

Introduction: Researchers in the domain of telemedicine throughout the world tend to search multiple bibliographic databases to retrieve the highest possible number of publications when conducting review projects. Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica Database (EMBASE), and Cumulative Index to Nursing and Allied Health Literature (CINAHL) are three popular databases in the discipline of biomedicine that are used for conducting reviews. Access to the MEDLINE database is free and easy, whereas EMBASE and CINAHL are not free and sometimes not easy to access for researchers in small research centers. Objective: This project sought to compare MEDLINE with EMBASE and CINAHL to estimate what proportion of potentially relevant publications would be missed when only MEDLINE is used in a review project, in comparison to when EMBASE and CINAHL are also used. Methods: Twelve simple keywords relevant to 12 different telemedicine applications were searched using all three databases, and the results were compared. Results: About 9%-18% of potentially relevant articles would have been missed if MEDLINE had been the only database used. Conclusions: It is preferable if all three or more databases are used when conducting a review in telemedicine. Researchers from developing countries or small research institutions could rely on only MEDLINE, but they would loose 9%-18% of the potentially relevant publications. Searching MEDLINE alone is not ideal, but in a resource-constrained situation, it is definitely better than nothing